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Research Areas

Dr. Marek Mirski
Dr. Mirski’s current laboratory research involves the investigation of the subcortical mechanisms of seizure propagation and cortical synchrony. Major efforts are directed toward the development of methodologies for seizure inhibition via site-specific subcortical electrical stimulation. The principal finding of his research - identification of synaptically linked subcortical elements important in seizure propagation - has led to current FDA sanctioned Phase II-III clinical trials of targeted thalamic stimulation in patients with intractable seizures. Dr. Mirski also has primary research in the treatment of brain edema, ICU sedation, and acute stroke.

Dr. Romergryko Geocadin
Dr. Geocadin’s research interests include basic, translational and clinical investigations in acute neurological injuries after global cerebral ischemia (brain injury and cardiac arrest); neurologic injury mechanisms related leading coma, therapeutic hypothermia for acute neurologic injuries; novel application of neuro-electrophysiology for early detection of acute neurological injuries and. He is currently leading an NIH sponsored multicenter study investigating the role of early QEEG in determining functional outcome in cardiac survivors. His other areas of interest include coma, encephalitis, cerebral herniation, seizures and intracranial hemorrhage.

Dr. J. Ricardo Carhuapoma
Dr. Carhuapoma's current research interests include the different hemodynamic and metabolic aspects of cerebral blood flow under physiologic conditions and after acute brain injury as well as their significance in neurologic outcome, the use of MRI techniques in the study and understanding of ongoing neuronal damage after brain injury to design and assess therapies used in neurologic critical care, and the natural history and impact on neurological outcome of perihematoma brain edema following ICH.

Dr. Wendy Ziai
Dr. Ziai’s research interests include platelet dysfunction in intracerebral hemorrhage, intraventricular rt-PA for intraventricular hemorrhage, and markers of vasospasm in subarachnoid hemorrhage. She is also involved in research to developing ways to control infections in the hospital setting.

Dr. Robert Stevens
Dr. Stevens’ research includes the evidence-based management of aneurysmal subarachnoid hemorrhage, organ failure in cerebrovascular disease, encephalopathy and cognitive dysfunction in critical illness, critical illness neuromuscular syndromes, and the diagnosis and management of coma.

Dr. Paul Nyquist
Dr. Nyquist’s research goal is to bridge the gap between clinical trials and benchtop innovations. He has embraced a research strategy characterized by two features. The first is an ongoing interest in any translational research projects that incorporate well founded biological models into patient care in brain injury. He has a theoretical focus which emphasizes the role of inflammation in cerebrovascular disease with particular attention to the effects of inflammation on endothelial activation. His goal is to develop acute interventions that will improve outcomes in patients with acute brain injury of any type.

Dr. Neeraj S. Naval
Dr. Naval's current clinical research interests include studying the possible role of neuroprotective and anti-inflammatory agents in the setting of spontaneous intracerebral hemorrhage, assessing the role of statins in edema amelioration, and analyzing the impact of critical care on outcomes following intracranial hemorrhage.

Dr. Matthew A. Koenig
Dr. Koenig’s research activities include translational, benchtop, and clinical investigations focused on the neurological consequences of cardiac arrest and resuscitation. In close collaboration with Drs. Romergryko Geocadin and Daniel Hanley in the Department of Neurology and Professor Nitish Thakor in the Department of Biomedical Engineering, he has focused on identifying electrophysiological markers of neurological recovery and coma emergence after global cerebral ischemia. Other research interests include the use of hypertonic solutions for reversal of transtentorial herniation, predicting the development of malignant cerebral edema after stroke using transcranial Doppler ultrasonography, and investigating the role of statin use as a neuroprotective agent in cardiac surgery.

Dr. Bradford D. Winters
Dr. Winters’ research interests have ranged from his background in microbiology where his doctorate thesis examined the molecular pathogenesis of S. pyogenes to several years of vascular biology research examining the relationships between obesity and vasomotor tone to his current interests in patient safety and quality of care research. Some of the projects he is currently working on include developing measures for rapid response systems outcomes, developing guidelines for policy development for patient safety initiatives, and pain management in post-craniotomy patients.

Dr. Geoffrey Ling
Dr. Ling’s research interests focus on brain and spinal cord injury.

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