Search the Health Library
Get the facts on diseases, conditions, tests and procedures.
I Want To...
Find a Doctor
Find a doctor at The Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center or Johns Hopkins Community Physicians.
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
Promise and Progress - For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
Issue No. 1
For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
Date: July 16, 2014
Science Translational Medicine, January 2014
An early clinical study showed that a vaccine used to treat women with high-grade precancerous cervical lesions causes an immune cell response within the precancerous cervical cells. The study found that measuring immune system responses in the cervical lesions identified immune responses that were not detectable in the blood. Tissue immune biomarkers could more accurately evaluate if the therapeutic vaccine is working. The study led by Kimmel Cancer Center cervical cancer expert, Cornelia Trimble, M.D., involved 12 patients who received vaccine therapy for a common type of cervical precancers. Examination of cervical tissue showed more accurate pre- and post-vaccination response than blood samples.
Funding for the research and clinical trials was provided by the National Institutes of Health’s National Cancer Institute grants CA 123876, CA 14269101, CA098252, and CA0006973, and the Dana Foundation.
Articles in this Issue
- Headline Makers - Overview
- A Safer Way to Treat Pediatric Brain Cancers
- For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
- Blood Cells Transformed to Repair Damaged Retina
- Personalized Chemotherapy
- 3D Scans Show whether Treatment is Working
- Alcohol Metabolite Could Increase Cancer Risk in Some People
- Acupuncture, Real or Simulated, Eases Hot Flashes
- New Leukemia Findings
- HPV Oral Cancers and Risk of Infection for Couples
- Molecular Marker of Cancer Drug Response
- Chronic Inflammation Connected to Prostate Cancer
- Fat Versus Brain Cancer
- DNA Damaging Toxins In Food
- Cancer Patients Who Quit Smoking Live Longer
- New Immune Therapy Shows Promise Against Melanoma
- Breathe Easier and Fight Cancer
- Cost-Cutting and Excellent Care Not Mutuallly Exclusive
- The Key to Safe Bone Marrow Transplants Revealed
- Gene-Based Blood Tests Detect Advanced and Early Cancers