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Basic and Translational Research

The Research Division and its faculty members are recognized internationally as leading innovators in musculoskeletal science and training. Our program is consistently ranked as one of the top five National Institutes of Health (NIH)-funded musculoskeletal programs within the United States, and our modern training programs are seen as the vanguard for producing the next generation of musculoskeletal scientists.

Our investigators conduct basic and translational research in topics that represent the great diversity of problems that impact the musculoskeletal system. Focus areas include integrative musculoskeletal biology, stem cells and regenerative medicine, skeletal neurobiology, bone metastasis and clinical outcomes.

Our Basic and Translational Researchers

Photo of Dr. Stephen M. Belkoff, Ph.D.

Belkoff, Stephen M., Ph.D.

Associate Professor of Orthopaedic Surgery
Director, Orthopaedic Instrumentation Laboratory
Director, International Center for Orthopaedic Advancement
Research Interests: Joint reconstruction, Mechanics of fracture fixation, Mechanism of injury, Trauma biomechanics, Soft-tissue characterization, Vertebroplasty
 
Photo of Dr. Thomas M. Brushart, M.D.

Brushart, Thomas M., M.D.

Professor of Orthopaedic Surgery
Professor of Neurology
Professor of Plastic and Reconstructive Surgery
Brushart Professor of Hand Surgery
Expertise, Disease and Conditions: Arthritis of the Hand, Carpal Tunnel Syndrome, Cubital Tunnel Syndrome, Dupuytren's Contracture, Hand Conditions, Hand Surgery, Inclusion Body Myositis, Microsurgical Nerve Repair, Nerve Compression, Nerve Injury, Orthopaedic Surgery, Orthopaedics, Perinatal Brachial Plexus Injury, Peripheral Nerve Disorders, Ulnar Neuropathy
Research Interests: Peripheral Nerve Regeneration
 
Photo of Dr. Xu Cao, Ph.D.

Cao, Xu, Ph.D.

Professor of Orthopaedic Surgery
Lee Riley Professor, Department of Orthopaedic Surgery
Director, Center for Musculoskeletal Research
Research Interests: Osteoarthritis, Osteoporosis, Bone remodeling, Mesenchymal stem cells
 
Photo of Dr. Thomas Landes Clemens, Ph.D.

Clemens, Thomas Landes, Ph.D.

Professor of Orthopaedic Surgery
Lewis Cass Spencer Professor of Orthopaedic Surgery
Director of Research, Department of Orthopaedic Surgery
Senior Research Career Scientist, Baltimore Veterans Administration Medical Center
Research Interests: Skeletal repair, Skeletal development, Osteogenesis, Musculoskeletal biology
 
Photo of Dr. Douglas J. Digirolamo, Ph.D.

Digirolamo, Douglas J., Ph.D.

Assistant Professor of Orthopaedic Surgery
Research Interests: Musculoskeletal biology
 
Photo of Dr. Lynne C. Jones, M.S., Ph.D.

Jones, Lynne C., M.S., Ph.D.

Associate Professor of Orthopaedic Surgery
Director, Center for Osteonecrosis Research and Education
Director of Resident Research
Director, Hip & Knee Surgery Research
Research Interests: Osteonecrosis, Total Joint Replacement, Bone Graft and Bone Graft Substitutes, Animal models of musculoskeletal disease
 
Photo of Dr. Scott Lee Kominsky, Ph.D.

Kominsky, Scott Lee, Ph.D.

Associate Professor of Orthopaedic Surgery
Associate Professor of Oncology
Director of Research Education
Assistant Director, Basic Science Laboratory
Research Interests: Novel prophylactic and therapeutic modalities for bone metastasis, Mechanisms of metastatic tumor cell homing to and growth in bone, Molecular genetics of breast cancer
 
Photo of Dr. Ryan Christopher Riddle, Ph.D.

Riddle, Ryan Christopher, Ph.D.

Assistant Professor of Orthopaedic Surgery
Director, Bone Biology subcore of Diabetes Research Center
Research Interests: Musculoskeletal development, Skeletal metabolism, Wnt signaling
 
Photo of Dr. Richard Leroy Skolasky, Jr., M.A., Sc.D.

Skolasky, Richard Leroy, M.A., Sc.D. Jr.

Associate Professor of Orthopaedic Surgery
Associate Professor of Physical Medicine and Rehabilitation
Director, Spine Outcomes Research Center
Research Interests: Spine biomechanics, Psycho-social determinates of health, Health disparities, Health services research, Functional outcomes of spine surgery
 
Photo of Dr. Mei Wan, Ph.D.

Wan, Mei, Ph.D.

Professor of Orthopaedic Surgery
Research Interests: parathyroid hormone, LRP6, bone marrow mesenchymal stem/progenitor cells, tissue repair/remodeling, stem cell mobilization
 
Photo of Dr. Feng-Quan Zhou, Ph.D.

Zhou, Feng-Quan, Ph.D.

Associate Professor of Orthopaedic Surgery
Associate Professor of Neuroscience
Research Interests: Live cell imaging of signal transduction and cytoskeletal reorganization in neurons, Epigenetic regulation of neuronal morphogenesis during development and regeneration, Promoting axon regeneration after spinal cord or brain injuries, GSK3 signaling in neural development
 
 

Our Labs

  • Spine Outcomes Research Center

    The Spine Outcomes Research Center is a multidisciplinary group committed to improving patient outcomes and applying high-quality and purposeful research to professional practice. The organization values collegial interaction and strong scientific principles.

  • Zhou Lab

    In the Zhou Lab, the overall goal of our research is to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, we are interested in understanding how neurons generate their complex morphology and form proper circuitries during development and how neurons regenerate to restore connections after brain or spinal cord injuries.