Associate Professor of Molecular and Comparative Pathobiology
Director, Phenotyping Core
Email: cbrayton@jhmi.edu
Phone: 410 502 3050
Background and Training
1981 B.A. Williams College
1985 D.V.M. Cornell University
1997 Diplomate, American College of Laboratory Animal Medicine
1997 Diplomate, American College of Veterinary Pathologists
Dr. Brayton received her D.V.M. from Cornell University, and did postdoctoral research and pathology training in New York City at the Animal Medical Center, Cornell University and The Rockefeller University. At The Rockefeller University (1989-1992), she became specifically interested in the pathology and characterization (phenotyping) of genetically engineered mice (GEM), and continued to pursue this interest at several institutions while heading the Facility for Comparative Studies at the Hospital for Special Surgery (1992-1998). At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, and was responsible for health surveillance and diagnostic pathology for a diverse research population including more than 150,000 mice. She also was associate professor in pathology, associate director of the Center for Comparative Medicine, interim attending veterinarian, and served on the IACUC , while pursuing research collaborations, teaching initiatives, and developing national and international conferences on the characterization and pathology of genetically engineered mice.
In 2004 she moved to Johns Hopkins to develop a collaborative phenotyping core based in the Department of Molecular and Comparative Pathobiology (MCP), where veterinarian faculty investigators and trainees provide a unique comparative and translational research resource, in an institution with exceptional resources for multidiscipinary biomedical research.
Currrent Roles
The Phenotyping Core aims to assist in phenotyping genetically engineered animals, and to facilitate interdisciplinary collaborations. As director of this collaborative core effort, Dr. Brayton has reached out to JHU faculty investigators who wish to participate in multidisciplinary phenotyping and translational research initiatives, and additional participants are always welcome. We organized a JHU Phenotyping Symposium 2006, 2007, 2008, and a new phenotyping course (2007, 2008) that emphasize JHU resources and faculty. She has developed a website, a newsletter, a monthly comparative pathology and phenotyping slide conference. She has become involved in national and international phenotyping initiatives, conferences and workshops to promote understanding of mouse biology, pathology and phenotyping.
Learn more about the Phenotyping Core .
Contact me with specific questions, or to participate in the core.
Research
Dr. Brayton’s primary research interest is in collaborating as a pathologist in phenotyping and other translational research initiatives. Whether caused primarily by intended genetic manipulations, spontaneous mutations, experimental compounds, infections or other intended manipulations, phenotypes also are impacted by nature and nurture influences. Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as the impact of infectious and other environmental factors on pathology and other phenotypes. She has published on comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and infectious diseases, in mice and other species.
Contact me to discuss phenotyping, collaboration or research pathology needs.
Teaching
Dr. Brayton’s primary teaching interest is to enhance and promote understanding of model organism biology and pathology, especially as it is relevant to phenotyping and experimental design for translational research. She has developed, directed, co-directed, and lectured in symposia, conferences, courses and workshops, relevant to phenotyping, pathology, genetics of mice and other laboratory animals, in the US and abroad. She has authored and coauthored books, chapters and invited reviews on mouse biology and pathology. At JHU, she developed the JHU Phenotyping Symposium 2006, 2007, 2008, and developed a new course (680.712) in the graduate school Phenotyping for Functional Genetics . She also participates as faculty and lecturer in 680.701 Principles of Animal Pathology & Genetically Engineered Mice; 680.702 LAM/PATH Integrated Problem Solving; 680.711 Comparative Pathology Conference; Toxicological Pathology, Bloomberg School of Public Health.
Selected References
Brayton C. 2006 Spontaneous diseases in commonly used inbred mouse strains. Chapter 25. Pp 623-717. In Fox. J.G. & al. Ed’s. In THE MOUSE IN BIOMEDICAL RESEARCH 2nd Ed. Vol 3. ACLAM series. Elsevier.
Brayton C, Nicklas W, Mahler M. 2005. Viral Infections. In Hedrich H. Ed. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES: THE LABORATORY MOUSE. Academic Press.
Suckow MA, Danneman PJ, Brayton CF. 2001. THE LABORATORY MOUSE. CRC Press.
Reece JJ, Siracusa MC, Southard TL, Brayton CF, Urban JF Jr, Scott AL. 2008. "Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung." Infect. Immun. 76(8): 3511-3524.
Valli T, Barthold SW, Ward JE, Brayton C, Nikitin A, Borowsky AD, Bronson RT, Cardiff RD, Sundberg J, Ince T. 2007. Over 60% of NIH extramural funding involves animal-related research. Vet Pathol. 2007 Nov;44(6):962-3
Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. 2007. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci. 2007 Oct 3;27(40):10849-59.
Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. 2007. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem. 2007 Nov 2;282(44):32264-73.
Iskander K, Gaikwad A, Paquet M, Long DJ 2nd, Brayton C, Barrios R, Jaiswal AK. 2005. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. Mar 15;65(6):2054-8.
Kurtzman CP, Robnett CJ, Ward JM, Brayton C, Gorelick P, Walsh TJ. 2005. Multigene phylogenetic analysis of pathogenic candida species in the Kazachstania (Arxiozyma) telluris complex and description of their ascosporic states as Kazachstania bovina sp. nov., K. heterogenica sp. nov., K. pintolopesii sp. nov., and K. slooffiae sp. nov. J Clin Microbiol. 43(1):101-11.
Vilchez RA, Brayton CF, Wong C, Zanwar P, Killen DE, Jorgensen JL, Butel JS. 2004. Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters. Virology. 330(1):168-77.
Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. 2003. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 71(10):5986-93.
Kogan S; Ward J; Anver M; Berman J; Brayton C; Cardiff R; Carter J; de Coronado S; Downing J; Fredrickson, T; Haines D; Harris A; Harris N; Hiai H; Jaffe E; MacLennan I; Pandolfi P; Pattengale P; Perkins A; Simpson R; Tuttle M; Wong J; Morse H. 2002. Bethesda Proposals for Classification of Non-Lymphoid Hematopoietic Neoplasms in Mice. Blood. 100(1):238-45.
Kato M, Patel M, Levasseur R, Lobov I, Chang B, Glass D, Hartmann C, Li L, Hwang T, Brayton C, Lang R, Karsenty G, Chan L. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. Apr 15;157(2):303-14.
Choi J, Nannenga B, Demidov O, Bulavin D, Cooney A, Brayton C, Zhang Y, Mbawuike N, Bradley A, Appella E, Donehower L. 2002. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol Feb;22(4):1094-105
Tyner S., Choi J., Jones N, Lu X, Soron G, Cooper B, Brayton C, Karsenty G, Bradley A, Donehower, L. 2002. A germline p53 mutation associated with enhanced tumor resistance and altered longevity in mice. Nature 415, 45–53 (3 January 2002)
Prince J, Brayton C, Fossett M, Durand J, Kaplan S, Smith C, Ballantyne C. 2001. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J Immunol. 15;166(12):7362-9
Brayton CF, Justice MA, Montgomery CA. 2001. Evaluating Mutant Mice: Comparative Pathology. Veterinary Pathology. 38(1):1-19. Invited Review.
