Skip Navigation
Search Menu
Neurology and Neurosurgery

In This Section      
Print This Page

Upcoming Studies

Intranasal Insulin Therapy for HIV-associated Neurocognitive Disorders

Purpose: The future treatment for HAND will likely need to include both antiretroviral therapy and adjunctive therapy to treat central nervous system (CNS) specific pathogenetic mechanisms. Insulin is involved in multiple CNS functions including food intake, metabolism, learning, and memory. Insulin has neuroprotective properties demonstrated in cell culture experiments and in vivo models, which provide strong evidence for its use as a therapeutic agent to treat HAND. The brain delivery of insulin administered via a novel nasal drug delivery device has been shown to have CNS protective, restorative, and cognitive enhancing effects in over 15 independent clinical studies. In addition to standard neuropsychological testing, the proposed clinical trial will use several novel brain imaging and CSF surrogate markers to monitor the effects of intranasal insulin therapy in HAND patients.  We will conduct a 24 week double-blinded, placebo-controlled Phase I/II trial of intranasal insulin for the treatment of HAND. Participants will be randomly assigned to one of two groups: 1) Intranasal insulin, or 2) placebo administered with a nasal drug delivery device.  Outcomes from these studies could have important implications for the design and implementation of future insulin modifying therapies and other neuroprotective compounds for HAND.

Contact: 443-799-7241

Not currently enrolling; future enrollment planned for 2017


Request an Appointment

Maryland Patients

To learn more about the Johns Hopkins NIMH Center, please call 443-287-0571.
Contact Us

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337

 

Traveling for Care?

Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Outside of Maryland (toll free)
410-464-6713

Request an Appointment
Medical Concierge Services

International Patients
+1-410-502-7683

Request an Appointment
Medical Concierge Services

 
blue suitcase