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RLS Research and Clinical Trials

Every day, research uncovers new information about possible therapies for RLS. Your involvement in clinical studies could help in the development of medications to treat RLS. You, a family member, and many other people may benefit from your willingness to become involved.

What is a Clinical Study?

A clinical study is carefully designed to test the effects of a medication, medical treatment, or device in a group of volunteers. Clinical studies are an important step in making new medication available. They measure the study drug's ability to treat a condition, its safety, and its possible side effects. This information helps doctors and the Food and Drug Administration (FDA) decide if a drug is safe and effective for an illness or disease before it is made widely available to physicians and patients.

During an individual's participation in a clinical study, he or she will see doctors and nurses frequently. In many clinical studies, participants may receive either the drug being studied or a placebo (sugar pill). Study related physical examinations, laboratory tests, and study medications are usually provided at no cost throughout the trial. In addition, travel and other expenses accrued during the study may also be reimbursed.

We are currently enrolling for the following Clinical Research Studies:

Glutamate, hyperarousal and restless legs syndrome.

  • Enrollment starts September 1, 2012 and stops August 31, 2015
  • This is a National Institute of Health Grant (NS075184)
  • This study will assess brain chemistry using special MR brain imaging and transcranial magnet stimulation in subjects with RLS compared to subjects without RLS
  • The duration of subject involvement in the study is about 2 weeks

In order to determine how chemicals in the brain of RLS subjects are different, we need to compare those results to results found in subjects who do not have RLS.  Those without RLS are referred to as “control” subjects.

We are in need of healthy Sleepers who DO NOT have RLS symptoms and who are 45 years or older to participate in this study as a “control” subject.

Interested participants should call the RLS Center Study Recruiter at 410-550-1046

Request an Appointment

Maryland Patients

To make an appointment with one of our Restless Legs Syndrome physician specialists, please call  410-550-0571.
Request an Appointment

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337



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