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Specialty Clinic for Diseases of Complement Dysregulation and Thrombotic Microangiopathies

(Includes Atypical HUS, TTP, C3 glomerulopathy, Dense Deposit Disease)

 

Physician within the Division of Nephrology who offers expert care in these areas

C. John Sperati, MD, MHS
Director, Specialty Clinic for Diseases of Complement Dysregulation and
Thrombotic Microangiopathies
Assistant Professor of Medicine
Johns Hopkins University School of Medicine

Our Location

 The Johns Hopkins Outpatient Center
 601 N. Caroline St., 7th Floor
 Baltimore, Maryland 21287

Request an Appointment
  Call 443-287-6182

 

Thrombotic Microangiopathy

Thrombotic microangiopathies (TMA) are clinical syndromes defined by the presence of hemolytic anemia (destruction of red blood cells), low platelets, and organ damage due to the formation of microscopic blood clots in capillaries and small arteries. The kidneys are commonly affected, although virtually any organ may be involved. Smoldering TMA will sometimes result in kidney damage without significant anemia or low platelets. Under the microscope, the blood demonstrates injured red blood cells known as schistocytes or fragments. Kidney disease can be severe, with over 50% of individuals requiring dialysis with a cause of TMA known as atypical hemolytic uremic syndrome (aHUS). Historically, TMA were often referred to as TTP/HUS, or thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. It is now recognized that a large number of different diseases can result in TMA. Read more...  

 

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Maryland Patients

410-464-6713

 

Traveling for Care?

Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Outside of Maryland (toll free)
410-955-0670

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Medical Concierge Services

International Patients
+1-410-502-7683

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