The Neurosurgery Pain Research Grant Fund has been established to support members of the Johns Hopkins neurosurgery faculty in their research to better understand, treat and prevent pain by the provision of one year grants. Award recipients and a summary of their respective studies are:
Basic and Clinical Studies of Cortical Stimulation Sites for Treatment of Pain
Studies the potential of transcranial magnetic stimulation (TMS) as an efficacious treatment for acute pain, such as post-operative pain.
Contribution of Different Sodium Channel Isoforms to Excitability and Conduction in Nociceptive Primary Afferent Neurons of Non-human Primates
Examine NaV channel isoforms expressed along the neuronal membrane of nociceptive neurons to further development of improved strategies for treating pain in humans.
William Stanley Anderson
Active Modeling of Spinal Cord Stimulation
Provide quantitative information on spinal cord stimulation effects on spatiotemporal properties of dorsal column activity, and to identify efficacious alterations.
Inhibition of Pain in a Model of Human Metastatic Breast Cancer to the Spine
Develop drug-releasing constructs that may be rapidly translated to clinical medicine for patients suffering from painful metastatic spine disease.
Vertebral Body Reduction Instrument for Low Back and Radicular Pain Treatment
Test and further refine the Vertebral Body Reduction Instrument and to translate it to the clinical setting for helping patients with back pain.
Pain Related Genes in Schwannomatosis
Identify and characterize genes and proteins involved in schwannoma related pain, providing directions for developing new methods of pain treatment.
Cortical Stimulation Sites and Pain Treatment Study
Examine the possibility that trans cranial magnetic stimulation (TMS) could be effective for the treatment of acute pain, such as post-operative pain
William Stanley Anderson
Spasticity and Pain Study
Determination of the incidence and characteristics of spasticity after spinal cord injury
Lumbar Spinal Fusion and Pain Study
Use the rabbit model to investigate long-term pain control after lumbar spinal fusion
Vertebral Body Reduction Instrument Study
Use the vertebral body reduction instrument for low back and radicular pain treatment
Schwannomatosis Gene and Pain Study
Identification of pain related genes in schwannomatosis patients
Metastatic Bone Pain Study
Bisphosphonate-releasing porous polymethylmethacrylate/gelatin constructs for reducing metastatic bone pain
Metastatic Spine Lesions and Pain Study
Determine the mechanism and effector cell populations involved in the antitumor response generated by the combination of stereotactic radiosurgery and anti-PD-1 antibody
Develop models to improve radiofrequency thermocoagulaton
Post Hemorrhage Hydrocephalus and Pain Study
Reducing chronic shunt dependence in pediatric post-hemorrhagic hydrocephalus
Headache Pain Study
Headache pain control for patients presenting with intracranial tumors
Anatomical Studies of the Human Skull Base
Endoscopic and high resolution imaging of human skull base anatomy to serve as a reference and surgical guide to begin to offer more and more less invasive surgical procedures to patients to reduce post-operative pain
Low Grade Subarachnoid Hemorrhage Pain Management Study
A randomized controlled study to evaluate the efficacy of a defined regimen of pain relief using patient controlled analgesia (PCA) for headache management in non-traumatic SAH
Seeing Pain More Clearly
Functional and molecular characterization of nociceptor subtypes in non-human primates