Director, Phenotyping (and Pathology) Core
Phone: 410 502 3050
Background and Training
1981 B.A. Williams College
1985 D.V.M. Cornell University,
New York State College of Veterinary Medicine
1997 Diplomate, ACLAM
American College of Laboratory Animal Medicine
1997 Diplomate, ACVP
American College of Veterinary Pathologists
2009-2012 Council, ACVP
2014 President, ACVP
Dr. Brayton received her D.V.M. from Cornell University, and did postdoctoral research and pathology training in New York City at the Animal Medical Center, Cornell University and The Rockefeller University. At The Rockefeller University (1989-1992), she became specifically interested in the pathology and characterization (phenotyping) of genetically engineered mice (GEM), and continued to pursue this interest at several institutions while heading the Facility for Comparative Studies at the Hospital for Special Surgery (1992-1998). At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, and was responsible for health surveillance and diagnostic pathology for a diverse research population including more than 150,000 mice. She also was associate professor in pathology, associate director of the Center for Comparative Medicine, interim attending veterinarian, and served on the IACUC, while pursuing research collaborations, teaching initiatives, and developing national and international conferences on the characterization and pathology of genetically engineered mice.
In 2004 she moved to Johns Hopkins to develop a collaborative phenotyping core based in the Department of Molecular and Comparative Pathobiology (MCP), where veterinarian faculty investigators and trainees provide a unique comparative and translational research resource, in an institution with exceptional resources for multidiscipinary biomedical research. The core supports research with about 100 investigators per year.
The Phenotyping Core aims to facilitate interdisciplinary phenotyping and translational research collaborations, and offers preclinical research pathology support and collaboration. As director of this collaborative core effort, Dr. Brayton reaches out to JHU faculty investigators who wish to participate in multidisciplinary initiatives, and additional participants in the core network are always welcome. Since 2006 we have organized symposia and courses that emphasize JHU resources and faculty, including JHU Phenotyping Symposia in 2006, 2007, 2008, 2009, SOM graduate school course (ME 680.712) in 2007, 2008, and annual Mouse Pathobiology and Phenotyping Short Courses since 2010, and phenotyping and comparative pathology slide conferences. She has become involved in national and international phenotyping initiatives, conferences and courses to promote understanding of mouse biology, pathology and phenotyping in contemporary preclinical translational research.
Dr. Brayton’s primary research interest is in collaborating on pathology and experimental design for many areas of preclinical translational science. Whether caused primarily by spontaneous mutations or infections, by intended genetic manipulations or other experimental interventions, phenotypes and experimental results are impacted by unintended and often under recognized nature and nurture influences. Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as the impact of infectious and other environmental factors on pathology and other phenotypes. She has published on comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and infectious diseases, in mice and other species.
Contact me to discuss phenotyping, collaboration or research pathology needs.
Dr. Brayton’s primary teaching interest is to improve and promote understanding of model organism biology and pathology, especially as it is relevant to phenotyping and experimental design for translational research. She has developed, directed, co-directed, and lectured in symposia, conferences, courses and workshops relevant to phenotyping, pathology, genetics of mice and other laboratory animals, in the US and abroad. She has authored and coauthored books, chapters and invited reviews on mouse biology and pathology. At JHU, she has developed symposia and courses including the Mouse Pathobiology and Phenotyping Short Course, and participates as faculty and lecturer in 680.701 Principles of Animal Pathology and Genetically Engineered Mice; 680.702 LAM/PATH Integrated Problem Solving; 690.707 Experimental Design and Scientific Writing; 680.711 Comparative Pathology Conference; Toxicological Pathology, Bloomberg School of Public Health, and other courses.
Brayton, C; Mckerlie, C; Brown, S. Analysis of Phenotypes (Phenotyping); Chapter 16 in TRANSGENIC ANIMAL TECHNOLOGY 3rd Ed. Pinkert, C Editor. 2014, Elsevier (Academic Press): London. p. 433-487.
Brayton, C. Spontaneous diseases in commonly used mouse strains and stocks. (Outline and resources) 3rd ed. 2013. MPD:Brayton1. Mouse Phenome Database web site, The Jackson Laboratory, Bar Harbor, Maine USA. http://phenome.jax.org/db/q?rtn=projects/projdet&reqprojid=500
Brayton, C. and P. Treuting, Phenotyping, in COMPARATIVE ANATOMY AND HISTOLOGY: A MOUSE AND HUMAN ATLAS P. Treuting and S. Dintzis, Editors. 2012, Elsevier p. 361-381.
Danneman PJ, Suckow MA, Brayton CF.THE LABORATORY MOUSE. 2nd ed. 2012, Taylor and Francis (CRC Press).
Brayton, C., Nature and Nurture: impacts on mouse phenotypes and translational research, in THE MOUSE AS A MODEL ORGANISM, T. Philajaniemi and C. Brakebusch, Editors. 2011, Springer.
Brayton C. Spontaneous diseases in commonly used inbred mouse strains. Chapter 25. Pp 623-717. In Fox. J.G. & al. Ed’s. In THE MOUSE IN BIOMEDICAL RESEARCH 2nd Ed. Vol 3. ACLAM series. 2006, Academic Press.
Brayton C, Nicklas W, Mahler M. Viral Infections. In Hedrich H. Ed. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES: THE LABORATORY MOUSE. 2005, Academic Press.
Suckow MA, Danneman PJ, Brayton CF. THE LABORATORY MOUSE. 1st ed. 2001, CRC Press.
Di Cello1 F, Flowers V, Li H, Vecchio-Pagan B, Gordon B, Harbom K, Shin J, Beaty R, Wang W, Brayton C, Baylin S, Zahnow C. Cigarette smoke induces EMT and breast cancer metastasis. Molecular cancer, 2013. 12: p. 90.
Brayton, C.F., P.M. Treuting, and J.M. Ward, Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design. Veterinary pathology, 2012. 49(1): p. 85-105. Invited Review.
Treuting, P.M., C.B. Clifford, R.S. Sellers, and C.F. Brayton, Of mice and microflora: considerations for genetically engineered mice. Veterinary pathology, 2012. 49(1): p. 44-63. Invited Review.
Sellers, R.S., C.B. Clifford, P.M. Treuting, and C. Brayton, Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice. Veterinary pathology, 2012. 49(1): p. 32-43. Invited Review.
Kut C, Zhang Y, Hedayati M, Zhou H, Cornejo C, Bordelon D, Mihalic J, Wabler M, Burghardt E, Gruettner C, Geyh A, Brayton C, Deweese TL, Ivkov R. Preliminary study of injury from heating systemically delivered, nontargeted dextran-superparamagnetic iron oxide nanoparticles in mice. Nanomedicine (Lond). 2012. 7(11):1697-711.
Ranatunga DC, Ramakrishnan A, Uprety P, Wang F, Zhang H, Margolick JB, Brayton C, Bream JH. A protective role for human IL-10-expressing CD4+ T cells in colitis. Journal of immunology. 2012;189(3):1243-52.
Harris, J.E., Jr., J. Shin, B. Lee, K. Pelosky, C.M. Hooker, K. Harbom, A. Hulbert, C. Zahnow, S.C. Yang, S. Baylin, C. Brayton, and M.V. Brock, A Murine Xenograft Model of Spontaneous Metastases of Human Lung Adenocarcinoma. J Surg Res, 2011.
Bolon, B., B. Altrock, S.W. Barthold, N. Baumgarth, D. Besselsen, G. Boivin, K.L. Boyd, C. Brayton, R.D. Cardiff, S. Couto, K.A. Eaton, O. Foreman, S.M. Griffey, K.L. Perle, M.D. Lairmore, C. Liu, D.K. Meyerholz, A.Y. Nikitin, T.R. Schoeb, D. Schwahn, R.S. Sellers, J.P. Sundberg, R. Tolwani, V.E. Valli, and M.C. Zink, Advancing Translational Research. Science, 2011. 331(6024): p. 1516-1517.
Bolon, B., S.W. Barthold, K.L. Boyd, C. Brayton, R.D. Cardiff, L.C. Cork, K.A. Eaton, T.R. Schoeb, J.P. Sundberg, and J.M. Ward, Male mice not alone in research. Science, 2010. 328(5982): p. 1103.
Gadad, B.S., J.P. Daher, E.K. Hutchinson, C.F. Brayton, T.M. Dawson, M.V. Pletnikov, and J. Watson, Effect of Fenbendazole on Three Behavioral Tests in Male C57BL/6N Mice. J Am Assoc Lab Anim Science, 2010. 49(6): p. 821-5.
Reece JJ, Siracusa MC, Southard TL, Brayton CF, Urban JF Jr, Scott AL. Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung. Infect. Immun. 2008. 76(8): 3511-3524.
Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. 2007. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci. 2007. 27(40):10849-59.
Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. 2007. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem. 2007. 282(44):32264-73.
Iskander K, Gaikwad A, Paquet M, Long DJ 2nd, Brayton C, Barrios R, Jaiswal AK. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005. 65(6):2054-8.
Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003. 71(10):5986-93.
Kogan S; Ward J; Anver M; Berman J; Brayton C; Cardiff R; Carter J; de Coronado S; Downing J; Fredrickson, T; Haines D; Harris A; Harris N; Hiai H; Jaffe E; MacLennan I; Pandolfi P; Pattengale P; Perkins A; Simpson R; Tuttle M; Wong J; Morse H. Bethesda Proposals for Classification of Non-Lymphoid Hematopoietic Neoplasms in Mice. Blood. 2002. 100(1):238-45.
Kato M, Patel M, Levasseur R, Lobov I, Chang B, Glass D, Hartmann C, Li L, Hwang T, Brayton C, Lang R, Karsenty G, Chan L. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002. 157(2):303-14.
Tyner S., Choi J., Jones N, Lu X, Soron G, Cooper B, Brayton C, Karsenty G, Bradley A, Donehower, L. 2002. A germline p53 mutation associated with enhanced tumor resistance and altered longevity in mice. Nature 415, 45–53 (3 January 2002)
Choi J, Nannenga B, Demidov O, Bulavin D, Cooney A, Brayton C, Zhang Y, Mbawuike N, Bradley A, Appella E, Donehower L. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol. 2002. (4):1094-105
Prince J, Brayton C, Fossett M, Durand J, Kaplan S, Smith C, Ballantyne C. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J Immunol. 2001. 15;166(12):7362-9
Brayton CF, Justice MA, Montgomery CA. 2001. Evaluating Mutant Mice: Comparative Pathology. Veterinary Pathology. 38(1):1-19. Invited Review.