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ALS Clinical Trials

What is a Clinical Trial?

A clinical trial is a method for medical researchers to study, test and discover effective treatments. Clinical trial research studies can occur in a lab or involve human beings.

Study Title: NA_00017913 A multicenter study for the validation of ALS biomarkers

Summary: This research collects and compares blood and cerebrospinal fluid (CSF) samples from people with and without amyotrophic lateral sclerosis (ALS).  We hope to learn more about the underlying cause of ALS and find unique biological markers (biomarkers) that could be used to develop new therapies.

Lab Study

Recruiting Status: Enrollment is closed


Study Title: NA_00033726 Generation and characterization of cell lines for amyotrophic lateral sclerosis

Summary: This research is designed to augment the understanding of amyotrophic lateral sclerosis (ALS) by looking at skin cells from people with genetically confirmed familial ALS, as well as those from healthy individuals. Once the skin cells have been grown in the laboratory, they will be used to generate induced pluripotent stem cells, which will be made into nerve cells. Scientists will then be able to study these cells to learn more about ALS and potential treatments.

Lab Study

Recruiting Status: Enrollment is closed


Study Title: NA_00021979 Skin biopsies to generate cells lines for study of amyotrophic lateral sclerosis

Summary: This research is designed to augment the understanding of amyotrophic lateral sclerosis (ALS) by looking at skin cells from people with sporadic ALS and similar neuromuscular diseases, as well as those from healthy individuals. Once the skin cells have been grown in the laboratory, they will be used to generate induced pluripotent stem cells, which will be made into nerve cells. Scientists will then be able to study these cells to learn more about ALS and potential treatments.

Lab Study

Recruiting Status: Actively enrolling


Study Title: NA_00022650: Trial of resistance and endurance exercise in amyotrophic lateral sclerosis

Summary: A study to see whether one type of exercise is tolerated better and is safer than another type for people with ALS. The study will also collect information on how the body responds to exercise in people with ALS.

Each participant will be randomly assigned to one of three types of exercise: weight lifting (resistance exercise), stationary bicycling (endurance exercise), and range-of-motion stretching exercise (the current standard of care for ALS patients).

Human Study

Recruiting Status: Actively enrolling


Study Title: NA_00075815: A phase IIb, multi-national, double-blind, randomized, placebo-controlled study to evaluate the safety, tolerability and efficacy of CK-2017357 in patients with amyotrophic lateral sclerosis (ALS)

Summary: The Cytokinetics company is investigating tirasemtiv as a potential new therapy for the temporary improvement of muscle weakness and muscle fatigue in patients with ALS. Study subjects will receive three months of daily dosing with this compound. The primary goal of this study is to determine if the drug is safe and tolerable in ALS patients. It also hopes to assess the effect of this compound on functional status and muscle strength in ALS patients.
 

Human Study

Recruiting Status: Enrollment complete


Study Title: NA_00080565:Imaging myelin injury in amyotrophic lateral sclerosis (ALS)

Summary: This study will see if Magnetic Resonance Imaging (MRI) is useful in determining which parts of the brain are affected in amyotrophic lateral sclerosis (ALS) and assess if any changes in the MRI can predict the changes in disability of ALS patients at six-month intervals.
 

Human Study

Recruiting Status: Actively enrolling


Study Title: NA_00073452: Metabotropic glutamate receptor 5 (mGluR5) imaging in amyotrophic lateral sclerosis (ALS) patients and healthy volunteers

Summary: This study will use PET scanning and the compound [18F]FPEB to look at and compare certain areas of the brain and the upper spinal cords of people with and without ALS. A PET scan measures the radioactivity of drug given into a vein and uses this information to make a picture of how the brain works. [18F]FPEB may help doctors make images of the brain to help diagnose and treat people with ALS.Twenty patients with ALS will be enrolled, with each undergoing one MRI scan and one PET scan. Subjects completing both scans will receive $300 compensation.

Human Study

Recruiting Status: Actively enrolling


Study Title: NA_00081975: Environmental exposure to toxins in patients with amyotrophic lateral sclerosis (ALS)

Summary: This research seeks to determine if a link exists between exposure to certain environmental toxins and development of ALS. The researchers will collects information about patients’ health, military service, occupation and recreational activity to better understand how we might be able to prevent or reduce the risk of certain diseases.

Human Study

Recruiting Status: Actively enrolling

 
 
 
 
 
 

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