I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
Home > News and Publications > JHM Publications > Psychiatry Newsletter > Hopkins BrainWise - Winter 2014
Psychiatry Newsletter - For Mild TBI: An Eye on the Sleepy
Hopkins BrainWise - Winter 2014
For Mild TBI: An Eye on the Sleepy
Date: December 16, 2013
Problem sleep could be a good early marker for lasting mood and other psychiatric problems of mild TBI, Vani Rao believes. “But more important, we’re hoping it will lead us to prevent that distress.”
Most patients with mTBI—mild traumatic brain injury—recover. They may experience headache, difficulties in sleeping, memory or thinking, for example, but in a fortunate 70 to 80 percent, “those signs that they’ve had a brain injury go away,” says psychiatrist Vani Rao, who directs Psychiatry’s Brain Injury Program.
Yet for patients who don’t snap back, life can nosedive. “Perhaps 20 percent continue to suffer neuropsychiatric symptoms,” says Rao. The anxiety, depression or wayward cognition—even when the latter is subtle—dismantle day to day function.
Now Rao and colleagues are researching how to improve the outlook for all mTBI patients. Recently, they made a significant step—an answer to what Rao calls “the million dollar question,” namely, who, exactly, will recover? And it appears to lie in noting the sleep difficulties that begin soon after mTBI’s causal injury.
“We see a lot of patients with mTBI who struggle with falling asleep or maintaining it. Or daytime sleepiness interferes with their work,” she says. Other clinicians back up Rao’s observations. And earlier, her team confirmed this in a study of roughly 50 patients seen within three months of their injury.
In the recent work, Rao and Johns Hopkins colleagues including Una McCann and Michael Smith showed that these early sleep disturbances can predict who’s still likely to have increased anxiety, depression and/or apathy a year later. The results held both for mild and more severe TBI.
What underlies the poor sleep? Rao can’t say for sure. It may be pain from bodily injuries. “Or perhaps painkillers or other medication is at fault,” she adds. “Mostly, though, we suspect subtle neuronal injury to the brain.” After the initial injury, a cascade of changes take place—most not picked up by usual brain scans or standard cognitive testing.
These changes precede the sleep symptoms. An earlier study by Rao enrolled seven people within a week of their traumatic event. They underwent a two-day sleep study with a polysomnogram of their responses. Those who’d later be diagnosed with TBI had sleep patterns far from normal.
“So sleep changes can help diagnose mTBI,” Rao explains, “as well as predict its outcome.
“Our next step is to see if treating sleep problems early on lessens or even prevents psychiatric symptoms and the distress they bring. That would be a real a find because we know how to treat sleep problems.”
For information: 410-550-2288