Skip Navigation
Search Menu
Neurology and Neurosurgery

In This Section      
Print This Page

Understanding How Myelin Protects Axons

Myelin is wrapped around axons (nerves) and serves to protect the nerves and to enhance nerve transmission. Myelin, as well as the underlying axon, is a target of damage in MS. Myelin is made up of fats and proteins. We continue to study how a myelin protein, called MAG, and a newly identified cousin, called Netrin, can communicate with the axon (nerve fiber) and protect it from damage (Nguyen et al J. Neuroscience, 2009). 

Understanding how myelin protects axons could lead to novel ways of protecting or repairing nerves without necessarily having to make new myelin.  This research is now unraveling the molecular details of how this crosstalk between MAG and axons occurs. Collaborators in this work include Dr. Peter Calabresi.

MAG prevenst axonal degeneration

MAG (top row) prevents axonal degeneration that ensues overtime as seen in the control (lower row).

Request an Appointment

Maryland Patients

Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259

Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337

 

Traveling for Care?

Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Outside of Maryland (toll free)
410-464-6713

Request an Appointment
Medical Concierge Services

International Patients
+1-410-502-7683

Request an Appointment
Medical Concierge Services

 
blue suitcase