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School of Medicine
Promise and Progress - Gene Hunters Pinpoint New Cancer Gene Target
Faces of Childhood Cancer
Gene Hunters Pinpoint New Cancer Gene Target
Date: June 1, 2004
Science, March 11, 2004
Investigators have identified mutations in a gene known as PIK3CA and linked them to the progression of colon and other cancers. Their discovery identifies this gene as one of the most highly mutated genes in human cancer that could serve as a target for new cancer therapies and diagnostic tests. The PIK3CA gene is part of a family of genes that encode lipid kinases, enzymes that modify fatty molecules and direct cells to grow, change shape or move. “Kinases have been the focus of recent drug development strategies, with some kinase-inhibiting compounds, like Gleevec and Herceptin, already being used in patients to block tumor growth,” says Victor Velculescu, M.D., who is leading the study. Velculescu and team are now studying the role of the gene in tumor progression more closely and working to identify drugs to target tumors with the mutation.
This research was funded by the Ludwig Trust, the Benjamin Baker Scholarship Fund, the EMBO Fellowship Fund and the National Institutes of Health.
Articles in this Issue
- Gene Hunters Pinpoint New Cancer Gene Target
- Faces of Childhood Cancer
- Clinical Trial in the Spotlight
- A Fighting Chance
- A Champion of Pediatric Cancer Research
- One Physician's Quest for a Treatment for the Worst Kind of Pediatric Brain Tumor
- Origin of Multiple Myeloma Found in Rare Stem Cell
- Experimental Drug Being Tested for Acute Myeloid Leukemia
- 'Switched-Off' Genes May Put First Chink in Colon Cell's Anti-Tumor Armor
- Against All Odds: Ariana's Story
- From the Laundry Room to the Laboratory
- In Lauren's Head
- Pediatric Oncology Friends Bring Rhyme and Reason to Pediatric Cancer Research
- Optimists Provide Landmark Gift to Children's Cancer Research
- Eli Kahn
- Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
- Premature Aging Gene Could Have Implications for New Cancer Therapies
- Something's Fishy in Cancer Research
- Angiogenesis Gene Linked to Boimarkers in Breast Cancer
- A Cure is More than the Eradication of Cancer
- Arsenic Part of Novel Treatment for Leukemia