Mouse Pathobiology & Phenotyping
PRELIMINARY PROGRAM for a 5day course on mouse biology, pathology, genetics, practical and multidisciplinary phenotyping for translational research.
TARGET AUDIENCE: Graduate students, scientists, veterinarians, pathologists who use or expect to use mice in translational research.
AIMS: To provide information, practical tools and skills essential to the optimal use of mice in translational research.
SYLLABUS: The MOUSE PATHOBIOLOGY & PHENOTYPING MANUAL is the core syllabus material, it can be downloaded (free) by section from this site. Softbound copies can be purchased ($50). It is updated at least annually. Additional course materials are provided at the course.
JHU Graduate Students register for Phenotyping for Functional Genetics, ME:680.712
DVM/VMD RACE application will be submitted.
Day 1 | INTRODUCTION |
9-10am | Brayton - Introduction to phenotyping, fundamental mouse genetics and biology, mouse and gene nomenclature |
1015-1115 | Brayton - Famous mice & Phenotypes |
1130-1230 | Watson - Environmental influences on phenotypes 1 What is in your mouse environment? |
1230-130 | LUNCH |
130-230 | Watson - Environmental influences on phenotypes 2 What ELSE can impact your research and phenotypes ?Your Surveillance Program ... |
245-345 | Brayton - MORE common spontaneous phenotypes that can impact your research |
4-530 pm | Brayton - Infections & infectious phenotypes that can impact your research |
DAY 2 | GEM & Multidisciplinary Phenotyping |
9-10 | Reeves – Making Mice - traditional and new transgenic technologies |
1015-1115 | Jun/Chakravarti - Ophthalmic Phenotyping |
1130-1230 | May - Auditory/acoustic phenotyping |
1230-130 | Pletnikov – Emotional / cognitive phenotyping |
130-230 | Aja/Ronnet - Metabolic Phenotypes *Phenotyping |
245-345 | Mitzner – Pulmonary/respiratory Phenotypes & phenotyping |
4-5 | Gabrielson - IMAGING for Phenotyping |
Gabrielson - Cardiovascular phenotyping In vivo functional correlations to pathology | |
5-7pm | RECEPTION & POSTER SESSION |
Day 3 | Practical Phenotyping 1 |
9-10 | Watson - Clinical / Physical Exam - Modified SHIRPA |
1015-1115 | Brayton - Clinical Pathology - oversimplified |
1130-1230 | Brayton & al - Online & other Resources |
1230-130 | LUNCH |
130-3pm | Watson / Forbes & al LAB 1: Clinical Examination |
315-5pm | Forbes / Brayton & al LAB 2: Clinical Pathology and Specimen collection |
Day 4 | Practical Phenotyping 2 |
9-10 | Brayton - Anatomic Pathology Phenotyping - Necropsy |
1015-1115 | Brayton - Anatomic Pathology Phenotyping - Trimming |
1130-1230 | Brayton - Microscopic Anatomy & Pathology by Virtual Microscopy |
1230-130 | LUNCH |
130-4pm | Forbes / Brayton / Wilcox al. LAB 3: Anatomic Pathology - Necropsy |
4-6pm | Slide Conference - with refreshments |
Day 5 | Practical Phenotyping 3 & QUIZ |
9-1030 | Brayton (or TBA) - Evaluation of Embryos & Pups |
1045-12 | Forbes / Brayton / Wilcox al. LAB 3: Anatomic Pathology - Trimming |
12-1 | LUNCH |
1-230 | QUIZ |
245-5pm | Special Pathology Sessions TBD Immunohistochemistry Quantitative Pathology - Image Analysis Pathology and multidisciplinary databases - ontologies & archiving |
Spontaneous Phenotypes and Conditions in Common Mouse Strains & Stocks | |
Infectious Agents and Phenotypes in Mice | |
Mouse Pathology Glossary: Non Neoplastic; Neoplastic | |
Anatomic Pathology - Necropsy & Trimming Protocol | |
Section 5 | (Relatively) Non Invasive Phenotyping |
Section 6 | Clinical Pathology Resources |
Section 7 | Metabolic Phenotyping resources |
Section 8 | Pregnancy, embryo, pup evaluation |
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| The 2009 phenotyping workshop in Taiwan | |
For additional Course information or to to order a complete manual, or to provide feedback or suggestions - contact Dr. Brayton. | |
