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School of Medicine
Promise and Progress - Angiogenesis Gene Linked to Boimarkers in Breast Cancer
Faces of Childhood Cancer
Angiogenesis Gene Linked to Boimarkers in Breast Cancer
Date: June 1, 2004
Kimmel Cancer Center scientists have made what is believed to be the first link between a gene that controls blood vessel growth and increased activity in a panel of breast cancer biomarkers that regulate tumor cell growth.
The HOXB7 (or homeobox B7) gene appears to drive tumor development by increasing the production of growth factors that affect blood vessel development, according to study director Saraswati Sukumar, Ph.D., Barbara Rubenstein Professor of Oncology. Her team found increased production of messenger molecules directed by the HOXB7 gene in more than 60 percent of breast cancer cell lines and 90 percent of primary breast cancers. They also found that the gene is important in initiating cancer cells to move from their primary site to metastatic sites. Their microarray data has shown that HOXB7 gene expression is low or undetectable in normal breast tissue, and is expressed five to seven times higher in primary tumors and up to 20 times higher in bone metastasis.
“We also found that turning on the HOXB7 gene causes overproduction of a family of breast cancer markers called receptor tyrosine kinases,” says Sukumar. “So we believe HOXB7 is important for the early development of breast cancer and may be a good target for detection and therapeutic tools.”
Articles in this Issue
- Gene Hunters Pinpoint New Cancer Gene Target
- Faces of Childhood Cancer
- Clinical Trial in the Spotlight
- A Fighting Chance
- A Champion of Pediatric Cancer Research
- One Physician's Quest for a Treatment for the Worst Kind of Pediatric Brain Tumor
- Origin of Multiple Myeloma Found in Rare Stem Cell
- Experimental Drug Being Tested for Acute Myeloid Leukemia
- 'Switched-Off' Genes May Put First Chink in Colon Cell's Anti-Tumor Armor
- Against All Odds: Ariana's Story
- From the Laundry Room to the Laboratory
- In Lauren's Head
- Pediatric Oncology Friends Bring Rhyme and Reason to Pediatric Cancer Research
- Optimists Provide Landmark Gift to Children's Cancer Research
- Eli Kahn
- Possible Interaction Identified Between Tamoxifen and Hot Flash Drug
- Premature Aging Gene Could Have Implications for New Cancer Therapies
- Something's Fishy in Cancer Research
- Angiogenesis Gene Linked to Boimarkers in Breast Cancer
- A Cure is More than the Eradication of Cancer
- Arsenic Part of Novel Treatment for Leukemia