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Specialized Mouse (& Rat) NeuroBehavioral Testing in BRB


Mikhail Pletnikov, MD, PhD

Rodent Behavioral Core Director
Associate Professor
Division of Neurobiology
Department of Psychiatry and Behavioral Sciences

Contact Jennifer Yocum MA by email, or call 410 502 4259
for scheduling & additional information

Contact  Dr. Pletnikov for information about:

  • Collaboration
  • Test selection
  • Data analysis
 
 
 

 
FOR MICE

 
Motor coordination
Balance
Muscle strength

Rotarod apparatus in BRB

Rotarod + Accelerating Rotarod

Also
Forced Swim Test

Fearfulness

Anxiety


Open Field Apparatus in BRB

Elevated Plus Maze
  • Open arm entries
  • Time spent in open vs. closed? arms
Open Field Test
  • Horizontal activity
    • Peripheral (thigmotactic)
    • Central
  • Vertical activity (rearing)
  • Grooming
  • Freezing
Conditioned Fear responses:
  • Freezing
  • Autonomic responses
    • heart rate
    • breathing
    • defecation
Sensorimotor integration
Startle Appartus in BRB
Acoustic Startle Response
  • Habituation
  • Pre-pulse inhibition

Also
Heat Sensitization

Learning
Cognitive Functions

 

 

    

Y Maze
T Maze
Morris Water Maze
Tail Suspension (learned helplessness)

Social Functions

 

   

Social interaction (same & opposite sex)
Ultrasonic Vocalization detection (singing)
 

    
FOR RATS

 
Motor coordination
Balance
Muscle strength
 

Rotarod
Beamwalk
Gridwalk / Horizontal Ladder
Footprint
Gait Analysis

Fearfulness
Anxiety

   

BBB (open field / locomotor)
Fear Conditioning
Sensorimotor

   

 

Startle Response (PPI)

LearningCognitive Functions

  

 


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