Diana Scorpio, DVM, MPH, DACLAM

M.P.H. The Johns Hopkins Bloomberg School of Public Health, May 2004.
D.V.M.  Michigan State University, Doctor of Veterinary Medicine, May 1997.
B.S.      University of Rhode Island, Animal Science and Technology, May 1993.

Assistant Professor, Dept Molecular and Comparative Pathobiology and Clinical Veterinarian, Research Animal Resources.  Faculty appointment with clinical, research, teaching, and administrative responsibilities. Clinical duties focus primarily on the preventative health and management of large animal species (NHP, dogs, cats, swine, etc.), as well as peri-operative and post-operative management of surgical models.  Also responsible for teaching and mentoring of laboratory animal and pathology fellows. Member of the IACUC, with training and teaching responsibilities.

Research Focus
Tick-borne bacterial infections, specifically Anaplasma and Ehrlichia species, animal model development of human and animal rickettsial disease and microbial pathogenesis.

Publications:

Choi KS, Scorpio DG, Dumler JS.  (2004)   Anaplasma phagocytophilum ligation to toll-like receptor (TLR) 2, but not to TLR4, activates macrophages for nuclear factor-kappa B nuclear translocation.  Journal of Infectious Diseases.  189:1921-1925.

Headley SA, Vidotto O, Scorpio DG, Dumler JS, Mankowski J.  (2004)  Suspected cases of Neorickettsia-like organisms in Brazilian dogs.  Annals New York Academy of Sciences 1026:79-83.

Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS.   (2004)  CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse HGA model.  Clinical and Diagnostic Laboratory Immunology 11:963-968.

Scorpio DG, Caspersen K, Ogata H, Park JH, Dumler JS.  (2004)  Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum.  BMC Microbiology 4:1 (on-line).

von Loewenich FD, Scorpio DG, Reischl U, Dumler JS, Bogdan C. (2004)  Control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, toll-like receptor (TLR) 2 and 4, or the TLR adaptor molecule MyD88. European Journal of Immunology 34:1789-1797.

Halasz CLG, Niedt GW, Kurtz CP, Scorpio DG, Bakken JS, Dumler JS.  (2005)  A case of Sweet syndrome associated with human granulocytic anaplasmosis.  Archives Dermatology 141:887-889.

Jagannath SB, Kantsevoy SV, Vaughn CA, Chung SS, Cotton PB, Gostout CJ, Hawes RH, Pasricha PJ, Scorpio DG, Magee CA, Pipitone LJ, Kalloo AN.  (2005)  Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model.  Gastrointestinal Endoscopy 61:449-453.

Scorpio DG, von Loewenich FD, Bogdan C, Dumler JS. (2005) Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load.  Annals New York Academy Science 1063:425-428.

Browning M, Garyu J, Dumler JS, Scorpio DG.  (2006)  Role of reactive nitrogen species on development of hepatic injury in a C57BL/6 model of human granulocytic anaplasmosis.  Comparative Medicine 56:55-62.

Headley SA, Scorpio DG, Barat NC, Vidotto O, Dumler JS.  (2006)  Neorickettsia helminthoeca in a Brazilian dog.  Emerging Infectious Diseases 12:1303-1304.

Scorpio DG, von Loewenich FD, Göbel H, Bogdan C, Dumler JS.  (2006) Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury.  Clinical Vaccine Immunology 13:806-809.

Choi KS, Webb T, Oelke M, Scorpio DG, Dumler JS. (2007) Differential innate immune cell activation and proinflammatory response in A. phagocytophilum infection. Infection and Immunity, in press.

Choi KS, Scorpio DG, Barat NC, Dumler JS. (2007) Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-? production. FEMS Immunology and Medical Microbiology 49:374-386.

Scorpio DG, Ruben DS, Liao Z, Hildreth JE, Fletcher CA.  (2008)  Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies.  Journal Medical Primatology 265, in press.

Scorpio DG, Leutenegger C, Berger J, Barat NC, Madigan JE, Dumler JS.  (2008)  Sequential analysis of A. phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosis.  Clinical Vaccine Immunology, in press.