Investigators at the Johns Hopkins University School of Medicine’s Brain Injury Outcomes program and the Institute for Clinical and Translational Research have been awarded a seven-year, $25 million grant from the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS) to form, along with Tufts University School of Medicine, one of three Trial Innovation Centers.

It is estimated that approximately one in eight women will be diagnosed with breast cancer in her lifetime. With that statistic, knowledge is certainly power — from understanding prevention and screening to learning more about survivorship, our experts at Johns Hopkins Medicine and the Johns Hopkins Kimmel Cancer Center can provide the information needed to understand all aspects of breasts cancer.

In efforts to develop new treatments for brain cancer, scientists from Johns Hopkins Drug Discovery and the Kimmel Cancer Center's Bloomberg~Kimmel Institute for Cancer Immunotherapy report they have altered the structure of an experimental drug that seems to enhance its ability to slip through the mostly impermeable blood-brain barrier. Results of their proof-of-concept experiments in monkeys, published Aug. 25 in the Journal of Medicinal Chemistry, show a tenfold better delivery of the drug to the brain compared with the rest of animals’ bodies.  

In an effort to improve antibiotic use, the Agency for Healthcare Research and Quality within the U.S. Department of Health and Human Services has awarded the Johns Hopkins Armstrong Institute for Patient Safety and Quality a $16 million contract to identify which approaches are most helpful and to operationalize efforts to optimize antibiotic prescribing.

Paul B. Rothman, M.D., and Jeffrey P. Kahn, Ph.D., M.P.H., of Johns Hopkins have been elected to the National Academy of Medicine (NAM).

Johns Hopkins Medicine, in partnership with the Johns Hopkins University Applied Physics Laboratory, today announced a joint effort to apply rigorous data analysis and systems engineering practices in an effort to revolutionize the diagnosis and treatment of disease.

For the first time, all 10 Johns Hopkins Health System entities — spanning Maryland; Washington, D.C.; Virginia; and Florida — are coming together to host a Johns Hopkins-wide nursing job fair.

Pediatric critical care specialists at Johns Hopkins report that a test of their pilot program to reduce sedation and boost early mobility for children in an intensive care unit proves it is both safe and effective.

After analyzing 10 years of medical tests on more than 2,700 people in a federally funded heart disease study, researchers at Johns Hopkins Medicine and elsewhere conclude that taking calcium in the form of supplements may raise the risk of plaque buildup in arteries and heart damage, although a diet high in calcium-rich foods appears be protective.

Researchers led by Johns Hopkins Kimmel Cancer Center scientists report they have developed a free web-based app that could take some of the guesswork out of decisions to order an additional and costly molecular test for assessing risk for recurrence in women with early stage breast cancer.

Drugs called PARP inhibitors, which sabotage cancer cells’ ability to repair damage to their DNA, have shown some promise in treating human breast cancers that contain BRCA1 and BRCA2 gene mutations. Now, a new study in lab-grown cancer cells and mice suggests that their effectiveness could be strengthened and expanded to other forms of breast cancer and leukemia not linked to BRCA mutations by adding a so-called epigenetic drug.

A new study suggests that a specialized area of the mosquito brain mixes tastes with smells to create unique and preferred flavors. The findings advance the possibility of identifying a substance that makes “human flavor” repulsive to the malaria-bearing species of the mosquitoes, so instead of feasting on us, they keep the disease to themselves, potentially saving an estimated 450,000 lives a year worldwide.

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer’s. Now, researchers at Johns Hopkins say they have pinpointed the protein at the end of that chain of events, one that delivers the fatal strike by carving up a cell’s DNA. The find, they say, potentially opens up a new avenue for the development of drugs to prevent, stop or weaken the process.

In a collaborative effort with scientists at six Colombian hospitals, Johns Hopkins Medicine researchers report what they believe to be the strongest biological evidence to date linking Zika virus infection and Guillain-Barré syndrome.

A new study by a team of Johns Hopkins researchers found that most survivors of acute respiratory distress syndrome (ARDS) decline physically in the five years after hospital discharge, and those at higher levels of risk of decline are older and had greater medical problems prior to hospitalization for ARDS.

Johns Hopkins Medicine today announced that six of the region’s largest and most prominent health systems are investing in its Medicare managed care health plans, which offer comprehensive health care coverage to Medicare-eligible beneficiaries in 11 counties in Maryland.

Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung’s disease. The results of their latest study suggest that many patients develop the disease when multiple mutations in gene regulatory sequences of a specific gene combine to destroy the normal cooperative function of a whole network of genes. 

Researchers at Johns Hopkins report they have identified a protein that enables a toxic natural aggregate to spread from cell to cell in a mammal’s brain — and a way to block that protein’s action.

Johns Hopkins HealthCare Solutions, a part of Johns Hopkins Medicine, today announced the opening of its 55^th onsite employee health and wellness center for The Coastal Companies. A leading processor and distributor of produce and dairy in the Mid-Atlantic region employing more than 1,000 people, The Coastal Companies has chosen Johns Hopkins to operate the crew member clinic at the company’s 330,000 square foot food distribution center in Laurel, Maryland.

Johns Hopkins Community Physicians celebrates the opening of a new, state-of-the-art medical facility with a ceremonial ribbon-cutting event.