Our research in HIV/NeuroAIDS has focused on developing in-vitro models for studies of neuroglia function. We have developed a human brain organotypic culture system that allow us to study models of HIV infection and the role of neuroglia and blood vessel interaction during such infection.
Laser confocal imaging of a HIV-infected monocyte (red cell) and its interaction with a blood vessel in an in-vitro model of brain infection.
Most recently, we have focused on the development of a similar in-vitro infection model for studies of progressive multifocal leukoencephalopathy by using JC viruses to infect neuroglial cells. This model will be very useful for studies of the biology of a rare and usually fatal viral disease known as progressive multifocal leukoencephalopathy (PML). It will also be useful in identifying potential treatment approaches. Collaborators include Drs. Carlos Pardo and Justin McArthur.