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School of Medicine
Promise and Progress - Molecular Marker of Cancer Drug Response
Reprogramming Cancer Cells - The Story of Epigenetics
Issue No. 1
Issue No. 1
Molecular Marker of Cancer Drug Response
Date: July 16, 2014
PLOS ONE, July 2013
Researchers uncovered a molecular biomarker that can accurately predict patients who will best respond to a class of common anticancer drugs known as EGFR inhibitors. In studies of a variety of tumors with EGFR mutations, high levels of a protein called Mig 6 predicted tumors that would not respond to EGFR inhibitors. Mig 6 helps control the expression of EGFR, and they found that as Mig 6 levels increased so did resistance to EGFR-inhibitor drugs.
Lead researcher David Sidransky, M.D., and team, including Atul Bedi, M.D., David Berman, M.D., Ph.D., and Steven Goodman, M.D., Ph.D., say the beauty of the finding is its simplicity in transferring it to the clinic, noting that EGFR inhibitors could be targeted to patients with low levels of Mig 6. EGFR inhibitors are commonly prescribed for lung cancer patients whose tumors have EGFR mutations. This new finding helps explain why patients’ responses have been so varied, ranging from no survival benefit to several years and provides the first reliable method for identifying patients most likely to benefit. Further tests of the Mig 6 marker in larger groups of patients are planned.
The research was funded by the National Institutes of Health’s National Cancer Institute grants P50 DE019032, U01 CA 084986, and R37DE012588 and the Flight Attendant Medical Research Institute.
Articles in this Issue
- Headline Makers - Overview
- A Safer Way to Treat Pediatric Brain Cancers
- For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
- Blood Cells Transformed to Repair Damaged Retina
- Personalized Chemotherapy
- 3D Scans Show whether Treatment is Working
- Alcohol Metabolite Could Increase Cancer Risk in Some People
- Acupuncture, Real or Simulated, Eases Hot Flashes
- New Leukemia Findings
- HPV Oral Cancers and Risk of Infection for Couples
- Molecular Marker of Cancer Drug Response
- Chronic Inflammation Connected to Prostate Cancer
- Fat Versus Brain Cancer
- DNA Damaging Toxins In Food
- Cancer Patients Who Quit Smoking Live Longer
- New Immune Therapy Shows Promise Against Melanoma
- Breathe Easier and Fight Cancer
- Cost-Cutting and Excellent Care Not Mutuallly Exclusive
- The Key to Safe Bone Marrow Transplants Revealed
- Gene-Based Blood Tests Detect Advanced and Early Cancers