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Promise and Progress - Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
Faces of Childhood Cancer
Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
Date: June 1, 2004
Journal of National Cancer Institute, December 3, 2003
Researchers are investigating interactions between the commonly used breast cancer drug tamoxifen and the antidepressant drug paroxetine, used to treat hot flashes. The interactions could potentially alter the effectiveness of tamoxifen. A team of scientists from the Johns Hopkins Kimmel Cancer Center, Indiana University and the University of Michigan found that women taking both drugs had decreased levels of a newly identified molecule called endoxifen, a byproduct of tamoxifen in its processed form, which could indicate that the tamoxifen is not being fully metabolized in these people.
“Right now, these results do not change current treatment recommendations for women on adjuvant tamoxifen therapy who are dealing with hot flashes,” says Vered Stearns, M.D., assistant professor of oncology at the Kimmel Cancer Center and lead investigator in the study. “We need larger studies to understand the impact of endoxifen and CYP2D6 on tamoxifen’s effectiveness.”
Check our Web site and the next issue of Promise & Progress for new updates on this and other research presented at the 2004 American Society of Clinical Oncology (ASCO) meeting.
This research was funded by the National Institutes of Health, the Damon Runyon Cancer Research Foundation, Fashion Footwear Association of New York and GlaxoSmithKline Pharmaceuticals.
Articles in this Issue
- Gene Hunters Pinpoint New Cancer Gene Target
- Faces of Childhood Cancer
- Clinical Trial in the Spotlight
- A Fighting Chance
- A Champion of Pediatric Cancer Research
- One Physician's Quest for a Treatment for the Worst Kind of Pediatric Brain Tumor
- Origin of Multiple Myeloma Found in Rare Stem Cell
- Experimental Drug Being Tested for Acute Myeloid Leukemia
- 'Switched-Off' Genes May Put First Chink in Colon Cell's Anti-Tumor Armor
- Against All Odds: Ariana's Story
- From the Laundry Room to the Laboratory
- In Lauren's Head
- Pediatric Oncology Friends Bring Rhyme and Reason to Pediatric Cancer Research
- Optimists Provide Landmark Gift to Children's Cancer Research
- Eli Kahn
- Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
- Premature Aging Gene Could Have Implications for New Cancer Therapies
- Something's Fishy in Cancer Research
- Angiogenesis Gene Linked to Boimarkers in Breast Cancer
- A Cure is More than the Eradication of Cancer
- Arsenic Part of Novel Treatment for Leukemia