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School of Medicine
Promise and Progress - Clinical Trial in the Spotlight
Faces of Childhood Cancer
Clinical Trial in the Spotlight
Date: June 1, 2004
Clinical vaccine for chronic leukemia being studied
Johns Hopkins Kimmel Cancer Center researchers are testing a vaccine to recruit the immune system in fighting chronic myeloid leukemia (CML). The Phase I/II study will test the vaccine in 20 patients who have been taking the anticancer drug Gleevec for one year but may still have detectable disease in their blood.
Follow-up data show that the disease comes back in many leukemia patients taking Gleevec, an oral drug that interferes with the cellular pathways that signal tumor cell growth, and most patients still have leukemia cells circulating in their blood. These patients may appear healthy, but could relapse with time.
Researchers will monitor patients for three months and if leukemic cells are detected, administer four doses of vaccine over nine weeks. The vaccinated patients will be monitored for another 36 weeks.
The vaccine uses lab-grown irradiated chronic myeloid leukemia cells genetically modified with the immune-boosting gene GM-CSF. Immune cells are attracted to the vaccine and recognize its antigens, which serve as red flags that cause the immune system to seek out and destroy cancer cells elsewhere in the body. n For more information, contact:
Hyam Levitsky, M.D. 410-614-0552
Karen Friel 410-502-7114.
Articles in this Issue
- Gene Hunters Pinpoint New Cancer Gene Target
- Faces of Childhood Cancer
- Clinical Trial in the Spotlight
- A Fighting Chance
- A Champion of Pediatric Cancer Research
- One Physician's Quest for a Treatment for the Worst Kind of Pediatric Brain Tumor
- Origin of Multiple Myeloma Found in Rare Stem Cell
- Experimental Drug Being Tested for Acute Myeloid Leukemia
- 'Switched-Off' Genes May Put First Chink in Colon Cell's Anti-Tumor Armor
- Against All Odds: Ariana's Story
- From the Laundry Room to the Laboratory
- In Lauren's Head
- Pediatric Oncology Friends Bring Rhyme and Reason to Pediatric Cancer Research
- Optimists Provide Landmark Gift to Children's Cancer Research
- Eli Kahn
- Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
- Premature Aging Gene Could Have Implications for New Cancer Therapies
- Something's Fishy in Cancer Research
- Angiogenesis Gene Linked to Boimarkers in Breast Cancer
- A Cure is More than the Eradication of Cancer
- Arsenic Part of Novel Treatment for Leukemia