The Department of Otolaryngology-Head & Neck Surgery

Charley C. Della Santina, MD, PhD
Associate Professor,
Department of Otolaryngology - Head & Neck Surgery,
Division of Otology, Neurotology & Skullbase Surgery,
Department of Biomedical Engineering

Peer-Reviewed Journal Articles

Della Santina CC, Migliaccio AA, Patel AH (2007) “A multi-channel semicircular canal neural prosthesis using electrical stimulation to restore 3D vestibular sensation,” IEEE Transaction on Biomed. Engineering 2007 Jun;54(6 Pt 1):1016-30.

Schubert MC, Migliaccio AA, Della Santina CC (2007) “Modification of compensatory saccades after aVOR gain recovery,” J Vestib Res. 2006;16(6):285-91.

Lyford-Pike S, Vogelheim C, Chu E, Della Santina CC, Carey JP (2007) "Differential uptake explains the selective toxicity of gentamicin for vestibular type I hair cells," JARO 2007 Sep 25; [Epub ahead of print]

Schubert MS, Migliaccio AA, Della Santina CC (2006) “Dynamic visual acuity in canal planes as a test of isolated semicircular canal dysfunction,” JARO 2006 Dec;7(4):329-38

Della Santina CC and Lee SC (2006) “Ceravital reconstruction after canal wall down mastoidectomy – Long term results,” Archives of Otolaryngology – Head & Neck Surgery 2006 Jun;132(6):617-23.

Della Santina CC, Byrne PJ (2006) “Initial management of total nasal septectomy defects using resorbable plating,” Arch Facial Plast Surg. 2006 Mar-Apr; 8(2):128-38. PMID: 16549740

Migliaccio AA, Della Santina CC, Carey JP, Minor LB, Zee DS (2006) “The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflex.” Vision Res. 2006 Mar 16; [Epub ahead of print] PMID: 16545855

Migliaccio AA, Schubert MC, Clendaniel RA, Carey JP, Della Santina CC, Minor LB, Zee DS (2006) “Axis of eye rotation changes with head-pitch orientation during head impulses about Earth-vertical,” JARO. 2006 Mar 22; [Epub ahead of print] PMID: 16552499

Hourany, R. Aygun N, Della Santina CC, Zinreich S.J. (2005) “Silent sinus syndrome: An acquired condition,” AJNR Am J Neuroradiol October 26:2390-2392.

Della Santina CC, Potyagaylo V, Migliaccio AA, Minor LB, Carey JP (2005) “Orientation of human semicircular canals measured by three-dimensional multi-planar CT reconstruction,” JARO 2005 Aug 9:1-16 [Epub ahead of print]

Della Santina CC, Migliaccio AA, Patel AH (2005) “Electrical Stimulation to Restore Vestibular Function – Development of a 3-D Vestibular Prosthesis,” Conf Proc IEEE Eng Med Biol Soc. 2005;7:7380-5

Migliaccio AA, Della Santina CC, Carey JP, H.W. Francis, L. R. Lustig, J.K. Niparko, Minor LB (2005) “The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantation,” Otology & Neurotology. 2005 Jul;26(4):655-60.

Park HJ, Migliaccio AA, Della Santina CC, Minor LB, Carey JP (2005) “Search-coil head-thrust and caloric tests in Meniere’s disease,” Acta Otolaryngol. 2005 Aug;125(8):852-7.

Potyagaylo V, Della Santina CC and Carey JP (2005) “Superior canal dehiscence is not due to cephalic displacement of the labyrinth,” Annals NY Acad. Sci. 2005 Apr;1039:498-502

Hullar TE, Della Santina CC, Hirvonen TP, Lasker DM, Carey JP, Minor LB (2004) “Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotations. J Neurophysiol. 2005 May;93(5):2777-86. Epub 2004 Dec 15.

Migliaccio AA, MacDougall HG, Minor LB , Della Santina CC, (2004) “Inexpensive system for real-time 3-dimensional video-oculography using a fluorescent marker array,” J. Neuroscience Methods 2005 Apr 30;143(2):141-50. Epub 2004 Nov 28

Rubinstein J and C. C. Della Santina, “Development of a biophysical model for vestibular prosthesis research,” Journal of Vestibular Research 2002-2003;12(2-3):69-76.

Della Santina CC, Cremer PD, J.P.Carey, and Minor LB (2002) “Comparison of head thrust test and head autorotation test reveals vestibulo-ocular reflex is enhanced during voluntary head movements” Archives of Otolaryngology – Head & Neck Surgery 128(9):1044-1054.

Carey JP, Minor LB, Peng GCY, Della Santina CC, Cremer PD and Haslwanter T (2002) “Changes in the three-dimensional vestibulo-ocular reflex following intratympanic gentamicin treatment for Meniere’s disease,” Journal of the Assoc. of Research in Otolaryngology 3(4):430-443

Carey JP, Hirvonen T, Peng GCY, Della Santina CC, Cremer PD, Haslwanter T, Minor LB (2002) “Changes in angular VOR after a single dose of intratympanic gentamicin for Meniere’s disease,” Ann. New York Acad. Sci 2002 Apr; 956:581-4

Della Santina CC, Cremer PD, Carey JP and Minor LB (2001) “The vestibulo-ocular reflex during self-generated head movements by human subjects with unilateral vestibular hypofunction: improved gain, latency and alignment provide evidence for preprogramming,” Ann. New York Acad. Sci 942: 456-466.

Minor LB, Cremer PD, Carey JP, Della Santina CC, Streubel SO and Weg N (2001) “Symptoms and signs in superior canal dehiscence syndrome,” Ann. New York Acad. Sci 942:259-273.

Cremer PD, Minor LB, Carey JP, Della Santina CC (2000) “Eye movements in patients with the superior semicircular canal dehiscence syndrome align with the abnormal canal,” Neurology 55(12):1833-1841.

Della Santina CC, Kovacs GTA, Lewis ER (1997) “Chronic multicellular recording from eighth cranial nerve using micromachined silicon electrode arrays,” J Neurosci Methods 72:71-86.

Della Santina CC (1994) “Silicon Regeneration-Type Multi-Microelectrodes for Electrophysiology in the Eighth Cranial Nerve,” Doctoral Dissertation, Bioengineering, UC Berkeley/UC San Francisco.

Kovacs GTA, Storment C, Halks-Miller M, Belczynski C, Della Santina CC, Lewis ER, Maluf N (1994) “Silicon-substrate microelectrode arrays for parallel recording of neural activity in peripheral and cranial nerves,” IEEE Transactions on Biomedical Engineering 41(6):567-577.

Conference Abstracts & Presentations

Migliaccio AA, Meierhoffer R, Della Santina CC, Reeves R, "3D Angular vestibulo-ocular reflex of C57BL6 and Ts65Dn mice," Abstr 791, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Schubert M, Shelhamer M and Della Santina CC, "VOR adaptation to active head impulses," Abstr 793, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Tang S, Melvin TN, Della Santina CC, "Effects of vestibular implantation on hearing in chinchillas," Abstr 78, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Hayden RP, Mori S, Della Santina CC, "An electroanatomical/neuromorphic model to guide electrode design for a multichannel vestibular prosthesis," Abstr 792, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Melvin TN, Migliaccio AA, Della Santina CC, "Effects of cochlear implantation on vestibular function," Abstr 244, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Migliaccio AA, Della Santina CC, Carey JP, “Vergence-mediated modulation of the human vestibulo-ocular reflex during galvanic stimulation,” Abstr 795, Assoc for Research in Otolaryngology Ann Mtg, Phoenix 2008

Della Santina CC, Hayden R, Migliaccio AA, Melvin T, "Restoring semicircular canal sensation using the Johns Hopkins Multichannel Vestibular Prosthesis," Proc Biomed. Engineering Soc Ann Mtg, Sept 2007

Xiang Y, Yakushin SB, Kunin M, Raphan T, Minor LB, Della Santina CC, Cohen B, “Changes in quadrupedal locomotion and head stabilization in space after canal-plugging in monkey,” Soc for Neurosci. Ann. Mtg, San Diego 2007

Soledad Boleas M, Della Santina CC, Minor LB, Carey LP, "Longitudinal results with intratympanic dexamethasone in the treatment of Meniere’s disease," American Neurotol. Soc Ann. Mtg, San Diego, 2007

Hayden RP, Mori S, Frey E, Della Santina CC, "An anatomically precise finite element model predicts current flow in labyrinths implanted with a multi-channel vestibular prosthesis," Abstract #941, Assoc for Research in Otolaryngology Ann Mtg, Denver 2007

Hayden RP and Della Santina CC, "Paired linear accelerometers emulate gyros to reduce power consumption and size for an implantable multi-channel vestibular prosthesis," Abstract #942, Assoc for Research in Otolaryngology Ann Mtg, Denver 2007

Migliaccio AA and Della Santina CC, "Videooculography system for 3D angular eye position measurement in the mouse," Abstract #943, Assoc for Research in Otolaryngology Ann Mtg, Denver 2007

Migliaccio AA, Minor LB and Della Santina CC, "The 3-Dimensional angular vestibulo-ocular reflex evoked by high-acceleration rotations in normal chinchilla is conjugate, nonlinear and isotropic," Abstract #944, Assoc for Research in Otolaryngology Ann Mtg, Denver 2007

Schubert M, Shelhamer M and Della Santina CC, "Incremental adjustment of velocity error signal enhances VOR adaptation," Abstract #974, Assoc for Research in Otolaryngology Ann Mtg, Denver 2007

Campbell CA, Della Santina CC, Smith NB, Carey JP, Minor LB, Smith RJH (2006) "Is Ménière’s disease associated with polymorphisms in KCNE1 or KCNE3 in the United States?" American Society of Human Genetics Ann. Mtg., New Orleans Oct 2005

Della Santina CC, Migliaccio AA, Patel AH, Carey JP, Park HJ, Anderson ICW, Minor L (2006) “A Multichannel Implantable Prosthesis for Restoration of 3D Vestibular Function,” Abstract 9, Assoc for Research in Otolaryngology Ann Mtg 2006

Allak A, Della Santina CC, Schubert MC (2005) “Dynamic visual acuity in canal planes as a test of isolated semicircular canal dysfunction,” Society for Neuroscience Annual Mtg, Washington DC Nov 2005

Della Santina CC, Migliaccio AA, Patel AH (2005) “A Multichannel Implantable Prosthesis for Restoration of 3D Vestibular Function,” Proceedings of the Biomedical Engineering Society Annual Fall Mtg, Sept 29, 2005

Della Santina CC, Migliaccio AA, Park HJ, Anderson IW, Jiradejvong P, Minor LB and Carey JP, “3D Vestibuloocular reflex, afferent responses and crista histology in chinchillas after unilateral intratympanic gentamicin,” Abstract 813, Assoc for Research in Otolaryngology Ann Mtg 2005

Stewart CM, Della Santina CC, Migliaccio AA, Minor LB, Carey JP, “Intratympanic gentamicin in human subjects: A lesion intermediate between canal plugging and surgical destruction,” Abstract 1391, Assoc for Research in Otolaryngology Ann Mtg 2005

Migliaccio AA, Schubert M, Carey JP, Della Santina CC, Minor LB, Clendaniel R, “The axis of eye rotation during the vestibuloocular reflex can obey a half angle rule,” Abstract 736, Assoc for Research in Otolaryngology Ann Mtg 2005

Della Santina CC, Migliaccio AA, Park HJ, Jiradejvong P, Minor LB and Carey JP, “Vestibulo-ocular reflex of chinchilla after unilateral intratympanic gentamicin,” Abstract 411.6, Society for Neuroscience Ann Mtg 2004

Campbell CA, Della Santina CC, Avenarius MR, Carey JP, Minor LB, Smith NB, Van Camp G, Smith RJH, “Genetic analysis of Meniere’s disease,” 5th Molecular Biology of Hearing and Deafness 2004

Della Santina CC, Migliaccio AA and Minor LB, “Vestibulo-ocular reflex of chinchilla during head rotation and functional vestibular electrical stimulation,” Barany Society 2004 Congress, Paris

Della Santina CC, Potyagaylo V Migliaccio AA, Minor LB and Carey JP, “Orientation of human vestibular labyrinth semicircular canals,” Clinical and Basic Oculomotor Research (Satellite Mtg of the Barany 2004 Congress), Siena, July 2004

Migliaccio AA, Della Santina CC, Carey JP and Zee DS, “The human angular torsional vestibulo-ocular reflex: effects of eye position and head rotation plane.” Barany Society 2004 Congress, Paris

Della Santina CC, Potyagaylo V Migliaccio AA, Minor LB and Carey JP, “Orientations of human vestibular labyrinth semicircular canals,” Abstract 272, Assoc. for Research in Otolaryng. Ann Mtg 2004

Potyagaylo V, Della Santina CC, Minor LB and Carey JP “Superior canal dehiscence is not due to cephalic displacement of the labyrinth,” Assoc. for Research in Otolaryng. Ann Mtg 2004

Della Santina CC, Migliaccio AA, Carey JP and Minor LB, “Vestibulo-ocular reflex of chinchilla during high frequency head rotation and electrical stimuli,” Abst 13759, Soc for Neurosci Ann Mtg 2003

Della Santina CC, Migliaccio AA and Minor LB, “Vestibulo-ocular reflex of chinchilla during head rotation and functional vestibular electrical stimulation,” NIH Neural Prosthesis Program Workshop 2003

Rubinstein JT & Della Santina CC, “Development of a biophysical model for a vestibular prosthesis,” Biomedical Engineering Society2003 Annual Meeting, Nashville

Della Santina CC, Hullar TE, Carey JP, Migliaccio AA and Minor LB, “Comparison of vestibular nerve afferent and eye movement responses to galvanic and rotational stimuli,” American Otological Society Annual Meeting 2003, Nashville

Migliaccio AA, Della Santina CC, Carey JP, Francis HW, Lustig LR, Niparko JK, Minor LB, “Function of the vestibulo-ocular reflex before and after cochlear implantation,” Cochlear Implants in Children 2003, Washington DC.

Della Santina CC, Lewis ER, “The spatial distribution of nodes of Ranvier and ‘units’ recorded using microelectrodes in the eighth nerve,” Assoc for Research in Otolaryng. 2002 Annual Mtg, St. Pete’s Beach

Della Santina CC, Cremer PD, Carey JP, Minor LB , “Increased gain, shortened latency and improved 3D alignment – evidence for preprogramming of the vestibular ocular reflex during self-generated head movements by human subjects with unilateral vestibular hypofunction,” Washington University Vestibular Function Conf. 2000, St. Louis

Carey JP, Haslwanter TP, Della Santina CC, Peng CGY, Minor LB, “Preservation of semicircular canal function in gentamicin treatment of Meniere’s disease,” Society for Neuroscience 2000 Annual Meeting, Washington DC

Cremer PD, Minor LB, Carey JP, Della Santina CC, “Vibration-induced nystagmus in superior canal dehiscence syndrome,” Society for Neuroscience 2000 Annual Meeting, Washington DC

Della Santina CC, Cremer PD, Carey JP, Minor LB, “Preprogramming augments the VOR during voluntary head movements - Implications for choosing a test of vestibular function,” Maryland Soc. of Otolaryngology – Head & Neck Surgery 2000 Annual Research Meeting, Baltimore

Della Santina CC, P. D. Cremer, Carey JP, Minor LB “Shortened latency and improved alignment imply preprogrammed mechanisms contribute to VOR during active head rotation after unilateral labyrinthectomy,” Assoc for Research in Otolaryngology 2000 Annual Meeting, St. Pete’s Beach

Carey JP, T. Haslwanter, Della Santina CC, Minor LB “3D VOR shows preserved canal function after intratympanic gentamicin for Meniere's Disease,” Assoc for Research in Otolaryngology 2000 Annual Meeting, St. Pete’s Beach

Cremer PD, Carey JP, Della Santina CC, Minor LB, “Superior canal dehiscence syndrome: characteristics of sound- and pressure-induced nystagmus,” ARO 2000 Annual Meeting, St. Pete’s Beach

Della Santina CC, Carey JP, P. D. Cremer, Minor LB “Comparison of passive head impulses and sinusoidal vestibular autorotation as measures of human vestibulo-ocular reflex function,” Society for Neuroscience 1999 Annual Meeting, Miami Beach

Cremer PD, Carey JP, Della Santina CC, Minor LB, “Three dimensional examination of sound- and pressure-induced nystagmus in patients with superior semicircular canal dehiscence syndrome: axis of nystagmus is parallel to the anatomic axis of the affected canal,” Society for Neuroscience 1999 Annual Meeting, Miami Beach

Della Santina CC, Kovacs GTA, Lewis ER, “Modeling and measuring the distribution of nodes of Ranvier and units in bullfrog eighth nerve aids in microelectrode design,” Society for Neuroscience 1995 Annual Meeting 21(1):398, San Diego CA

Della Santina CC, Storment CW, Lewis ER and Kovacs GTA, “Chronic multicellular recording from eighth cranial nerve using silicon regeneration microelectrodes,” Society for Neuroscience 1993 Annual Meeting 19(1):887, Washington, DC

Della Santina CC, Lewis ER and Kovacs GTA, “Neural interfaces for auditory physiology research,” NIH Neural Prostheses 1992 Workshop, Bethesda

Hatzakis M, Della Santina CC, Maluf N and Kovacs GTA “Automated system for evaluation of stimulation and recording electrodes,” NIH Neural Prostheses 1992 Workshop, Bethesda

Grattarola M, Kovacs GTA, Martinoia S, Belczynski C, Cambiaso A, Storment C, Tedesco M and Della Santina CC, "In Vitro Networks of Neurons: Technological and Cytometric Aspects," Medical and Biological Engineering & Computing, Vol. 29 Supplement, July 1991, p.664

Della Santina CC, DeAngelis GC, and Lehman S, “Exploring neuromotor control of the forearm reaction to perturbation,” IEEE Engineering in Medicine and Biology Society 1989 Annual Intl Conf, Seattle

Published Book Chapters

Della Santina CC, Carey JP, Minor LB, (in press) “The Vestibular System,” in Essential Otolaryngology, 9th Edn (Editor KJ Lee). McGraw-Hill. 2008.

Della Santina CC, Carpenter R, Niparko JK, “Cochlear Implants and Implantable Hearing Devices,” in Clinical Otology, 3rd Edn (Editors G. Hughes & M. Pensak). Thieme. 2007.

Carey JP and Della Santina CC, “Vestibular Physiology,” in Otolaryngology – Head & Neck Surgery, 4th Edn (Editor C.W. Cummings), Mosby. 2005.

Della Santina CC and Lustig LR and “Implantable Hearing Aids,” in Otolaryngology – Head & Neck Surgery, 4th Edn (Editor C.W. Cummings). Mosby. 2005.