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School of Medicine
Promise and Progress - Personalized Chemotherapy
Reprogramming Cancer Cells - The Story of Epigenetics
Issue No. 1
Issue No. 1
Date: July 16, 2014
Clinical Cancer Research, January 2013
Scientists have used patients’ own tumors, grown in mouse models and then transferred to culture flasks to identify the chemotherapy drugs that will work best against the cancer. Cancer drugs are typically selected based on the affected organ or the appearance and activity of cancer cells under a microscope. This process creates cell lines that very accurately represent the patient’s tumor and can be tested against any drug library in the world to pinpoint agents that will get the best response. In one experiment involving a pancreas cell line, James Eshleman, M.D., Ph.D., Elizabeth Jaffee, M.D., Ralph Hruban, M.D., and team successfully identified two drugs active against the cancer from a library of more than 3,000 drugs.
The research was funded by the National Institutes of Health’s National Cancer Institute grants CA 130938, CA 62924 and CA 122581, the Sol Goldman Pancreatic Cancer Research Center, the Stewart Trust Fund, the Lustgarten Foundation, the Mary Lou Wootton Pancreatic Cancer Research Fund, the Michael Rolfe Pancreatic Cancer Foundation, and the HERA Women’s Cancer Foundation.
Articles in this Issue
- Headline Makers - Overview
- A Safer Way to Treat Pediatric Brain Cancers
- For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
- Blood Cells Transformed to Repair Damaged Retina
- Personalized Chemotherapy
- 3D Scans Show whether Treatment is Working
- Alcohol Metabolite Could Increase Cancer Risk in Some People
- Acupuncture, Real or Simulated, Eases Hot Flashes
- New Leukemia Findings
- HPV Oral Cancers and Risk of Infection for Couples
- Molecular Marker of Cancer Drug Response
- Chronic Inflammation Connected to Prostate Cancer
- Fat Versus Brain Cancer
- DNA Damaging Toxins In Food
- Cancer Patients Who Quit Smoking Live Longer
- New Immune Therapy Shows Promise Against Melanoma
- Breathe Easier and Fight Cancer
- Cost-Cutting and Excellent Care Not Mutuallly Exclusive
- The Key to Safe Bone Marrow Transplants Revealed
- Gene-Based Blood Tests Detect Advanced and Early Cancers