Ahmet Hoke, M.D., Ph.D., Investigator
Dr. Hoke is a Professor of Neurology and Neuroscience at Johns Hopkins and Director of the Division of Neuromuscular Diseases. He focuses on neuromuscular diseases with a particular interest in peripheral nerve diseases. He has specialized expertise in nerve conduction studies, electromyography and nerve and muscle biopsy reading. In 2005, he received the coveted Derek Denny Brown Young Neurological Scholar Award given by the American Neurological Association to a member of the association who has achieved a significant stature in neurological research and whose promise of continuing major contributions to the field of neurology is anticipated.
Dr. Hoke's research interest includes studies on basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. He uses in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies and toxic neuropathies) to study the mechanism of axonal damage and develop therapeutic targets for drug development. In addition, he has more basic research focusing on mechanisms of axonal degeneration and regeneration using in vitro and in vivo models. He utilizes engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen in many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.
Dr. Hoke’s Recent Research
- A (Heat) Shock to The System Promotes Peripheral Nerve Regeneration
- Nitric Oxide Prevents Axonal Degeneration by Inducing Hif-1–Dependent Expression of Erythropoietin
- Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons