Associate Professor, Molecular and Comparative Pathobiology
Email: cbrayton@jhmi.edu
Office: 410-502-3050 1977-1981 | BA Biology/Classics | Williams College; Williamstown, MA | | 1981-1985 | DVM | Cornell University, NYS College of Veterinary Medicine, Ithaca, NY | | 1985-1986 | Internship | The Animal Medical Center; New York, NY | | 1986-1989 | Postdoctoral fellowship | NIA, Aging Research; Cornell University Medical College and NYS College of Veterinary Medicine; New York, NY; Ithaca, NY | | 1989-1992 | Postdoctoral fellowship | NIH, Comparative Medicine/Pathology; The Rockefeller University Cornell University Medical College; Memorial Sloan Kettering Cancer Center, The Animal Medical Center; New York, NY |
1997 American College of Laboratory Animal Medicine
1997 American College of Veterinary Pathologists NY, MA, RI, TX
Texas
2004-current:
Johns Hopkins University School of Medicine, Baltimore, MD
Director, Phenotyping Core
Associate Professor, Molecular and Comparative Pathobiology 1998 – 2004:
Baylor College of Medicine, Houston, TX. (AAALAC 00876)
Head, Comparative Pathology Laboratory, Center for Comparative Medicine
Associate Professor, Pathology
Associate Director of Research, Center for Comparative Medicine
Attending Veterinarian, interim/acting 2003, 2004
Member, Institutional Animal Care and Use Committee 1997 – 1998:
IDEXX Veterinary Services, Totowa, NJ.
Consulting Pathologist 1992 – 1998:
Hospital for Special Surgery; New York City. (AAALAC 00175)
Director of Veterinary Services, and the Facility for Comparative Studies
Assistant Scientist in Pathology
Chair, Institutional Biosafety Committee for Research Involving Recombinant DNA
Member, Institutional Safety Committee
Member, Institutional Animal Care and Use Committee 1992 – 1998:
New York Blood Center; New York City. (AAALAC 00306)
Attending Veterinarian
Member, Institutional Animal Care and Use Committee
The post genomic era has arrived. The human genome is estimated to have approximately 50,000 functional genes. Functional genomics initiatives aim to discover what those genes do, often using the mouse as a primary tool. Genes are added to, deleted from or disrupted in the mouse genome to try to determine their functions. Research mouse populations are exploding worldwide. Institutions that had only a few thousand mice only a few years ago may have more than 100,000 mice today. Scientists who know everything about a gene and its product (a protein), or who know everything about its human disease implications, may have less expertise in the mouse or other biological system with which they find themselves working.
In addition to the intended genetic manipulations, genetically engineered mice (GEM) are products of their background genetics (nature), and of experiential and environmental influences (nurture). Impacts and interactions of all of these factors must be recognized to understand gene functions in the context of a whole organism in its environment. While mice are the current mammalian model of choice, other species have manipulable genomes and play important roles in functional genomics initiatives. In addition, spontaneous genetic defects in domestic and exotic species can be characterized more easily than ever and can provide useful models for some genetically determined conditions. Cory Brayton received her D.V.M. from Cornell University, and did postdoctoral training at the Animal Medical Center, Cornell University and The Rockefeller University in New York City. She had interests in research and pathology before entering veterinary school, and continued to develop and pursue these interests during and after veterinary clinical training at Cornell and the Animal Medical Center. During her postdoctoral training at The Rockefeller University (1989-1992), she became specifically interested in the pathology and characterization (phenotyping) of genetically engineered mice (GEM), and continued to pursue this interest at several institutions while heading the Facility for Comparative Studies at the Hospital for Special Surgery (1992-1998), and while preparing for specialty board certification in Veterinary Pathology (ACVP) and in Laboratory Animal Medicine (ACLAM), both of which she obtained in 1997. At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, which was responsible for health surveillance and diagnostic pathology for a large and diverse research population that included a transgenic mouse facility for more than 100,000 mice. She also was an associate professor in pathology, served as an IACUC member, associate director of the Center for Comparative Medicine, and interim attending veterinarian, while pursuing a variety of research collaborations, teaching initiatives, and developing three conferences on the characterization and pathology of genetically engineered mice. In 2004 she moved to Johns Hopkins to develop a collaborative phenotyping core based in the Department of Molecular and Comparative Pathobiology. Dr. Brayton’s primary goal is to promote functional genomics initiatives by assisting and collaborating in the characterization and use of genetically and phenotypically relevant models of gene function and disease, and to enhance understanding and expertise in phenotyping for functional genomics initiatives. Thus her research interests necessarily include the spontaneous pathology and genetics of research mice, as well as the impact of infectious and other environmental factors on pathology and other phenotypes. Other areas of interest include comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and a variety of infectious diseases. Dr. Brayton believes that a multidisciplinary approach of molecular and functional in vivo evaluations, as well as pathology, is critical to the accurate characterization (phenotyping) of genetically engineered animals and to the development of valid and relevant models from them. She and other faculty members, as well as post DVM residents and graduate students in the Department of Comparative Medicine, bring tremendous breadth and depth to Johns Hopkins phenotyping initiatives. Brayton, C.F. 1986. Dimethyl sulfoxide (DMSO): A review. Cornell Veterinarian. 76:61‑90. Lai, W.C.; Pakes, S.P.; Lu, Y.S.; Brayton, C.F. 1987. Mycoplasma pulmonis infection augments natural killer cell activity in mice. Laboratory Animal Science. June. pp. 299‑303 McCaffrey, T.A.; Falcone, D.J.; Brayton, C.F.; Agarwal, L.A.; Welt, F.P.; Weksler, B.B. 1989. Transforming growth factor beta activity is potentiated by heparin via dissociation of the transforming growth factor alpha‑2 macroglobulin inactive complex. J. Cell Biol. 109: 441‑448. McCaffrey, T.A.; Falcone, D.J.; Borth, W.; Brayton, C.F.; Weksler, B.B. 1992. Fucoidan is a non‑anticoagulant inhibitor of intimal hyperplasia. Biochem. Biophys. Res. Comm. 184 (2): 773‑781. Brayton, C.F. 1992. Amyloidosis, hemochromatosis and atherosclerosis in a roseate flamingo (Phoenicopterus ruber). Annals of the New York Academy of Sciences. (653):184‑190. Brayton, C.F. 1992. Wasting disease associated with cutaneous and renal nematodiasis in commercially obtained Xenopus laevis. Annals of the New York Academy of Sciences. (653): 197‑201. Brayton, C.F. 1992. Ask Arrowsmith. THE PHAROS. AOA. Spring 1992. p. 44. Camacho NP, Hou L, Toledano TR, Ilg WA, Brayton CF, Raggio CL, Root L, Boskey AL, The material basis for reduced mechanical properties in oim mice bones. J Bone Miner Res 1999 Feb;14(2):264-72 Camacho NP, Dow D, Toledano TR, Buckmeyer JK, Gertner JM, Brayton CF, Raggio, CL, Root L, Boskey AL. Identification of the oim mutation by dye terminator chemistry combined with automated direct DNA sequencing. J Orthop Res 1998 Jan;16(1):38-42 Brayton CF, Justice MA, Montgomery CA. 2001. Evaluating Mutant Mice: Comparative Pathology. Veterinary Pathology. 38(1):1-19. Invited Review Prince J, Brayton C, Fossett M, Durand J, Kaplan S, Smith C, Ballantyne C. 2001. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J Immunol. 15;166(12):7362-9 Tyner S., Choi J., Jones N, Lu X, Soron G, Cooper B, Brayton C, Karsenty G, Bradley A, Donehower, L. 2002. A germline p53 mutation associated with enhanced tumor resistance and altered longevity in mice. Nature 415, 45–53 (3 January 2002) Choi J, Nannenga B, Demidov O, Bulavin D, Cooney A, Brayton C, Zhang Y, Mbawuike N, Bradley A, Appella E, Donehower L. 2002. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol Feb;22(4):1094-105 Kato M, Patel M, Levasseur R, Lobov I, Chang B, Glass D, Hartmann C, Li L, Hwang T, Brayton C, Lang R, Karsenty G, Chan L. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. Apr 15;157(2):303-14. Gilbert BE, Seryshev A, Knight V, Brayton C. 2002. 9-nitrocamptothecin liposome aerosol: lack of subacute toxicity in dogs. Inhal Toxicol. 14(2):185-97. Kogan S; Ward J; Anver M; Berman J; Brayton C; Cardiff R; Carter J; de Coronado S; Downing J; Fredrickson, T; Haines D; Harris A; Harris N; Hiai H; Jaffe E; MacLennan I; Pandolfi P; Pattengale P; Perkins A; Simpson R; Tuttle M; Wong J; Morse H. 2002. Bethesda Proposals for Classification of Non-Lymphoid Hematopoietic Neoplasms in Mice. Blood. 100(1):238-45. Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. 2003. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 71(10):5986-93. Vilchez RA, Brayton CF, Wong C, Zanwar P, Killen DE, Jorgensen JL, Butel JS. 2004. Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters. Virology. 330(1):168-77. Iskander K, Paquet M, Brayton C, Jaiswal AK. 2004. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. Cancer Res. 64(17):5925-8. Kurtzman CP, Robnett CJ, Ward JM, Brayton C, Gorelick P, Walsh TJ. 2005. Multigene phylogenetic analysis of pathogenic candida species in the Kazachstania (Arxiozyma) telluris complex and description of their ascosporic states as Kazachstania bovina sp. nov., K. heterogenica sp. nov., K. pintolopesii sp. nov., and K. slooffiae sp. nov. J Clin Microbiol. 43(1):101-11. Iskander K, Gaikwad A, Paquet M, Long DJ 2nd, Brayton C, Barrios R, Jaiswal AK. 2005. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. Mar 15;65(6):2054-8. Brayton CF, Schwark W. 1995. Use and misuse of DMSO. In: CURRENT VETERINARY THERAPY XII. SMALL ANIMAL PRACTICE. Kirk, R.W. ed. W.B. Saunders Co. pp. 67-70. Suckow MA, Danneman PJ, Brayton CF. 2001. THE LABORATORY MOUSE. CRC Press Brayton C, Nicklas W, Mahler M. 2005. Viral Infections. In Hedrich H. Ed. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES: THE LABORATORY MOUSE. Academic Press. Brayton C Spontaneous diseases in commonly used inbred mouse strains. In Fox. J.G. & al. Ed’s. In THE MOUSE IN BIOMEDICAL RESEARCH 2nd Ed. ACLAM series. Elsevier. In Press. February 17-19, 2000 – Baylor College of Medicine, Houston TX – Pathology of Mutant Animal Models – Conference Developer, Director February 14-17, 2001 – Baylor College of Medicine, Houston TX – Pathology of Mutant Animal Models –Conference Developer, Director October 2001 C. L. Davis South Central Pathology Conference, Galveston TX Course Co-director February 12-16, 2002 – Baylor College of Medicine, Houston TX – Care and Characterization of Genetically Engineered Mice and Comparative Pathology in Functional Genomics Conference Developer, Director (NIH sponsorship) October 2002 C. L. Davis South Central Pathology Conference, Galveston TX Course Co-director March 31-April 4, 2003 – Pathology of Laboratory Animals; Nantes FR (EuroPOLA I) Course Co-director October 2-4, 2003 C. L. Davis South Central Pathology Conference, Galveston TX Course Co-director October 8-9, 2004 C. L. Davis South Central Pathology Conference, Galveston TX Course Co-director November 8, 2005 – AALAS National meeting, Nov 6-10, 2005. St. Louis, MO Seminar Leader: Practical Phenotyping; December 7, 2005 – ACVP National meeting, Dec 2-7, 2005. St. Louis, MO. Workshop Leader, Speaker: Pathology of genetically Engineered Mice March 22, 2006 – Johns Hopkins Phenotyping Symposium, Johns Hopkins University School of Medicine, Baltimore, MD; Conference Director/Organizer, Speaker May 15-19, 2006 – Pathology of Laboratory Animals; Nantes, France (EuroPOLA II) Course Co-director, Speaker February 17-19, 2000 – Baylor College of Medicine, Houston TX – Pathology of Mutant Animal Models – Conference Organizer, and speaker October 2000 C. L. Davis South Central Pathology Conference, Galveston TX – Course Co-director and Speaker: Hepatoblastoma in a transgenic mouse December 2000, ACVP conference, Amelia Island, FL – Invited Speaker: Evaluating Mutant Mice: Comparative Pathology in Functional Genomics February 14-17, 2001 – Baylor College of Medicine, Houston TX – Pathology of Mutant Animal Models – Conference Organizer, and speaker April 2001 ACLAM Forum. Amelia Island, FL -- Invited Speaker: Rational Approaches to Disease Surveillance and Diagnosis: Challenges of Immunodeficient and Induced Mutant Rodents August 2001 – POLA/CLASS, Rockville, MD -- Invited Speaker: Issues in the Use, Maintenance and Evaluation of Mutant Mice September 2001 – LASA Transgenics Section. UK -- Invited Speaker: Comparative Pathology in Functional Genomics October 2001 CLDavis South Central Pathology Conference, Galveston TX – Course Co-director and Speaker: SV40 induced Rhabdomyosarcoma in a hamster October 2001 – National AALAS, Baltimore MD – Invited Speaker: GEMology session -- I’m the pathologist, and I want the whole mouse February 12-16, 2002 – Baylor College of Medicine, Houston TX – Care and Characterization of Genetically Engineered Mice and Comparative Pathology in Functional Genomics – Conference Organizer, and presenter June 2002 – Massachusetts Institute of Technology, Cambridge, MA – Invited Speaker: Role of Comparative Pathology in Functional Genomics Initiatives July 2002 – The Jackson Laboratory, Bar Harbor, ME: Invited Speaker: Short Course on the Pathobiology of the Modern Laboratory Mouse: Anatomic Phenotyping October 2002 C L Davis South Central Pathology Conference, Galveston TX – Course Co-director and Speaker: SV40 induced Mesotheliomas in hamsters; Argyrophilic spiral bacteria in hamster hepatitis; North American Schistosomiasis October 2002 – National AALAS, Baltimore MD: ACLAD Session – Invited Speaker: Use of GEM in research on infectious agents January 6, 2003 – Albert Einstein College of Medicine, New York City – Invited Speaker: Role of Comparative Pathology in Functional Genomics Initiatives March 31-April 4, 2003 – Pathology of Laboratory Animals; Nantes FR (EuroPOLA I) – Course Co-director and Speaker: Pathology and Phenotyping of Genetically Engineered Mice; Glass Slide review of Laboratory Animal Cases; Practical/Gross Mock Examination July 5-11, 2003 – The Jackson Laboratory, Bar Harbor, ME. Invited Speaker: Short Course on the Pathobiology of the Modern Laboratory Mouse: Anatomic Phenotyping July 21, 2003 – AVMA National Meeting; Denver, CO – Veterinarians in the Post Genomic Era: The need for veterinarians in functional genomics initiatives July 28, 2003 – Yale University, New Haven, CT – Invited Speaker: Phenotyping for Functional Genomics Initiatives August 3, 2003 – Contemporary Topics in Laboratory Animal Sciences Seminar (CLASS), Rockville, MD – Invited Speaker: Issues in the Use, Maintenance and Evaluation of Mutant Mice September 14-21, 2003 -- Second Practical Workshop On The Pathology Of Mouse Models For Human Disease, Cornell University, Ithaca, NY (The Jackson Laboratory, NCRR, MMHCC, MMRRC) -- Invited Speaker: Mouse Necropsy Wet Lab; Infectious and (other) Environmental Phenotypes in Mice; Comparative Pathology Case Conference October 2-4, 2003 CLDavis South Central Pathology Conference, Galveston TX – Course Co-director and Speaker: New(?) Manifestations of Pneumocystosis in Genetically Engineered Mice October 16, 2003 – AALAS National meeting, Seattle, WA -- Invited Speaker: Advances with Genetically Engineered Mice -- Pathology and Phenotyping of Genetically Engineered Mice November 9-12, 2003 – International Mouse Genome Conference, Braunschweig, FRG -- Pathology and Phenotyping of Genetically Engineered Mice January 5-11, 2004 – Pathbase workshop (European Mutant Mouse Pathology Database) Cambridge UK – Invited Speaker: Nature and Nurture – Issues in Phenotyping June 26-29, 2004 – CALAS-ACSAL (Canadian Association of Laboratory Science) Hamilton, ON – Invited Speaker: Phenotyping Transgenic Mice October 17-23, 2004 -- Third Practical Workshop On The Pathology Of Mouse Models For Human Disease, The Jackson Laboratory, Bar Harbor, ME (The Jackson Laboratory, NCRR, MMHCC, MMRRC) -- Invited Speaker: Infectious and (other) Environmental Phenotypes in Mice; November 1-2, 2004 – Understanding Transgenics Workshop; NIEHS, ILS; Research Triangle Park, NC Invited Speaker: How to Decode a Phenotype. April 3, 2005 -- Experimental Biology 2005. San Diego, CA. Invited Speaker: American Society of Investigative Pathology: Mutant animal models symposium: Practical approaches to phenotyping. July 18, 2005 – AVMA National Meeting; Minneapolis, MN – Veterinarians in the Post Genomic Era: The need for veterinarians in functional genomics initiatives August 7-13, 2005 -- Fourth Practical Workshop On The Pathology Of Mouse Models For Human Disease, Purdue university, West Lafayette, IN (The Jackson Laboratory, NCRR, MMHCC, MMRRC) -- Invited Speaker: Infectious and (other) Environmental Phenotypes in Mice; November 8, 2005 – AALAS National meeting, Nov 6-10, 2005. St. Louis, MO Seminar Leader: Practical Phenotyping; Presenter: Getting started; the Bottom line: Pathology correlates of some in vivo phenotypes November 23-26, 2005 – EUMORPHIA Introduction to pathology workshop, Amsterdam, NL. Invited Speaker: Mouse infectious diseases and impact on research December 7, 2005 – ACVP National meeting, Dec 2-7, 2005. Boston, MA. Workshop Leader: Pathology of genetically Engineered Mice; Presenter: Spontaneous pathology of mice and GEM’s February 7, 2006 – Mount Sinai School of Medicine; New York, NY. Invited Speaker: Phenotyping Genetically Engineered Mice: Insights from veterinary pathology on the impacts of nature and nurture on functional genomics initiatives February 14, 2006 – Cornell University, Ithaca, NY. Invited Speaker: GEM Phenotyping: Impacts of nature and nurture on functional genomics March 22, 2006 – Johns Hopkins Phenotyping Symposium, Johns Hopkins University School of Medicine, Baltimore, MD; Conference Director/Organizer, Speaker: Introduction to phenotyping; Anatomic pathology phenotyping April 18, 2006 – Erasmus Institute, Rotterdam, NL. Invited Speaker: Mouse pathology for phenotyping. April 19, 2006 – University of Utrecht, Utrecht, NL. Invited Speaker: Pathology of mice: Infectious diseases and other common phenotypes. April 20, 2006 – Pathologendagen, Ede, NL. Invited Speaker: Spontaneous phenotypes and pathology of genetically engineered mice. May 15-19, 2006 – Pathology of Laboratory Animals; Nantes, France (EuroPOLA II) Course Co-director, Speaker: Diseases and neoplasms (phenotypes) of aging mice 2005 - Phenotyping Committee -- Chair 2005 - Molecular & Comparative Pathobiology Resources Committee -- Member 2005 - Molecular & Comparative Pathobiology Training Education Committee -- Member 2005 - Molecular & Comparative Pathobiology Website Committee -- Member Fall 2005
JHUSOM Molecular & Comparative Pathobiology; Laboratory Animal Medicine: RODENTS: Mouse Pathology: Common phenotypes in commonly used mice March 30, 2006
JHU Animal Care and Use Committee Introduction to Phenotyping and the phenotyping core March 31, 2006
JHU Bloomberg School of Public Health: Toxicology: Mouse pathology: Necropsy not autopsy; Lecture and wet lab April 4, 2006
JHU Bloomberg School of Public Health: Environmental Health Sciences Seminar Series: Impacts of nature and nurture on phenotyping for functional genomics initiatives April 7, 2006
JHUSOM Molecular & Comparative Pathobiology; Slide Seminar: Mouse Hematology May 1, 2006
JHUSOM: Comparative Pathobiology: Comparative respiratory Pathology May 3, 2006
JHU Bloomberg School of Public Health: Toxicology: Mouse respiratory phenotypes | 
