Skip Navigation
 
 
 
 
 
Print This Page
Share this page: More
 

Joseph L. Mankowski, D.V.M., Ph.D., Diplomate ACVP

 

  • Professor and Acting Director of Dept of Molecular and Comparative PathobiologyJoseph Mankowski
  • Professor of Pathology
  • Professor of Neurology
  • Director of Academic Training, Dept of Molecular and Comparative Pathobiology

Contact Information

733 N. Broadway, MRB 827
Baltimore, MD 21205

410-955-9770 - Lab
410-955-9823 - Fax

Email Dr. Mankowski

Background and Training

B.S. Cornell University, Neurobiology and Behavior
D.V.M. Cornell University
Ph.D. Johns Hopkins University
Diplomate, American College of Veterinary Pathologists

Research Focus

The Mankowski lab group studies the immunopathogenesis of HIV infection using the SIV/macaque model.

Pathogenesis of HIV-induced nervous system and cardiac disease processes

HIV is well known for its ability to induce loss of CD4+ T cells leading to immune suppression manifest as AIDS. HIV infection also causes debilitating disease in the brain, the peripheral nervous system, and in the heart secondary to infection of macrophages. Although virus-induced damage to these organs is common, the pathogenesis remains poorly defined.  Using the SIV/macaque model of HIV, we use a multidisciplinary approach to dissect the mechanisms underlying these diseases, including the central role of macrophage activation. 

Host genetics and lentiviral-induced CNS disease

The role that host genetics play in HIV-associated cognitive disorders is poorly understood.  We have identified a novel association between expression of a MHC class I allele in pigtailed macaques and SIV-induced CNS disease that sets the stage for studies defining how MHC class I-mediated control of SIV replication in the brain influences SIV CNS disease outcomes.

Students and Postdoctoral Fellows

Sarah Beck, DVM, PhD, DACVP – Postdoctoral Fellow

Lisa Mangus, DVM, DACVP - PhD candidate in the Cellular and Molecular Medicine Graduate Program

Research Staff

Suzanne Queen

Jamie Dorsey

Rachel Weinberg

Graduate Program Appointments

Pathobiology Graduate Program

Cellular and Molecular Medicine Graduate Program

Service

Dr. Mankowski provides diagnostic pathology support for the diverse animal species used in biomedical research at Johns Hopkins.

References

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.