Murugappan Ramanathan, Jr. M.D.

Assistant Professor, Otolaryngology-Head and Neck Surgery, Johns Hopkins Sinus Center

PHONE
443-287-2000 or 301-896-3330

EDUCATION - Undergraduate
Yale University

EDUCATION – Medical School
University of Texas Medical Branch at Galveston

EDUCATION – Residency
The Johns Hopkins Hospital

EDUCATION – Fellowship
The Johns Hopkins Hospital (Rhinology and Sinus Surgery)

PRACTICE LOCATION
Johns Hopkins Otolaryngology Head and Neck Specialty Services in the Greater Washington Region - Bethesda

CLINICAL INTERESTS

• Complex and Revision Endoscopic Sinus Surgery
• Management of Nasal Polyps
• Endoscopic repair of Cerebrospinal Fluid leaks
• Endoscopic approaches to Sinonasal and Anterior Skull Base Tumors

RESEARCH INTERESTS

• Molecular and immunologic (innate and adaptive) mechanisms underlying the pathogenesis of chronic rhinosinusitis with nasal polyps.
• Role of Allergy and Environmental pollutants in propagating sinonasal inflammation

BOARD CERTIFICATION
American Board of Otolaryngology

PRINCIPAL HOSPITAL
Suburban Hospital
The Johns Hopkins Hospital

PUBLICATIONS
Murugappan Ramanathan, Jr., Won-Kyung Lee, and Andrew P. Lane. Increased Expression of Acidic Mammalian Chitinase (AMCase) is Associated With Chronic Rhinosinusitis with Nasal Polyps. Am J. Rhinol. 2006 May-Jun; 20(3):330-335

Murugappan Ramanathan, Jr., Ernst W. Spannhake, and Andrew P. Lane. Decreased Expression of Interleukin 22 Receptor is Associated With Chronic Rhinosinusitis with Nasal Polyps.  Laryngoscope 2007 Oct; 117(10):1839-43

Murugappan Ramanathan, Jr. and Andrew P. Lane. A Comparison of Experimental Methods in Molecular Chronic Rhinosinusitis Research. Am J. Rhinol. 2007 May-Jun; 21(3): 373-7

Murugappan Ramanathan, Jr., Won K. Lee, Marc G. Dubin, Sandra Lin, Ernst W. Spannhake, and Andrew P. Lane. Sinonasal Epithelial Cell Expression of Toll-Like Receptor 9 is Decreased in Chronic Rhinosinusitis with Nasal Polyps. Am. J. Rhinol 2007 Jan-Feb; 21(1): 110-116

Murugappan Ramanathan, Jr. and Andrew P. Lane. Innate Immunity of the Sinonasal Cavity and its Role in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2007 Mar; 136(3):348-56. Review.

Won K. Lee, Murugappan Ramanathan, Jr., Ernst. W. Spannhake, and Andrew P. Lane. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and HBD-2 by sinonasal epithelial cells.  Am. J. Rhinol. 2007 Nov-Dec; 21 (6) 658-663

Murugappan Ramanathan, Jr., Won K. Lee, Ernst W. Spannhake, and Andrew P. Lane. Th2 Cytokines Associated with Chronic Rhinosinusitis with Polyps Down-Regulate the Anti-Microbial Immune Function of Human Sinonasal Epithelial Cells. Am. J. Rhinol. 2008 Mar-Apr; 22(2) 115-21

Ashley Lalaker, Louis Nkrumah, Won K. Lee, Murugappan Ramanathan, Jr., and Andrew P. Lane. Dust Mite Antigen Modulates Innate Immune Gene Expression By Human Sinonasal Epithelial Cells. Am. J. Rhinol Allergy 2009 Jan-Feb; 23(1)8-14

Douglas Reh, Yadong Wang, Leda Pawliuk, Murugappan Ramanathan, Jr., and Andrew P. Lane. Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J. Rhinol Allergy 2010 Mar;24(2):105-9.

Murugappan Ramanathan, Jr., Justin Turner, and Andrew P. Lane. Technological Advances in Rhinologic Basic Science Research. Otolaryngology Clinics 2009. Oct; 42(5):867-81