Researchers at Johns Hopkins are constantly advancing science through basic, translational and clinical investigations. Here are highlights of our most current findings.
New Uses Possible for Breast Cancer Drug
Exemestane, a synthetic steroid drug widely prescribed to fight breast cancers that thrive on estrogens, not only inhibits the production of the hormone, but also appears to protect cells throughout the body against damage induced by UV radiation, inflammation and other assaults, according to new research from Johns Hopkins scientists.
Genes Involved in Pediatric Brain Tumors Identified
Investigators at Johns Hopkins have found a known genetic pathway to be active in many difficult-to-treat pediatric brain tumors called low-grade gliomas. Testing of a drug in glioma cells confirmed that the pathway could be a new target for the treatment of these cancers.
A Single Deleted Gene Causes Imbalance for Other Genes
Researchers found that the deletion of any single gene in yeast cells puts pressure on the organism’s genome to compensate, leading to a mutation in another gene. The discovery will likely have significant consequences for human genetics research, especially cancer research, because of the way DNA is conserved across species.
Survival Signals for Newborn Brain Cells
Johns Hopkins researchers report that a special type of brain cell sends signals that tamp down stem cell activity but encourage the survival of the stem cells' progeny, newborn brain cells. The research has implications for treating neurodegenerative disease and mental illness.
Best Practice: Remove Catheters in Newborns ASAP
A new study led by Johns Hopkins Children’s Center investigators shows that clinicians can reduce the risk of dangerous bloodstream infections in newborns with central venous catheters by ending use of the device as soon as possible, rather than waiting to remove it after signs of infection are seen.