Research activity in the Department of Molecular and Comparative Pathobiology is robust and interactive within and beyond our department. Faculty conduct research in animal models of AIDS, cancer, degenerative CNS disease, cardiovascular disease, developmental biology, rickettsial, parasitic and infectious diseases. Our department has an excellent research infrastructure with state-of-the-art laboratories in the Edward D. Miller Research Building with Biohazard Level 3 laboratories for studies of infectious diseases including HIV and SIV. A major research focus in the Retrovirus Laboratory is the study of molecular virology of HIV, SIV and other lentiviruses, as well as pathogenesis of these viruses in animal model systems. The Retrovirus Laboratory holds a grant for training both pre- and post-doctoral students in the molecular pathogenesis of lentiviral diseases.
The Phenotyping Core, led by Dr Cory Brayton, coordinates testing and phenotyping of genetically engineered mice and other models that can include imaging, behavioral, metabolic, pathology and clinical analyses.
MCP faculty, fellows, and residents facilitate identification, and resolution of naturally occurring disease outbreaks in the institutional animal colonies through Comparative Pathology, and provide clinical care of research animals through Research Animal Resources.
With its strong emphasis on animal models of human disease, solid funding base and long history of producing leaders in academic and industrial settings, Molecular and Comparative Pathobiology is a national leader in research on animal diseases and animal models of human diseases.
The department obtained one of the first NIH training grants for postgraduate training of D.V.M./V.M.D. veterinary scientists and has been funded continuously for over 35 years. More than 100 veterinarians have trained here. Many have become department chairs and leaders in academia and industry throughout the U.S., Canada and Europe. For more information on combined clinical/research postdoctoral training and clinical residency training, please contact Nancy Nath. In addition to mentoring in the department's training program, and teaching in medical school and graduate school courses, MCP faculty direct and organize courses in the School of Medicine (SOM) and in the School of Public Health (SPH) that are relevant to translational biomedical science and research. MCP COURSE LISTING
Cardiovascular Disease and Pharmacogenomics
Polina Sysa, M.D.
Xu Yi, M.D.
Dara Kraitchman, V.M.D, Ph.D., F.A.C.C.
Genetically Engineered Mice
(Molecular Mechanisms of Disease)
Mechanism Based Therapies and Stem Cell Pathobiology