Phenotyping Course Schedule 07

Lecture 3, January 16, 2008

Cory Brayton, DVM, Diplomate ACLAM, ACVP
Director, Phenotyping Core
Associate Professor, Molecular and Comparative Pathobiology

Common spontaneous and infectious phenotypes that can impact research

• Phenotypes to expect with different genetic backgrounds
• Genetic backgrounds that can help or hurt a project
• Phenotypes to expect with some common infections
• Microbial agents that can help or hurt a project

PDF of Spontaneous Disease powerpoint presentation
(26 pages Jan 2008 update)

PDF of Infectious Disease powerpoint presentation
(26 pages Jan 2008 update)

SYLLABUS MATERIAL (relevant to the 1st six lecture and laboratory sessions) :

Outline (PDF) of Spontaneous Diseases in Commonly Used Background Strains and Stocks
(75 pages - Jan 7, 2008 update) 

Outline (PDF) of Infectious Agents and Diseases in Mice
(37 pages - Jan 7, 2008 update) 

A Glossary of Mouse Pathology
(40 pages - Jan 7, 2008 update) 

Poster handout 1 (PDF): Microbe related phenotypes
Poster handout 2 (PDF): Background strain phenotypes   

GO TO JHU RAR Health Surveillance Information
   

Internet Resources

Charles River (Crl) -- Find your mice & their Health Reports

Harlan (Hsd, Ola) -- Find your mice & their Health Reports

JAX (J) -- Find your mice & their Health Reports

NCI Frederick (N, Cr) -- Find your mice & their Health Reports

Taconic (Tac) -- Find your mice & their Health Reports

MU RADIL DORA University of Missouri Research Animal Diagnostic Laboratory
Diseases of Research Animals, Mouse Diseases Site

Additional References

Barthold, S. W. (2002). "Muromics": genomics from the perspective of the laboratory mouse." Comp Med 52(3): 206-23.

Brayton, C., M. Justice, Montgomery, C. (2001). "Evaluating mutant mice: anatomic pathology." Vet Pathol 38(1): 1-19.

Barthold, S. W. (2004). "Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes." Genetica 122(1): 75-88.

Brayton C.  Spontaneous diseases in commonly used inbred mouse strains.  2006. In Fox.  J.G. & al. Ed’s.  In THE MOUSE IN BIOMEDICAL RESEARCH  2nd Ed.  ACLAM series.  Elsevier.

Hedrich H. Ed.  2004. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES:  THE LABORATORY MOUSE. Elsevier. 

Percy, D. H. and S. W. Barthold 3rd ed. (2007). Pathology of Laboratory Rodents and Rabbits. Wiley Liss.

Suckow M, Danneman P, Brayton C.  2001. THE LABORATORY MOUSE. CRC Press, Boca Raton, FL, . (Taylor & Francis, UK).

Sundberg JP, Boggess D, Ed’s.  2002. Systematic Approach to Evaluation of Mouse Mutations.  CRC Press, Boca Raton, FL. (Taylor & Francis, UK)