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Retrovirus Laboratory | Recent Publications

The last ten most recent publications for each of our faculty is presented. 

 

Dr. Janice Clements

  1. Liu J, Sisk JM, Gama L, Clements JE, Witwer KW. Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Molecular brain. 2013;6:40. doi: 10.1186/1756-6606-6-40. PubMed PMID: 24103357; PubMed Central PMCID: PMC3766027. PMCID: 3766027
  2. Russell JN, Clements JE, Gama L. Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells. PLoS One. 2013;8(9):e73849. Epub 2013/09/12. doi: 10.1371/journal.pone.0073849. PubMed PMID: 24023909; PubMed Central PMCID: PMC3759445. PMCID: 3759445
  3. Sisk JM, Witwer KW, Tarwater PM, Clements JE. SIV replication is directly downregulated by four antiviral miRNAs. Retrovirology. 2013;10(1):95. Epub 2013/08/31. doi: 10.1186/1742-4690-10-95. PubMed PMID: 23988154; PubMed Central PMCID: PMC3766675. PMCID: 3766675
  4. Zaritsky LA, Dery A, Leong WY, Gama L, Clements JE. Tissue-Specific Interferon Alpha Subtype Response to SIV Infection in Brain, Spleen, and Lung. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2013;33(1):24-33. Epub 2012/10/12. doi: 10.1089/jir.2012.0018. PubMed PMID: 23050948; PubMed Central PMCID: PMC3539257. PMCID: 3539257
  5. Abreu CM, Price SL, Shirk EN, Cunha RD, Pianowski LF, Clements JE, Tanuri A, Gama L. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One. 2014;9(5):e97257. doi: 10.1371/journal.pone.0097257. PubMed PMID: 24827152; PubMed Central PMCID: PMC4020785. PMCID: 4020785
  6. Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Pena MM, Andersen ES, Christofidou-Solomidou M, Lindl KA, Zink MC, Clements J, Pierce RC, Kolson DL, Jordan-Sciutto KL. Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. J Neurovirol. 2014;20(1):39-53. doi: 10.1007/s13365-013-0227-1. PubMed PMID: 24420448; PubMed Central PMCID: PMC3928514. PMCID: 3928514
  7. Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF. Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190(7):744-55. doi: 10.1164/rccm.201407-1226OC. PubMed PMID: 25137293; PubMed Central PMCID: PMC4299615. PMCID: 4299615
  8. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PubMed Central PMCID: PMC3976595. PMCID: 3976595
  9. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  10. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388. 

Dr. M. Christine Zink

  1. Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC. Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol. 2014. doi: 10.1007/s13365-014-0283-1. PubMed PMID: 25227932.
  2. Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC. Elevated Brain Monoamine Oxidase Activity in SIV- and HIV-associated Neurological Disease. J Infect Dis. 2014. doi: 10.1093/infdis/jiu194. PubMed PMID: 24688074.
  3. Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D, team AA. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV- seropositive individuals with cognitive impairment. J Neurovirol. 2014;20(6):620-6. doi: 10.1007/s13365-014-0292-0. PubMed PMID: 25377444; PubMed Central PMCID: PMC4268406. PMCID: 4268406
  4. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PubMed Central PMCID: PMC3976595. PMCID: 3976595
  5. Zink MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. Journal of the American Veterinary Medical Association. 2014;244(3):309-19. doi: 10.2460/javma.244.3.309. PubMed PMID: 24432963.
  6. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015;21(2):148-58. doi: 10.1007/s13365-015-0313-7. PubMed PMID: 25672885.
  7. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  8. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  9. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PubMed Central PMCID: PMCPMC4471292. PMCID: PMC4471292
  10. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388. 

Dr. Joseph Mankowski

  1. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PMCID: 3976595.
  2. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015;21(2):148-58. doi: 10.1007/s13365-015-0313-7. PubMed PMID: 25672885.
  3. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  4. Brew BJ, Robertson K, Wright EJ, Churchill M, Crowe SM, Cysique LA, Deeks S, Garcia JV, Gelman B, Gray LR, Johnson T, Joseph J, Margolis DM, Mankowski JL, Spencer B. HIV eradication symposium: will the brain be left behind? J Neurovirol. 2015. doi: 10.1007/s13365-015-0322-6. PubMed PMID: 25750070.
  5. Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. J Neuropathol Exp Neurol. 2015. doi: 10.1097/NEN.0000000000000249. PubMed PMID: 26426267.
  6. Dorsey JL, Mangus LM, Hauer P, Ebenezer GJ, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. J Neuropathol Exp Neurol. 2015;74(11):1053-60. doi: 10.1097/NEN.0000000000000249. PubMed PMID: 26426267; PMCID: PMC4607660.
  7. Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci U S A. 2015;112(6):1880-5. doi: 10.1073/pnas.1417949112. PubMed PMID: 25583515; PMCID: 4330748.
  8. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PMCID: PMC4471292.
  9. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  10. Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015;52(5):883-93. doi: 10.1177/0300985815589354. PubMed PMID: 26077785.

Dr. David Graham

  1. Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC. Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol. 2014. doi: 10.1007/s13365-014-0283-1. PubMed PMID: 25227932.
  2. Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC. Elevated Brain Monoamine Oxidase Activity in SIV- and HIV-associated Neurological Disease. J Infect Dis. 2014. doi: 10.1093/infdis/jiu194. PubMed PMID: 24688074.
  3. Royle CM, Graham DR, Sharma S, Fuchs D, Boasso A. HIV-1 and HIV-2 differentially mature plasmacytoid dendritic cells into IFN-producing cells or APCs. J Immunol. 2014;193(7):3538-48. doi: 10.4049/jimmunol.1400860. PubMed PMID: 25156368.
  4. Royle CM, Tsai MH, Tabarrini O, Massari S, Graham DR, Aquino VN, Boasso A. Modulation of HIV-1-induced activation of plasmacytoid dendritic cells by 6-desfluoroquinolones. AIDS Res Hum Retroviruses. 2014;30(4):345-54. doi: 10.1089/AID.2013.0154. PubMed PMID: 24229417; PubMed Central PMCID: PMC3976578. PMCID: 3976578
  5. Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D, team AA. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol. 2014;20(6):620-6. doi: 10.1007/s13365-014-0292-0. PubMed PMID: 25377444; PubMed Central PMCID: PMC4268406. PMCID: 4268406
  6. Talman AM, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN, Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJ, Christophides GK, Graham DR, Dinglasan RR, Yates JR, 3rd, Sinden RE. Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. Malar J. 2014;13:315. doi: 10.1186/1475-2875-13-315. PubMed PMID: 25124718; PubMed Central PMCID: PMC4150949. PMCID: 4150949
  7. Tao D, Ubaida-Mohien C, Mathias DK, King JG, Pastrana-Mena R, Tripathi A, Goldowitz I, Graham DR, Moss E, Marti M, Dinglasan RR. Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology. Mol Cell Proteomics. 2014;13(10):2705-24. doi: 10.1074/mcp.M114.040956. PubMed PMID: 25056935; PubMed Central PMCID: PMC4188997. PMCID: 4188997
  8. Colquhoun DR, Lyashkov AE, Mohien CU, Aquino VN, Bullock BT, Dinglasan RR, Agnew B, Graham DR. Bio-orthogonal mimetics of palmitoyl-coa and myristoyl-coa and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by hiv-1 infection. Proteomics. 2015. doi: 10.1002/pmic.201500063. PubMed PMID: 25914232.
  9. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  10. Tharakan R, Tao D, Ubaida-Mohien C, Dinglasan RR, Graham DR. Integrated microfluidic chip and online SCX separation allows untargeted nanoscale metabolomic and peptidomic profiling. J Proteome Res. 2015;14(3):1621-6. doi: 10.1021/pr5011422. PubMed PMID: 25574574. 
Dr. Lucio Gama
  1. Abreu CM, Price SL, Shirk EN, Cunha RD, Pianowski LF, Clements JE, Tanuri A, Gama L. Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One. 2014;9(5):e97257. doi: 10.1371/journal.pone.0097257. PubMed PMID: 24827152; PubMed Central PMCID: PMC4020785. PMCID: 4020785
  2. Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC. Elevated Brain Monoamine Oxidase Activity in SIV- and HIV-associated Neurological Disease. J Infect Dis. 2014. doi: 10.1093/infdis/jiu194. PubMed PMID: 24688074.
  3. Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF. Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190(7):744-55. doi: 10.1164/rccm.201407-1226OC. PubMed PMID: 25137293; PubMed Central PMCID: PMC4299615. PMCID: 4299615
  4. Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. AIDS Res Hum Retroviruses. 2014;30(4):333-4. doi: 10.1089/aid.2014.0029. PubMed PMID: 24697643; PubMed Central PMCID: PMC3976595. PMCID: 3976595
  5. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  6. Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C. An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression. PLoS Pathog. 2015;11(7):e1005063. doi: 10.1371/journal.ppat.1005063. PubMed PMID: 26225566; PubMed Central PMCID: PMCPMC4520688. PMCID: PMC4520688
  7. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  8. Hosseini I, Gama L, Mac Gabhann F. Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection. PLoS One. 2015;10(5):e0126843. doi: 10.1371/journal.pone.0126843. PubMed PMID: 25984721; PubMed Central PMCID: PMCPMC4436129. PMCID: PMC4436129
  9. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  10. Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015;89(9):4809-17. doi: 10.1128/JVI.03733-14. PubMed PMID: 25673700; PubMed Central PMCID: PMCPMC4403491. PMCID: PMC4403491
Dr. Kenneth Witwer
  1. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  2. Buchanan EL, McAlexander MA, Witwer KW. SAMHD1 expression in blood cells of HIV-1 elite suppressors and viraemic progressors. J Antimicrob Chemother. 2015;70(3):954-6. doi: 10.1093/jac/dku428. PubMed PMID: 25344600; PubMed Central PMCID: PMC4319484. PMCID: 4319484
  3. Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol. 2015. doi: 10.1007/s13365-015-0334-2. PubMed PMID: 25776527.
  4. Eitan E, Zhang S, Witwer KW, Mattson MP. Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth. Journal of extracellular vesicles. 2015;4:26373. doi: 10.3402/jev.v4.26373. PubMed PMID: 25819213; PubMed Central PMCID: PMC4376846. PMCID: 4376846
  5. Ji Diana Lee Y, Kim V, Muth DC, Witwer KW. Validated MicroRNA Target Databases: An Evaluation. Drug Dev Res. 2015. doi: 10.1002/ddr.21278. PubMed PMID: 26286669.
  6. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PubMed Central PMCID: PMCPMC4529722. PMCID: PMC4529722
  7. Sherman JH, Munyikwa T, Chan SY, Petrick JS, Witwer KW, Choudhuri S. RNAi Technologies in Agricultural Biotechnology: The Toxicology Forum 40 Annual Summer Meeting. Regul Toxicol Pharmacol. 2015. doi: 10.1016/j.yrtph.2015.09.001. PubMed PMID: 26361858.
  8. Tosar JP, Gambaro F, Sanguinetti J, Bonilla B, Witwer KW, Cayota A. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res. 2015. doi: 10.1093/nar/gkv432. PubMed PMID: 25940616.
  9. Witwer KW. Circulating microRNA biomarker studies: pitfalls and potential solutions. Clinical chemistry. 2015;61(1):56-63. doi: 10.1373/clinchem.2014.221341. PubMed PMID: 25391989.
  10. Witwer KW, Buchanan EL, Myers SL, McAlexander MA. miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease. J Neuroinflammation. 2015;12(1):159. doi: 10.1186/s12974-015-0380-y. PubMed PMID: 26337901; PubMed Central PMCID: PMCPMC4559003. PMCID: PMC4559003
Dr. Kelly Metcalf Pate
  1. Rice KA, Chen ES, Metcalf Pate KA, Hutchinson EK, Adams RJ. Diagnosis of amyloidosis and differentiation from chronic, idiopathic enterocolitis in rhesus (Macaca mulatta) and pig-tailed (M. nemestrina) macaques. Comp Med. 2013;63(3):262-71. Epub 2013/06/14. PubMed PMID: 23759529; PubMed Central PMCID: PMC3690432. PMCID: 3690432
  2. Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of Corneal Sensory Nerve Fibers in SIV-Infected Macaques: An Alternate Approach to Investigate HIV-Induced PNS Damage. Am J Pathol. 2014;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. PubMed PMID: 24828391; PubMed Central PMCID: PMC4044714. PMCID: 4044714
  3. Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. Journal of the American Heart Association. 2014;3(2):e000874. doi: 10.1161/JAHA.114.000874. PubMed PMID: 24695652.
  4. Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. TGFbeta-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection. Journal of acquired immune deficiency syndromes. 2014;65(5):510-6. doi: 10.1097/QAI.0000000000000048. PubMed PMID: 24220290; PubMed Central PMCID: PMC3999250. PMCID: 3999250
  5. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  6. Freeman ZT, Krall C, Rice KA, Adams RJ, Metcalf Pate KA, Hutchinson EK. Severity and Distribution of Wounds in Rhesus Macaques (Macaca mulatta) Correlate with Observed Self-Injurious Behavior. J Am Assoc Lab Anim Sci. 2015;54(5):516-20. PubMed PMID: 26424249; PubMed Central PMCID: PMCPMC4587619. PMCID: PMC4587619
  7. Freeman ZT, Rice KA, Soto PL, Pate KA, Weed MR, Ator NA, DeLeon IG, Wong DF, Zhou Y, Mankowski JL, Zink MC, Adams RJ, Hutchinson EK. Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior. Transl Psychiatry. 2015;5:e567. doi: 10.1038/tp.2015.61. PubMed PMID: 25989141; PubMed Central PMCID: PMCPMC4471292. PMCID: PMC4471292
  8. Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. J Infect Dis. 2015. doi: 10.1093/infdis/jiv230. PubMed PMID: 25883388.
  9. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PubMed Central PMCID: PMCPMC4529722. PMCID: PMC4529722
  10. Olson EJ, Shaw GC, Hutchinson EK, Schultz-Darken N, Bolton ID, Parker JB, Morrison JM, Baxter VK, Pate KA, Mankowski JL, Carlson CS. Bone Disease in the Common Marmoset: Radiographic and Histological Findings. Vet Pathol. 2015;52(5):883-93. doi: 10.1177/0300985815589354. PubMed PMID: 26077785. 

Dr. Sarah Beck

  1. Del Carmen Martino-Cardona M, Beck SE, Brayton C, Watson J. Eradication of Helicobacter spp. by using medicated diet in mice deficient in functional natural killer cells and complement factor D. J Am Assoc Lab Anim Sci. 2010;49(3):294-9. PubMed PMID: 20587159; PubMed Central PMCID: PMC2877300. PMCID: 2877300
  2. Hadfield CA, Clayton LA, Clancy MM, Beck SE, Mangus LM, Montali RJ. Proliferative thyroid lesions in three diplodactylid geckos: Nephrurus amyae, Nephrurus levis, and Oedura marmorata. J Zoo Wildl Med. 2012;43(1):131-40. PubMed PMID: 22448520.
  3. Wenzel AR, Wack AN, Beck SE, Bronson E. Pathology in practice. Nasal and nasopharyngeal polyps. Journal of the American Veterinary Medical Association. 2012;241(7):885-7. doi: 10.2460/javma.241.7.885. PubMed PMID: 23013500; PubMed Central PMCID: PMC3771105. PMCID: 3771105
  4. Kelly KM, Beck SE, Metcalf Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery LB, Hubbard W, Tarwater PM, Mankowski JL. Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain. AIDS. 2013;27(18):F21-8. doi: 10.1097/QAD.0000000000000074. PubMed PMID: 24051706; PubMed Central PMCID: PMC4235167. PMCID: 4235167
  5. Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. Am J Pathol. 2014;184(6):1652-9. doi: 10.1016/j.ajpath.2014.02.009. PubMed PMID: 24828391; PubMed Central PMCID: PMC4044714. PMCID: 4044714
  6. Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. Journal of the American Heart Association. 2014;3(2):e000874. doi: 10.1161/JAHA.114.000874. PubMed PMID: 24695652; PubMed Central PMCID: PMC4187513. PMCID: 4187513
  7. Beck SE, Kelly KM, Queen SE, Adams RJ, Zink MC, Tarwater PM, Mankowski JL. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol. 2015;21(2):148-58. doi: 10.1007/s13365-015-0313-7. PubMed PMID: 25672885.
  8. Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. Eur J Pharmacol. 2015. doi: 10.1016/j.ejphar.2015.03.018. PubMed PMID: 25818747.
  9. Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci U S A. 2015;112(6):1880-5. doi: 10.1073/pnas.1417949112. PubMed PMID: 25583515; PubMed Central PMCID: PMC4330748. PMCID: 4330748
  10. Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. BMC Vet Res. 2015;11:187. doi: 10.1186/s12917-015-0513-7. PubMed PMID: 26253321; PubMed Central PMCID: PMCPMC4529722. PMCID: PMC4529722