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David L. Huso, MD

David L. Huso, D.V.M, Ph.D.

David L. Huso, D.V.M., Ph.D., Dip ACVP

  • Diplomate, American College of Veterinary Pathology
  • Associate Professor, Department of Molecular and Comparative Pathobiology & The Sidney Kimmel Comprehensive Cancer Center

Contact Information

443-287-2953 (phone)
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Background and Training

Dr. Huso completed his Ph.D. training at Johns Hopkins University School of Medicine focusing on molecular pathogenesis and mechanisms of disease while completing an NIH sponsored postdoctoral fellowship in comparative pathology. After his fellowship he achieved board certification from the American College of Veterinary Pathology and received a faculty appointment in the Department of Molecular and Comparative Pathobiology. He initially set up his own research laboratory in Comparative Pathobiology at the Asthma and Allergy Center at the Johns Hopkins Bayview Research Campus. He subsequently moved his laboratory back to the JHMI campus in the Department of Molecular and Comparative Pathobiology.

Current Roles

Dr. Huso mentors a number of individuals both inside and outside the department including students, fellows and staff with research interests in the molecular pathogenesis and treatment of genetic diseases including cancer. He also is director of a graduate school class covering the basics of comparative histology and the development of humanized and engineered mouse models. His research integrates molecular techniques with mouse models to facilitate the movement of preclinical basic science discoveries to the clinic to benefit patients. In addition, he devotes a portion of his time to pathology training of fellows in the department supported by an NIH training grant and provides diagnostic pathology in support of the mouse research colonies at JHU.


Dr. Huso’s laboratory uses the mouse as a genetic system in which to determine mammalian gene function and to elucidate the details of the molecular pathogenesis and treatment of human diseases. This system, along with emerging novel molecular approaches, provides a platform for discovery of underlying disease mechanisms as well as rapid validation of novel targeted therapies using a rational approach based on molecular mechanisms of diseases. Accurate and predictive mouse models are developed and used extensively, not only in discovery of mechanisms and evaluation of efficacy of emerging therapeutic approaches, but also to determine the safety of new therapeutics. Dr. Huso’s research laboratory is made up of persons with diverse backgrounds including students, fellows, assistants and associates with backgrounds in veterinary and human medicine. His current areas of research are highlighted by his publications and includes modeling mechanisms of autoimmune-mediated fibrotic diseases (Stiff Skin Syndrome and Systemic Sclerosis) as well as stem cells and novel therapeutic approaches in IBD and cancer.

Relevant recent articles


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