Jeffrey D. Rothstein, M.D., Ph.D., Investigator
Dr. Rothstein is Professor of Neurology and Neuroscience and a faculty member of the Graduate Program in Cellular and Molecular Medicine at Johns Hopkins. He is the Founder and Director of the Robert Packard Center for ALS Research at Johns Hopkins. This is a multi-institutional, multi-national collaborative academic organization devoted toward understanding the cause of ALS and translating the information into new therapies. He is also the Director of the Brain Science Institute and directs the Brian Science Institute Neurotranslation program. He is also the Co-Director of the ALS Clinic.
His basic science laboratory interests include:
- regulation of astroglial glutamate and lactate transporter by protein-protein interactions, epigenetic, microRNA and genomic processing
- role of glutamate and lactate transporter regulation in abnormal synaptic transmission and neurodegeneration
- the biology of astroglial in neurodegenerative disease
- various molecular mechanisms of selective neurodegeneration in motor neuron disease
- identification drugs and non-chemical means to modulate glutamate transporters and lactate transporters as therapeutics
- the cloning and characterization of novel proteins which may be responsible for the cellular regulation of all glutamate transporter subtypes
- role of astrocytes and membrane transporters in normal and abnormal synaptic transmission.
Dr. Rothstein's Recent Research
- Human nasal olfactory epithelium as a dynamic marker for CNS therapy development
- A Hexanucleotide Repeat Expansion in C9ORF72 is the Cause of Chromosome 9p21-Linked ALS-FTD
- NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration