Already known to cut proteins, the enzyme SPPL3 turns out to have additional talents, according to a new study from Johns Hopkins. In its newly discovered role, SPPL3 works without cutting proteins to activate T cells, the immune system’s foot soldiers. Because its structure is similar to that of presenilin enzymes, which have been implicated in Alzheimer’s disease, the researchers believe their findings could shed more light on presenilin functions, in addition to providing new insight into how the immune system is controlled.
A Blood Pressure Hormone Implicated in Psychosis; Nutrient Deficiency Linked to Brain Wasting in Huntington’s Disease; Autistic Mice Become Social with Drug Treatment
A multicenter team of researchers has identified an enzyme key to the survival and spread of glioblastoma cancer cells that is not present in healthy brain cells, making the enzyme a promising therapeutic target.
Recent research from The Johns Hopkins University suggests that in high stakes situations, a person's performance depends on two factors: the framing of the incentive in terms of a loss or a gain, and their fear of loss.
Neuroimaging scientists at The Johns Hopkins University and the University of Copenhagen are leading a team that received a $1.5 million grant from the Obama administration’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to create a next-generation brain imaging system. They hope to help unlock the secrets of mental illnesses, including dementia, Parkinson's disease, depression and schizophrenia. The National Institutes of Health announced the award on Sept. 30.