Hosted by the Department of Molecular and Comparative Pathobiology, this is an informal monthly slide conference that emphasizes recent interesting phenotyping and comparative pathology cases, and provides a friendly and educational venue for colleagues within and outside of the JHU community to present and discuss cases. Date: usually the 3rd or 4th Tuesday of each month. Date confirmation will be sent to interested individuals approximately 10 days in advance. UPCOMING CONFERENCE DATES (subject to change, Contact Dr. Brayton to receive email notifications): Tuesday March 18, 2008 Time: 4:00pm-6:00pm. RECENT CASES February 20, 2008 (post symposium Aperio virtual slide conference) Dr.'s Southard, Brayton - Mouse (Tg, B6C3) with posterior paresis - Disseminated lymphoma leukemia, vertebra, spinal canal, muscle (also spleen, liver, thymus, lymph nodes) Dr.'s Southard, Brayton - Mouse (tm, IL10 ) with posterior paresis - Histiocytic sarcoma, vertebra, spinal canal, muscle Dr. Singh - Mouse (tm, Er2a ) Ovaries, testes, subfertile phenotype Dr, Sebastian - Cat - kidney - Melamine toxicity Dr. Simons - Mouse (tm, B6,129) - Kidneys congenital renal cysts Dr. Simons - Mouse - liver - tumors Dr.'s Shaw, Brayton - LE rat - femur - endosteal bone proliferation Dr.'s Southard, Brayton - Tg rat - Eyes - congenital cataracts Dr.'s Southard, Brayton - Mouse (NOD SCID IL-2R g tm) bacteremia, SFB Dr.'s Lelly, Montali - Mouse (tm Rag1) - Skin - Hyperkeratosis Acanthosis bacteria cw C bovis (HAC) Dr.'s Southard, Brayton - Mouse (tm Rag1, etc ) - Kidney - diffuse intranuclear inclusion bodies Dr.'s Southard, Brayton - Mouse (tm, B6,129 ) Rectum, colon - nematode larvae, flagellate protozoa Dr.'s Southard, Brayton - Mouse (tm, B6,129 ) decalcified head - otitis, rhinitis, fibroosseous lesion, PAS + 'tauopathy' Dr.'s Bailey, Brayton - Mouse (tm, B6,129 ) decalcified head - Mast cell tumor, nasal 'amyloidosis' Dr.'s Southard, Brayton - Mouse (+/+, B6,129 ) decalcified head - Pituitary tumor Dr.'s Southard, Brayton - Mouse (ICR (CD1) sentinel) decalcified head - malacia / infarct Dr.'s Southard, Brayton - Mouse (tm, B6,129) decalcified head - arteritis polyarteritis, periarteritis Dr.'s Southard, Brayton - Mouse (?? F) heart - left atrial thrombus, 'cardiomyopathy' Dr.'s Gluckman, Brayton - Mouse (nu/nu ) salivary glands, intestine - amyloidosis Dr.'s Tembley, Brayton - Mouse (Tg ?) Lung - primary lung carcinoma + metastasis Dr.'s Simon, Brayton - LE rat - heart - myocyte degneration loss fibrosis mineralization (cardiomyopathy) Dr.'s Simon, Brayton - LE rat - kidney- tubule degeneration loss regeneration, interstitial fibrosis inflammation; glomerulosclerosis (nephropathy) Dr.'s Simon, Brayton - 'wild' mouse - kidney- klossiellosis January 15, 2008 Dr.'s Southard, Brayton - Mouse (Tg, B6C3) with posterior paresis - Disseminated lymphoma leukemia, vertebra, spinal canal, muscle (also spleen, liver, thymus, lymph nodes) Dr. Montali - Rabbit - Mandible bacterial osteomyelitis, with Splendore Hoeppli Dr. Southard - Rat (LE) - heart sarcoma, r/o schwannoma Dr. Southard - Rat (LE)- skin, keratoacanthoma, squamous cell carcinoma Dr.'s Shaw, Montali - Carpet Python - CNS Etc tissues Intranuclear Inclusion Bodies, possibly paramyxovirus Dr.'s Shaw, Montali - Snowy Owl - Liver Kidney schizonts, avian malaria, P relictum Dr.'s Southard, Brayton - Mouse (Tg, B6C3) - Amyloidosis, parotid glands, liver, spleen, intestine Dr.'s Southard, Brayton - Mouse (Tg, B6C3) - Liver hepatoblastoma Dr.'s Southard, Brayton - mouse (IL10 tm) - otitis media, laryngotracheitis November 27, 2007Dr.'s Schultz, Poynton, Montali - Octopus - Branchitis, Icthyobodo spp. Dr.'s Shaw, Montali - Sheepshead minnow - myxosporidiosis, spinal cord Dr.'s Southard, Montali, Brayton - Beta fish - iridophoroma Dr. Karim - Ray coelom mass FNA - neoplasia, epithelial Dr. Pierce - Llama - Spinal cord nematodes consistent with P tenuis Dr.'s Pierce, Kelley - Ox - Rabies Dr.'s Schultz, Montali - Macaca silenus - odontogenic neoplasm Dr. Simons - WT for conditional mutant mouse on mixed background - multiple intestinal adenomas October 23, 2007 Dr.'s Schultz, Brayton - NZW rabbit - Trachea CARbacillus; Pneumonia, bronchopneumonia, Gram negative bacteria, r/o pasteurellosis Dr.'s Southard, Brayton - tm and C57BL/6? mice - hepatitis, splenitis, typhlitis, otitis, encephalitis; Salmonellosis, etc Dr.'s Kelley, Karim - C57BL/6? mice - Sarcoma, toe; histiocytic sarcoma, liver Dr.'s Kelley, Huso - Chinchilla - Pyelonephritis with Candida tropicalis isolated; Diabetes mellitus? Dr.'s Schultz, Montali - Macaca silenus - nephropblastoma Dr.'s Simons, Montali - Degu - Chronic glomerulonephritis nephropathy; Pancreatic insular amyloidosis, Diabetes mellitus Dr. Simons - rat - Chronic nephropathy, glomerulonephritis Dr.'s Simons, Montali - Fruit bat - Renal coccidiosis, cw Klossiella spp Dr.'s Simons, Montali - Ferret - vasculitis perivasculitis, cw FIP-like Coronavirus September 18, 2007Dr.'s Brayton, Montali, Manasse - Budgerigars, etc psittacines - Macrorhabdus ornithogaster, a filamentous yeast (formerly megabacteriosis); in ventriculus-proventriculus, intestine; kaolin disruption, ulceration, inflammation Dr.'s Southard, Karim, Brayton - tm mice - Leukemia, lymphomas, circulating blasts, marrow and spleen involvement, solid tumors Dr. Bunte - mouse - Demodex muris Dr. Pierce - Cat - Tularemia in pet cat from MD Dr.'s Southard, Brayton - tm mice - Skin, sarcomas Dr.'s Pisharath, Brayton - Zebrafish - Gut - Pseudocapillaria tomentosa Dr.'s Kelley, Montali - Fish, Grunt -- Ectopic Thyroid, heart, gills Dr. Shaw -- Dog, Rhodesian ridgeback -- effusion cytology, lung, liver, marrow -- malignant histiocytosis / histiocytic sarcoma Dr. Montali - Dog, Yorkshire terrier - melanoma August 21, 2007 Dr.'s Manasse, Brayton - marmoset - Zygomycosis, mycotic gastritis, enteritis Dr.'s Manasse, Brayton - marmoset - Amyloidosis, spleen, liver, kidneys, adrenal, intestine, stomach, ovary Dr. Simons - mouse - model of Barret's esophagus Dr. Simons - Tg mouse - Medulloblastoma Dr.'s Pate, Southard - Tg mouse - Rhabdomyosarcoma Dr.'s Mangus, Brayton - ICR mouse - ~ 5mo generalized lymphoma Dr.'s Brice, Brayton - ICR mouse - ~ 5mo Astrocytoma Dr.'s Southard, Brayton - B6,129 ++ mouse - Pituitary adenoma Dr. Pierce - Rooster - Knemicocoptes mutans, hyperkeratosis + acariasis Dr. Pierce - Cat - Pneumonia, abscesses, pyothorax, 3+ Moraxella sp isolated Dr. Pierce - mini foal - Pneumonia, abscesses, Rhodococcus equi isolated Dr. Montali - Chicken - Fowl pox, Bollinger bodies Dr. Montali - Hamster - Flank gland melanocytoma July Slide conference canceled due to June 26, 2007 Dr.'s Southard, Brayton - mouse - enteritis, ileitis, villus shortening, fusion, syncytia, MHV NEG colony Dr. Pierce - dog - Chemodectoma, heart base tumor in Eng Bull dog Dr. Murtazina - mice - induced IBD Inflammatory/proliferative bowel disease) B6 model Dr.'s Kelly, Trembley, Brayton - Xenopus - mycobacteriosis; spleen, liver, kidney, lung necrosis with many Gram POS, AFB Dr.'s Almeida, Convers - mice - M ulcerans arthritis, pododermatitis Dr. Montali - Ferret - necrotizing-pyogranulomatous mesenteric lymphadenititis, r/o FIP-like ferret coronavirus Dr.'s Kelly, Montali, Brayton - mouse -- HAC (hyperkeratosis associated coryneform) bacteria in skin, ear canals of immunodeficient, haired mice Dr. Montali - cat - gastritis, with abundant helical bacteria in mucosa May 15, 2007 Dr.'s Southard, Brayton - mouse - brain abscesses + otitis Dr.'s Southard, Brayton - mouse - oxyuriasis; Aspiculuris with larvae in distal colon/rectum mucosa, gravid females in proximal colon; flagellate protozoa Dr.'s Kelly, Trembley, Brayton - Xenopus - mycobacteriosis; spleen, liver, kidney, lung necrosis with many AFB; intravascular AFB Dr. Southard - poison dart frog -- renal cysts + nephritis Dr. Southard - finch - encephalitis, perivascular (r/o viral) Dr. Brayton - rat - glioblastoma multiforme v histiocytic sarcoma Dr. Montali - hamster - flank glandsApril 17, 2007 Dr.'s Southard, Brayton - mouse - Left atrial/auricular thrombus, LV dilatation (cardiomyopathy) Dr.'s Southard, Brayton - mouse - periarteritis, polyarteritis, heart, mesentery, pancreas Dr. Klinkenberg -- Guinea pig -- Wild type and mutant Mycobacterium tuberculosis Dr. Klinkenberg -- Skh mice -- Mycobacterium tuberculosis in subcutaneous hollow fiber Dr.'s Southard, Brayton - Skh hairless mouse - haired skin, intestinal amyloidosis, mucometra Dr. Simons - tg mice - rhabdomyosarcoma Dr. Simons - mice - naphthalene toxicity Dr. Montali - Cat - Post vaccinal Sarcoma Dr. Montali - Budgerigar - Cutaneus xanthoma March Conference canceled due to Phenotyping Symposium March 20 February 20, 2007 Dr.'s Montali, Brayton, Cooper -Hamster - epitheliotropic lymphoma, Demodex aurati, D criceti Dr.'s Montali & Lorenzo -Anaconda - Entamoeba invadens Dr.s Mankowski & Schultz - Dog - bronchiolitis obliterans, obstructive pneumonia Dr. Karim - Mice - colon crypt dysplasia Dr. Simons - Mouse (nu/nu) - Glomerulonpehritis vs amyloidosis, lymphoplasmacytic interstitial inflammation; adrenal subcapsular cell proliferation; adrenal ceroid lipofuscin deposition Dr. Brayton - Mice (Tm) - Vertebral osteopenia, fracture callus; nasal turbinate fibrous osteodystrophy Dr. Brayton - Mouse (129 background) - cervical spine, brain stem, neoplasm, meningioma Dr. Brayton - Mouse (129 background) - coronary arteritis, periarteritis Dr. Brayton - Mouse (BALB/c) - RVFW epicardial mineralization (dystrophic cardiac calcinosis) Dr. Brayton - Mouse (IL10 tm) - Right auricular/atrial thrombus January 2007Dr. Montali ferrret CDV morbillivirus, hardpad-like lesion Dr. Pisharath Tg zebrafish pancreatic neoplasia Dr. Convers Guinea pig tuberculosis Dr. Simons mice genetically-induced proliferative skin lesions Dr. Simons mice lung adenoma Dr. Southard mouse histiocytic inflammation Dr. Southard rat brain tumor GBM Dr. Brayton dog meningioma Dr. Brayton mouse medulloblastoma November, December 2006 Dr. Southard Mice Vestibular syndrome and brainstem lesions Dr. Montali Xenopus Renal intranuclear inclusion bodies Dr. Montali Rabbit endometrial carcinoma Dr. Brayton Mice spontaneous brain lesions, tauopathy, mineralization Dr. Brayton Mice otitis media -- Bordetella avium isolated Dr. Simons Mice genetically-induced proliferative skin lesions Dr. Karim Rat mammary tumors FNA cytology Dr. Southard Mouse intracranial mammary tissue in compatible with hamartoma |
