David L. Huso, D.V.M., Ph.D., Dip ACVP
Diplomate, American College of Veterinary Pathology
Associate Professor, Department of Molecular and Comparative Pathobiology
& The Sidney Kimmel Comprehensive Cancer Center
Background and Training
Dr. Huso received his veterinary degree from Iowa State University and entered private practice following graduation. He then completed a postdoctoral fellowship in comparative pathology at The Johns Hopkins University School of Medicine and achieved board certification from the American College of Veterinary Pathology. Concurrent with his pathology fellowship, he completed his Ph.D. training at Johns Hopkins focusing on molecular pathogenesis and mechanisms of disease. Following his training he received a faculty appointment and started his own research
laboratory in Comparative Medicine at the Johns Hopkins Bayview Research Campus. He has moved his research laboratory back to the JHMI campus and is now Associate Professor in the Department of Molecular and Comparative Pathobiology at The Johns Hopkins University School of Medicine.
Dr. Huso mentors a number of individuals both inside and outside the department with research interests in the molecular pathogenesis of genetic diseases. He also is director of a graduate school class covering the basics of comparative histology and development of genetically engineered mice and other models. His research utilizes molecular techniques and mouse models to facilitate the movement of basic science discoveries to the clinic to benefit patients. In addition, he devotes a portion of his time to pathology training and diagnostic pathology for the research mouse research colonies at JHU.
Dr. Huso’s laboratory uses the mouse as a genetic system in which to determine mammalian gene function and to elucidate the details of the molecular pathogenesis and treatment of human diseases. This system, along with basic molecular techniques, provides a platform for discovery of underlying disease mechanisms as well as rapid validation of noval targeted therapies using a rational approach based on molecular mechanisms of diseases. Accurate and predictive mouse models are developed and used extensively, not only in discovery and evaluation of efficacy of emerging therapeutic approaches, but also to determine the safety of new therapeutics. Dr. Huso’s research laboratory is made up of persons with diverse backgrounds including students, fellows, assistants and associates with backgrounds in veterinary and human medicine.
Relevant recent articles
Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM. Critical role of IRF-5 in regulation of B-cell differentiation. Proc Natl Acad Sci U S A. 2010 Feb 22. [Epub ahead of print]
Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci U S A. 2010. 107:2598-603
Song H, Hobbs RF, Vajravelu R, Huso DL, Esaias C, Apostolidis C, Morgenstern A, Sgouros G. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: comparing efficacy with 213Bi and 90Y. Cancer Res. 2009. 69:8941-8.
Matt P, Huso DL, Habashi J, Holm T, Doyle J, Schoenhoff F, Liu G, Black J, Van Eyk JE, Dietz HC. Murine model of surgically induced acute aortic dissection type A. J Thorac Cardiovasc Surg. 2009 Nov 10. [Epub ahead of print]
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009. 15:1016-22
Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC; GenTAC Consortium Circulating transforming growth factor-beta in Marfan syndrome. Circulation. 2009. 120:526-32.
Di Cello F, Hillion J, Kowalski J, Ronnett BM, Aderinto A, Huso DL, Resar LM. Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. Mol Cancer Ther. 2008. 7:2090-2095.
Karim BO, Ali SZ, Landolfi JA, Mann JF, Liu G, Christian A, Dicello JF, Rosenthal DL, Huso DL. Cytomorphologic differentiation of benign and malignant mammary tumors in fine needle aspirate specimens from irradiated female Sprague-Dawley rats. Vet Clin Pathol. 2008. 37:229-236.
Li L, Piloto O, Nguyen HB, Greenberg K, Takamiya K, Racke F, Huso D, Small D. Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood. 2008. 111:3849-3858.
Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008. 319:476-81.
Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.Biochem Biophys Res Commun. 2008. 367:859-65.
Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG.A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.Nat Med. 2007. 13:1490-5.
Habashi JP, Judge DP, Hom TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, and Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan Syndrome. Science. 2006. 312:117-121
Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C, Vogelstein B, St Croix B, Kinzler KW, and Huso DL. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc Natl Acad Sci U S A. 2006. 103:3351-3356.
Hao LY, Armanios M, Strong MA, Karim B, Feldser DM, Huso D, and Greider CW. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell. 2005. 123:1121-1131.
Diaz LA Jr, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, Garrett-Mayer E, Kobrin B, Pomper M, Zhou S, Kinzler KW, Vogelstein B, and Huso DL. Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicol Sci. 2005. 88:562-575.
Peterson NC, Servinsky MD, Christian A, Peng Z, Qiu W, Mann J, Dicello J, and Huso DL. Tamoxifen resistance and Her2/neu expression in an aged, irradiated rat breast carcinoma model. Carcinogenesis. 2005. 26:1542-1552.
Dicello JF, Christian A, Cucinotta FA, Gridley DS, Kathirithamby R, Mann J, Markham AR, Moyers MF, Novak GR, Piantadosi S, Ricart-Arbona R, Simonson DM, Strandberg JD, Vazquez M, Williams JR, Zhang Y, Zhou H, and Huso D. In vivo mammary tumorigenesis in the Sprague-Dawley rat and microdosimetric correlates. Phys Med Biol. 2004. 49:3817-3830.