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School of Medicine
Promise and Progress - Breathe Easier and Fight Cancer
Reprogramming Cancer Cells - The Story of Epigenetics
Issue No. 1
Issue No. 1
Breathe Easier and Fight Cancer
Date: July 16, 2014
Interfering with a newly-discovered immune target appears to both help prevent asthma and fight tumors.
Kimmel Cancer Center cancer immunology expert Jonathan Powell, M.D., found that removing an enzyme, known as SGK1, in mouse models, caused resistance to dust mite-related asthma and about a 50 percent reduction in numbers of lung tumors developed. Dr. Powell believes that a drug that could block the enzyme in humans could potentially be used to inhibit asthma and also as a novel therapeutic approach that would bolster immune attacks against cancer.
The interesting dual disease affect stems from the immune role of SGK1, Dr. Powell and team say. SGK1 promotes the production of a type of immune cell that is overactive in asthma but hinders production of immune cells needed to fight tumors. Blocking the enzyme disrupts this process resulting in the anti-asthma and anti-tumor response the scientists observed.
The research was funded by the National Institutes of Health grant R01 A177610, the American Asthma Foundation, the American Medical Association Foundation Seed Grant, and the Flight Attendant Medical Research Institute
Articles in this Issue
- Headline Makers - Overview
- A Safer Way to Treat Pediatric Brain Cancers
- For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
- Blood Cells Transformed to Repair Damaged Retina
- Personalized Chemotherapy
- 3D Scans Show whether Treatment is Working
- Alcohol Metabolite Could Increase Cancer Risk in Some People
- Acupuncture, Real or Simulated, Eases Hot Flashes
- New Leukemia Findings
- HPV Oral Cancers and Risk of Infection for Couples
- Molecular Marker of Cancer Drug Response
- Chronic Inflammation Connected to Prostate Cancer
- Fat Versus Brain Cancer
- DNA Damaging Toxins In Food
- Cancer Patients Who Quit Smoking Live Longer
- New Immune Therapy Shows Promise Against Melanoma
- Breathe Easier and Fight Cancer
- Cost-Cutting and Excellent Care Not Mutuallly Exclusive
- The Key to Safe Bone Marrow Transplants Revealed
- Gene-Based Blood Tests Detect Advanced and Early Cancers