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Kenneth W. Witwer, Ph.D.

Assistant ProfessorKenneth Witwer PhD

Department of Molecular and Comparative Pathobiology - Retrovirus Laboratory

Cellular and Molecular Medicine (http://cmm.jhmi.edu/)

733 N. Broadway
Edward D. Miller Research Building
Room 829
Baltimore, MD 21205

410-955-9770 - Phone
410-955-9823 - Fax

Email: Click Here

Research

Ribonucleic acid (RNA) molecules are found not only inside, but also outside of human cells in biological fluids such as blood plasma, urine, and cerebrospinal fluid. Although quite labile, some RNA molecules are protected from degradation by molecular shuttles including extracellular vesicles (EV). These EV and their nucleic acid cargo may provide early warning of disease, contribute to the defense against disease, and serve as models for effective therapies. Dr. Witwer investigates extracellular vesicles and RNA in the context of HIV infection, inflammatory disease, and other conditions. Related research interests include retrovirus restriction factors and therapeutic delivery of RNA.

Service

  • Board of the International Society for Extracellular Vesicles: member-at-large and chair of the local organizing committee, ISEV 2015
  • Ad hoc reviewer for >30 scientific journals
  • Grant review for NIDDK and the Dutch Technology Foundation STW Grant Program
  • Johns Hopkins Postdoctoral Affairs Advisory Committee
  • Organizer, “Exosome Research Workshop” (February, 2014) and a microRNA-themed journal club (with Marc Halushka, Sam Das)
  • Panelist, US Environmental Protection Agency: Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA-SAP) on RNAi technology as a pesticide (2014) (http://www.epa.gov/scipoly/sap/meetings/2014/january/012814minutes.pdf)

Funded projects (selected):

  • R21 AI102659, "Circulating cellular and extracellular noncoding RNAs in HIV-1 Elite Suppression" (with Dr. Joel Blankson)
  • Johns Hopkins University Center for AIDS Research (1P30AI094189) faculty development award, “Cervicovaginal exosomes and extracellular RNA in HIV infection and resistance”
  • NIMH Center pilot grant, "Development of miRNA-based therapies to silence or purge the latent macrophage reservoir in HAND"
  • R01 NS076357, "Biomarkers of the HIV-associated neurocognitive disorders: plasma and CSF miRNAs in prediction, diagnosis, and pathogenesis of HAND" (PI: Dr. Janice Clements)

Mentees and research opportunities

Dr. Witwer is a faculty member of the Cellular and Molecular Medicine graduate program (http://cmm.jhmi.edu/). Undergraduates and research technologists in the Witwer lab have been co-authors on eight published or submitted journal articles. Students have presented at scientific conferences and received young investigator awards, Provost's Undergraduate Research Awards (PURA), a Dean’s Undergraduate Research Award (DURA), Center for AIDS Research Baltimore HIV Scholars summer awards, and the Second Decade Society scholarship. Students with laboratory experience and a strong interest in HIV, RNA, or EV research are encouraged to inquire about available projects.

Training

Dr. Witwer performed undergraduate research in the laboratory of Dr. Jerry Workman, working closely with Dr. Michael Carrozza. Dr. Witwer earned a doctorate in the Biochemistry, Cellular and Molecular Biology Program at Johns Hopkins, supported by a National Science Foundation Graduate Research Fellowship. Mentored by Dr. Janice Clements, he researched innate immune responses to HIV and related lentiviruses that infect humans, non-human primates, sheep, and goats. Dr. Witwer remained at Johns Hopkins to complete a postdoctoral fellowship in microRNA biomarker research, and he joined the MCP faculty in 2011.

Selected publications

Links

Dr. Witwer's Google Scholar Page

LinkedIn 

ResearchGate  

International Society for Extracellular Vesicles  

American Society for Exosomes and Microvesicles  

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