Instructor of Comparative Medicine
Email: cfletch@jhmi.edu
Office: (410) 955-9770
Education and Training:
1995 B.S., North Carolina A&T State University
1999 D.V.M., University of Florida
2005 Postdoctoral Fellow in Laboratory Animal Medicine, Dept. of Comparative Medicine, Johns Hopkins School of Medicine
2005 PhD Johns Hopkins School of Medicine
Background and Training:
Dr. Fletcher received his DVM from the University of Florida in 1999. He earned a PhD in Pathobiology with a focus on viral immunology and HIV pathogenesis from the Department of Pathology with James Hildreth. Dr. Fletcher is a laboratory animal medicine veterinarian with a diverse background encompassing both clinical and research facets of comparative biology.
Research Focus:
Dr. Fletcher’s interests are defining the mechanisms involved in mediating vascular inflammation in coronary artery disease and HIV infection. Research in the Retrovirus Laboratory focuses on the immunopathogenesis of simian immunodeficiency virus (SIV) infection as a model of HIV encephalitis and cardiac dysfunction. In addition, further studies with Charles Lowenstein in the Department of Medicine explore the role of human immunodeficiency virus (HIV) and chemokines in vascular inflammation and thrombosis.
Research Activities:
Fletcher CA, Liao Z, Mason EN, Morrell CN, Lowenstein CJ, Platelet Factor 4 Activates Vascular Inflammation by Triggering Endothelial Exocytosis, Journal of Experimental Medicine, Jan 2006 (Submitted)
Fletcher CA, Liao Z, Adams RJ, and Hildreth JE, Characterization of an Anti-Lymphocyte Function-Associated Antigen-1 Antibody in Simian Immunodeficiency Virus (SIV)/Pigtail Macaque Model, Comparative Medicine, Feb 2006
Fletcher CA, and Hildreth JEK, “Inhibition of LFA-1 in Prevention of HIV Transmission”, Johns Hopkins University, Department of Comparative Medicine Year in Review Research Symposium, March, 2005
Fletcher CA, Cimakasky L, and Hildreth JEK, Lovastatin inhibits HIV-1 Infection: A novel investigative tool to study LFA-1 role in HIV pathogenesis, abstract accepted at Keystone Symposia- HIV Pathogenesis meeting, April, 2004
Fletcher CA, Mouse Phenotyping: A Step by Step Guide, presented at the Johns Hopkins University Animal Care and Use Committee Seminar Series, 2004
Fletcher CA and Hildreth J.E.K., The Role of Lipid Rafts and Integrins in HIV Infection, Department of Pathology, Johns Hopkins School of Medicine Grand Rounds,2004
