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Clinical Trials

Study Name: Silent Stroke and Inflammation in a Population of Patients at Risk for Cerebrovascular Disease
Principal Investigator: Paul Nyquist
Johns Hopkins Site PI: Paul Nyquist
Coordinating Center: Johns Hopkins, "Siblings and Heart"
Research Plan: This is a concurrent cohort study of an ongoing prospective epidemiological study looking at the relationship between genes and small vessel ischemic disease in a population genetically enriched for risk factors for coronary artery disease.
Target Enrollment: 1000
Number of Study Sites: 1
Start Date: Jan 2005
Anticipated Stop Date: Indefinite
Funding Source: GCRC

Study Name: Biomarkers and Subarachnoid Hemorrhage
Principal Investigator: Paul Nyquist
Johns Hopkins Site PI: Paul Nyquist
Coordinating Center: Johns Hopkins
Research Plan: This is an ongoing prospective study of subarachnoid hemorrhage. We are banking serum and CSF. We are examining inflammatory mediators that influence the development of subarachnoid hemorrhage using a variety of proteomic platforms such as SELDI, a variety of protein based chips, as well as mass spect.
Target Enrollment: 300
Number of Study Sites: 1
Start Date: Jan 2005
Anticipated Stop Date: Indefinite
Funding Source: Internal funding

Study Name: Nitric Oxide Metabolism in the Cerebrospinal Fluid of Patient's with Subarachnoid Hemorrhage
Principal Investigator: Paul Nyquist
Johns Hopkins Site PI: Paul Nyquist
Coordinating Center: Johns Hopkins
Research Plan: This is an ongoing prospective study of patients with Subarachnoid Hemorrhage; we are analyzing CSF for the metabolites of nitric oxide metabolism as a pilot study to look at differences in the concentration of these metabolites in relation to different out comes such as vasospasm.
Target Enrollment: 500
Number of Study Sites: 1
Start Date: Jan 2006
Anticipated Stop Date: Indefinite
Funding Source: Internal funding

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