Skip Navigation
 
 
 
 xxx
 
Print This Page
Share this page: More
 

Understanding How Myelin Protects Axons

Myelin is wrapped around axons (nerves) and serves to protect the nerves and to enhance nerve transmission. Myelin, as well as the underlying axon, is a target of damage in MS. Myelin is made up of fats and proteins. We continue to study how a myelin protein, called MAG, and a newly identified cousin, called Netrin, can communicate with the axon (nerve fiber) and protect it from damage (Nguyen et al J. Neuroscience, 2009). 

Understanding how myelin protects axons could lead to novel ways of protecting or repairing nerves without necessarily having to make new myelin.  This research is now unraveling the molecular details of how this crosstalk between MAG and axons occurs. Collaborators in this work include Dr. Peter Calabresi.

MAG prevenst axonal degeneration

MAG (top row) prevents axonal degeneration that ensues overtime as seen in the control (lower row).

 

TM and MS Research

Discover how FOX Sports Supports is helping to raise awareness about autoimmune disease research
Learn more.

Related Links

Attacking Two Brain Disorders on Multiple Fronts
Uncover how Hopkins researchers are finding new treatments and diagnostic tools to treat multiple sclerosis and transverse myelitis.

Looking Forward

Looking Forward

Previous Issues

 

Out-of-State and International Patients - Find Out More

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer