Phenotyping Course Schedule 07

Lecture 6, January 25, 2007

Cory Brayton, DVM, Diplomate ACLAM, ACVP
Director, Phenotyping Core
Associate Professor, Molecular and Comparative Pathobiology

Anatomic Pathology for Mouse Phenotyping
PDF of the PPT presentation
PDF of our necropsy protocol
PDF of our necropsy form

  
Dawn Ruben, DVM, MS
Resident, Comparative Medicine, Molecular and Comparative Pathobiology

Clinical Pathology for Mouse Phenotyping
PDF of Dr. Ruben's PPT presentation 
PDF of Dr. Brayton's handout on hematology and differential evaluation
PDF of Ms. Forbes' handout on Hemavet and CBC recommendations  
PDF of Dr. Ruben's handout of clinical chemistry recommendations

GO TO Pathology and other testing available through our Phenotyping Core.
  

Internet Resources

GO TO EMPRESS Phenotyping Platform
Clinical chemistry and haematology; Necropsy exam; etc.

GO TO NIH Virtual Mouse Necropsy

GO TO RENI Toxicologic Pathology Tissue trimming Guide

Additional References

Brayton, C., M. Justice, Montgomery, C. (2001). "Evaluating mutant mice: anatomic pathology." Vet Pathol 38(1): 1-19.

Car, B. D. and V. M. Eng (2001). "Special considerations in the evaluation of the hematology and hemostasis of mutant mice." Vet Pathol 38(1): 20-30 (PUBMED).

Fox.  J.G. & al. Ed’s.  In THE MOUSE IN BIOMEDICAL RESEARCH  2nd Ed.  ACLAM series.  Elsevier.  Chapters on Clinical Pathology and Diseases.

Hedrich H. Ed.  2004. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES:  THE LABORATORY MOUSE. Elsevier.  Chapters on Clinical Pathology and Histology

Hrabé de Angelis, M.& al. Ed's. 2006. STANDARDS OF MOUSE MODEL PHENOTYPING.  Wiley-VCH, Weinheim, ISBN 3-527-31031-2

Suckow M, Danneman P, Brayton C.  2001. THE LABORATORY MOUSE. CRC Press, Boca Raton, FL, . (Taylor & Francis, UK).

Sundberg JP & Boggess D, Ed’s.  2002. Systematic Approach to Evaluation of Mouse Mutations.  CRC Press, Boca Raton, FL. (Taylor & Francis, UK) Chapter on necropsy, fixatives, trimming