Recommended Phenotyping Strategy

Some resources/services are available on a fee for service basis, for larger or long term projects, collaborative agreements usually are developed. 

Participating core investigators / faculty can be contacted from the
Core Faculty and Resources page or from 
Currently Available Phenotyping Assessments / Tests page, or by contacting 
Phenocore@jhmi.edu.    

For phenotyping projects, an interactive approach, involving communication and collaboration between laboratory faculty/staff/students and phenotyping faculty/staff/students, as well as training of project personnel, is recommended, generally according to the progression below:

WHAT HAPPENS TO MICE

Tier 1 

1. In vivo testing (clinical behavioral exam, hematology, chemistry)
2. In vivo tests may be repeated at various times throughout an individual's lifespan.
3. Terminal baseline testing – comprehensive necropsy (clinical pathology, photo etc imaging, weights/measurements, histopathology 30+ tissues).

Tier 2

1. Specialized (targeted) in vivo testing (mazes, acoustic startle, rotarod, MRI, SPECT, microPET, Faxitron, Metabolic/physiologic evaluations, FACS on blood). 
2. In vivo tests may be repeated at various times throughout an individual's lifespan.
3. Specialized (targeted) terminal testing (e.g. necropsy to include special dissections, perfusions, fixations, specimen preparation for FACS, ISH, IHC, etc special techniques on specific tissues.

GO TO: Currently Available Phenotyping Assessments / Tests page

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