Search the Health Library
Get the facts on diseases, conditions, tests and procedures.
I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
Home > News and Publications > JHM Publications > Promise and Progress > Reprogramming Cancer Cells - The Story of Epigenetics
Promise and Progress - A Safer Way to Treat Pediatric Brain Cancers
Reprogramming Cancer Cells - The Story of Epigenetics
Issue No. 1
Issue No. 1
A Safer Way to Treat Pediatric Brain Cancers
Date: July 16, 2014
Neuro-Oncology, November 2013
Activity in a known genetic pathway was linked to difficult-to-treat pediatric brain cancers, known as low-grade gliomas. Pediatric cancer clinician-scientist Eric Raabe, M.D., Ph.D., and neuropathologists Fausto Rodriguez, M.D., and Charles Eberhart, M.D., Ph.D., found in laboratory studies that the mTOR pathway was highly active in these pediatric cancers and used an experimental drug to block mTOR signaling. It resulted in decreased growth of the tumors.
Low-grade gliomas are the most common group of tumors of the central nervous system in children. Therapy, which typically includes surgery and chemotherapy, can cause significant side effects, such as blindness, paralysis, and learning disorders. Dr. Raabe’s work is focused on finding better and safer treatments. He plans to begin animal studies and test additional mTOR inhibitors.
The research was funded by The Childhood Brain Tumor Foundation, the PLGA Foundation, the Pilocytic/Pilomyxoid Fund, the St. Baldrick’s Foundation, the Knights Templar Eye Foundation, and Ian’s Friend Foundation.
Articles in this Issue
- Headline Makers - Overview
- A Safer Way to Treat Pediatric Brain Cancers
- For Cervical Lesions, Tissue Exam Beats Conventional Blood Tests
- Blood Cells Transformed to Repair Damaged Retina
- Personalized Chemotherapy
- 3D Scans Show whether Treatment is Working
- Alcohol Metabolite Could Increase Cancer Risk in Some People
- Acupuncture, Real or Simulated, Eases Hot Flashes
- New Leukemia Findings
- HPV Oral Cancers and Risk of Infection for Couples
- Molecular Marker of Cancer Drug Response
- Chronic Inflammation Connected to Prostate Cancer
- Fat Versus Brain Cancer
- DNA Damaging Toxins In Food
- Cancer Patients Who Quit Smoking Live Longer
- New Immune Therapy Shows Promise Against Melanoma
- Breathe Easier and Fight Cancer
- Cost-Cutting and Excellent Care Not Mutuallly Exclusive
- The Key to Safe Bone Marrow Transplants Revealed