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Retrovirus Laboratory | Recent Publications

The last ten most recent publications for each of our faculty is presented. 

 

Dr. Janice Clements

  1. Sisk JM, Witwer KW, Tarwater PM, Clements JE. SIV replication is directly downregulated by four antiviral miRNAs. Retrovirology. 2013;10(1):95. Epub 2013/08/31. doi: 10.1186/1742-4690-10-95. PubMed PMID: 23988154; PMCID: 3766675.
  2. Zaritsky LA, Dery A, Leong WY, Gama L, Clements JE. Tissue-Specific Interferon Alpha Subtype Response to SIV Infection in Brain, Spleen, and Lung. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2013;33(1):24-33. Epub 2012/10/12. doi: 10.1089/jir.2012.0018. PubMed PMID: 23050948; PMCID: 3539257.
  3. Abreu CM, Price SL, Shirk EN, Cunha RD, Pianowski LF, Clements JE, Tanuri A, Gama L. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One. 2014;9(5):e97257. doi: 10.1371/journal.pone.0097257. PubMed PMID: 24827152; PMCID: 4020785.
  4. Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Pena MM, Andersen ES, Christofidou-Solomidou M, Lindl KA, Zink MC, Clements J, Pierce RC, Kolson DL, Jordan-Sciutto KL. Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. J Neurovirol. 2014;20(1):39-53. doi: 10.1007/s13365-013-0227-1. PubMed PMID: 24420448; PMCID: 3928514.
  5. Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF. Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190(7):744-55. doi: 10.1164/rccm.201407-1226OC. PubMed PMID: 25137293; PMCID: 4299615.
  6. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PMCID: 3976595.
  7. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  8. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  9. Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90(12):5643-56. doi: 10.1128/JVI.00290-16. PubMed PMID: 27030272; PMCID: PMC4886778.
  10. Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE. Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection. Am J Pathol. 2016;186(8):2068-87. doi: 10.1016/j.ajpath.2016.03.019. PubMed PMID: 27322772; PMCID: PMC4973662.

Dr. M. Christine Zink

  1. Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. Journal of the American Veterinary Medical Association. 2014;244(3):309-19. doi: 10.2460/javma.244.3.309. PubMed PMID: 24432963.
  2. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015;21(2):148-58. doi: 10.1007/s13365-015-0313-7. PubMed PMID: 25672885.
  3. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  4. Carr BJ, Canapp SO, Jr., Zink MC. Quantitative Comparison of the Walk and Trot of Border Collies and Labrador Retrievers, Breeds with Different Performance Requirements. PLoS One. 2015;10(12):e0145396. doi: 10.1371/journal.pone.0145396. PubMed PMID: 26689372; PMCID: PMC4687030.
  5. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  6. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PMCID: PMC4471292.
  7. Hausmann JC, Wack AN, Allender MC, Cranfield MR, Murphy KJ, Barrett K, Romero JL, Wellehan JF, Blum SA, Zink MC, Bronson E. Experimental Challenge Study of Fv3-Like Ranavirus Infection in Previously Fv3-Like Ranavirus Infected Eastern Box Turtles (Terrapene Carolina Carolina) to Assess Infection and Survival. J Zoo Wildl Med. 2015;46(4):732-46. doi: 10.1638/2015-0022.1. PubMed PMID: 26667529.
  8. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  9. Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90(12):5643-56. doi: 10.1128/JVI.00290-16. PubMed PMID: 27030272; PMCID: PMC4886778.
  10. Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE. Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection. Am J Pathol. 2016;186(8):2068-87. doi: 10.1016/j.ajpath.2016.03.019. PubMed PMID: 27322772; PMCID: PMC4973662.

Dr. Joseph Mankowski

  1. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PMCID: PMC4471292.
  2. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  3. Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015;52(5):883-93. doi: 10.1177/0300985815589354. PubMed PMID: 26077785.
  4. Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90(12):5643-56. doi: 10.1128/JVI.00290-16. PubMed PMID: 27030272; PMCID: PMC4886778.
  5. Beck SE, Queen SE, Viscidi R, Johnson D, Kent SJ, Adams RJ, Tarwater PM, Mankowski JL. Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control. J Neurovirol. 2016;22(4):498-507. doi: 10.1007/s13365-015-0420-5. PubMed PMID: 26727909; PMCID: PMC4925266.
  6. Mangus LM, Dorsey JL, Weinberg RL, Ebenezer GJ, Hauer P, Laast VA, Mankowski JL. Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment. Toxicol Pathol. 2016;44(6):904-12. doi: 10.1177/0192623316650286. PubMed PMID: 27235324; PMCID: PMC4965306.
  7. Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nat Rev Neurol. 2016;12(5):309. doi: 10.1038/nrneurol.2016.53. PubMed PMID: 27080521.
  8. Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol. 2016;12(4):234-48. doi: 10.1038/nrneurol.2016.27. PubMed PMID: 26965674; PMCID: PMC4937456.
  9. Seeley KE, Clayton LA, Hadfield CA, Muth D, Mankowski JL, Kelly KM. Retrospective Review of Mortality in Giant Pacific Octopus (Enteroctopus Dofleini). J Zoo Wildl Med. 2016;47(1):271-4. doi: 10.1638/2014-0134.1. PubMed PMID: 27010286.
  10. Sim RR, Allender MC, Crawford LK, Wack AN, Murphy KJ, Mankowski JL, Bronson E. Ranavirus Epizootic in Captive Eastern Box Turtles (Terrapene Carolina Carolina) with Concurrent Herpesvirus and Mycoplasma Infection: Management and Monitoring. J Zoo Wildl Med. 2016;47(1):256-70. doi: 10.1638/2015-0048.1. PubMed PMID: 27010285.

Dr. David Graham

  1. Royle CM, Graham DR, Sharma S, Fuchs D, Boasso A. HIV-1 and HIV-2 differentially mature plasmacytoid dendritic cells into IFN-producing cells or APCs. J Immunol. 2014;193(7):3538-48. doi: 10.4049/jimmunol.1400860. PubMed PMID: 25156368.
  2. Royle CM, Tsai MH, Tabarrini O, Massari S, Graham DR, Aquino VN, Boasso A. Modulation of HIV-1-induced activation of plasmacytoid dendritic cells by 6-desfluoroquinolones. AIDS Res Hum Retroviruses. 2014;30(4):345-54. doi: 10.1089/AID.2013.0154. PubMed PMID: 24229417; PMCID: 3976578.
  3. Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D, team AA. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol. 2014;20(6):620-6. doi: 10.1007/s13365-014-0292-0. PubMed PMID: 25377444; PMCID: 4268406.
  4. Talman AM, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN, Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJ, Christophides GK, Graham DR, Dinglasan RR, Yates JR, 3rd, Sinden RE. Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. Malar J. 2014;13:315. doi: 10.1186/1475-2875-13-315. PubMed PMID: 25124718; PMCID: 4150949.
  5. Tao D, Ubaida-Mohien C, Mathias DK, King JG, Pastrana-Mena R, Tripathi A, Goldowitz I, Graham DR, Moss E, Marti M, Dinglasan RR. Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology. Mol Cell Proteomics. 2014;13(10):2705-24. doi: 10.1074/mcp.M114.040956. PubMed PMID: 25056935; PMCID: 4188997.
  6. Colquhoun DR, Lyashkov AE, Mohien CU, Aquino VN, Bullock BT, Dinglasan RR, Agnew B, Graham DR. Bio-orthogonal mimetics of palmitoyl-coa and myristoyl-coa and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by hiv-1 infection. Proteomics. 2015. doi: 10.1002/pmic.201500063. PubMed PMID: 25914232.
  7. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  8. Shearer GM, Clerici M, Graham DR, Boasso A. Curing HIV/AIDS beyond hematopoietic stem cell transplant. AIDS. 2015;29(17):2364-6. doi: 10.1097/QAD.0000000000000861. PubMed PMID: 26544708.
  9. Tharakan R, Tao D, Ubaida-Mohien C, Dinglasan RR, Graham DR. Integrated microfluidic chip and online SCX separation allows untargeted nanoscale metabolomic and peptidomic profiling. J Proteome Res. 2015;14(3):1621-6. doi: 10.1021/pr5011422. PubMed PMID: 25574574.
  10. Lukyanenko YO, Younes A, Lyashkov AE, Tarasov KV, Riordon DR, Lee J, Sirenko SG, Kobrinsky E, Ziman B, Tarasova YS, Juhaszova M, Sollott SJ, Graham DR, Lakatta EG. Ca2+/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function. J Mol Cell Cardiol. 2016;98:73-82. doi: 10.1016/j.yjmcc.2016.06.064. PubMed PMID: 27363295.

Dr. Lucio Gama

  1. Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF. Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190(7):744-55. doi: 10.1164/rccm.201407-1226OC. PubMed PMID: 25137293; PMCID: 4299615.
  2. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PMCID: 3976595.
  3. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  4. Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C. An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression. PLoS Pathog. 2015;11(7):e1005063. doi: 10.1371/journal.ppat.1005063. PubMed PMID: 26225566; PMCID: PMC4520688.
  5. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  6. Hosseini I, Gama L, Mac Gabhann F. Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection. PLoS One. 2015;10(5):e0126843. doi: 10.1371/journal.pone.0126843. PubMed PMID: 25984721; PMCID: PMC4436129.
  7. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  8. Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015;89(9):4809-17. doi: 10.1128/JVI.03733-14. PubMed PMID: 25673700; PMCID: PMC4403491.
  9. Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90(12):5643-56. doi: 10.1128/JVI.00290-16. PubMed PMID: 27030272; PMCID: PMC4886778.
  10. Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE. Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection. Am J Pathol. 2016;186(8):2068-87. doi: 10.1016/j.ajpath.2016.03.019. PubMed PMID: 27322772; PMCID: PMC4973662.
Dr. Kenneth Witwer
  1. Eitan E, Zhang S, Witwer KW, Mattson MP. Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth. Journal of extracellular vesicles. 2015;4:26373. doi: 10.3402/jev.v4.26373. PubMed PMID: 25819213; PMCID: 4376846.
  2. Ji Diana Lee Y, Kim V, Muth DC, Witwer KW. Validated MicroRNA Target Databases: An Evaluation. Drug Dev Res. 2015. doi: 10.1002/ddr.21278. PubMed PMID: 26286669.
  3. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PMCID: PMC4529722.
  4. Sherman JH, Munyikwa T, Chan SY, Petrick JS, Witwer KW, Choudhuri S. RNAi Technologies in Agricultural Biotechnology: The Toxicology Forum 40 Annual Summer Meeting. Regul Toxicol Pharmacol. 2015. doi: 10.1016/j.yrtph.2015.09.001. PubMed PMID: 26361858.
  5. Tosar JP, Gambaro F, Sanguinetti J, Bonilla B, Witwer KW, Cayota A. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res. 2015. doi: 10.1093/nar/gkv432. PubMed PMID: 25940616.
  6. Witwer KW. Circulating microRNA biomarker studies: pitfalls and potential solutions. Clinical chemistry. 2015;61(1):56-63. doi: 10.1373/clinchem.2014.221341. PubMed PMID: 25391989.
  7. Witwer KW. Contamination or artifacts may explain reports of plant miRNAs in humans. J Nutr Biochem. 2015;26(12):1685. doi: 10.1016/j.jnutbio.2015.09.004. PubMed PMID: 26456566.
  8. Witwer KW, Buchanan EL, Myers SL, McAlexander MA. miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease. J Neuroinflammation. 2015;12(1):159. doi: 10.1186/s12974-015-0380-y. PubMed PMID: 26337901; PMCID: PMC4559003.
  9. Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, 3rd, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAF V600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid. 2016;26(4):532-42. doi: 10.1089/thy.2015.0378. PubMed PMID: 26950846; PMCID: PMC4827320.
  10. van Dongen HM, Masoumi N, Witwer KW, Pegtel DM. Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery. Microbiol Mol Biol Rev. 2016;80(2):369-86. doi: 10.1128/MMBR.00063-15. PubMed PMID: 26935137; PMCID: PMC4867369.

Dr. Kelly Metcalf Pate

  1. Rice KA, Chen ES, Metcalf Pate KA, Hutchinson EK, Adams RJ. Diagnosis of amyloidosis and differentiation from chronic, idiopathic enterocolitis in rhesus (Macaca mulatta) and pig-tailed (M. nemestrina) macaques. Comp Med. 2013;63(3):262-71. Epub 2013/06/14. PubMed PMID: 23759529; PMCID: 3690432.
  2. Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of Corneal Sensory Nerve Fibers in SIV-Infected Macaques: An Alternate Approach to Investigate HIV-Induced PNS Damage. Am J Pathol. 2014;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. PubMed PMID: 24828391; PMCID: 4044714.
  3. Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. Journal of the American Heart Association. 2014;3(2):e000874. doi: 10.1161/JAHA.114.000874. PubMed PMID: 24695652.
  4. Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. TGFbeta-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection. Journal of acquired immune deficiency syndromes. 2014;65(5):510-6. doi: 10.1097/QAI.0000000000000048. PubMed PMID: 24220290; PMCID: 3999250.
  5. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  6. Freeman ZT, Krall C, Rice KA, Adams RJ, Metcalf Pate KA, Hutchinson EK. Severity and Distribution of Wounds in Rhesus Macaques (Macaca mulatta) Correlate with Observed Self-Injurious Behavior. J Am Assoc Lab Anim Sci. 2015;54(5):516-20. PubMed PMID: 26424249; PMCID: PMC4587619.
  7. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PMCID: PMC4471292.
  8. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  9. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PMCID: PMC4529722.
  10. Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015;52(5):883-93. doi: 10.1177/0300985815589354. PubMed PMID: 26077785.

Dr. Sarah Beck

  1. Hadfield CA, Clayton LA, Clancy MM, Beck SE, Mangus LM, Montali RJ. Proliferative thyroid lesions in three diplodactylid geckos: Nephrurus amyae, Nephrurus levis, and Oedura marmorata. J Zoo Wildl Med. 2012;43(1):131-40. PubMed PMID: 22448520.
  2. Wenzel AR, Wack AN, Beck SE, Bronson E. Pathology in practice. Nasal and nasopharyngeal polyps. Journal of the American Veterinary Medical Association. 2012;241(7):885-7. doi: 10.2460/javma.241.7.885. PubMed PMID: 23013500; PMCID: 3771105.
  3. Kelly KM, Beck SE, Metcalf Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery LB, Hubbard W, Tarwater PM, Mankowski JL. Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain. AIDS. 2013;27(18):F21-8. doi: 10.1097/QAD.0000000000000074. PubMed PMID: 24051706; PMCID: 4235167.
  4. Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. Am J Pathol. 2014;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. PubMed PMID: 24828391; PMCID: 4044714.
  5. Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. Journal of the American Heart Association. 2014;3(2):e000874. doi: 10.1161/JAHA.114.000874. PubMed PMID: 24695652; PMCID: 4187513.
  6. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015;21(2):148-58. doi: 10.1007/s13365-015-0313-7. PubMed PMID: 25672885.
  7. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  8. Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci U S A. 2015;112(6):1880-5. doi: 10.1073/pnas.1417949112. PubMed PMID: 25583515; PMCID: 4330748.
  9. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PMCID: PMC4529722.
  10. Beck SE, Queen SE, Viscidi R, Johnson D, Kent SJ, Adams RJ, Tarwater PM, Mankowski JL. Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control. J Neurovirol. 2016;22(4):498-507. doi: 10.1007/s13365-015-0420-5. PubMed PMID: 26727909; PMCID: PMC4925266.

Dr. Lisa Mangus

  1. Carroll EE, Fossey SL, Mangus LM, Carsillo ME, Rush LJ, McLeod CG, Johnson TO. Malignant pilomatricoma in 3 dogs. Vet Pathol. 2010;47(5):937-43. doi: 10.1177/0300985810371310. PubMed PMID: 20466858.
  2. Hadfield CA, Clayton LA, Clancy MM, Beck SE, Mangus LM, Montali RJ. Proliferative thyroid lesions in three diplodactylid geckos: Nephrurus amyae, Nephrurus levis, and Oedura marmorata. J Zoo Wildl Med. 2012;43(1):131-40. doi: 10.1638/2011-0106.1. PubMed PMID: 22448520.
  3. Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. Am J Pathol. 2014;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. PubMed PMID: 24828391; PMCID: PMC4044714.
  4. Mangus LM, Dorsey JL, Laast VA, Ringkamp M, Ebenezer GJ, Hauer P, Mankowski JL. Unraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 2014;54(3):296-303. doi: 10.1093/ilar/ilt047. PubMed PMID: 24615443; PMCID: PMC3962261.
  5. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015;759:303-12. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747; PMCID: PMC4731094.
  6. Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. J Neuropathol Exp Neurol. 2015;74(11):1053-60. doi: 10.1097/NEN.0000000000000249. PubMed PMID: 26426267; PMCID: PMC4607660.
  7. Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL. Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques. J Neuropathol Exp Neurol. 2015;74(1):38-47. doi: 10.1097/NEN.0000000000000148. PubMed PMID: 25470348; PMCID: PMC4270881.
  8. Mangus LM, Dorsey JL, Weinberg RL, Ebenezer GJ, Hauer P, Laast VA, Mankowski JL. Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment. Toxicol Pathol. 2016;44(6):904-12. doi: 10.1177/0192623316650286. PubMed PMID: 27235324; PMCID: PMC4965306.