Phenotyping Course Schedule 07

Lecture 1, January 10, 2007

Cory Brayton, DVM, Diplomate ACLAM, ACVP
Director, Phenotyping Core
Associate Professor, Molecular and Comparative Pathobiology

Course format; Introduction to:

• phenotyping,
• mice and
• mouse/gene nomenclature and resources

PDF Jan 10th Introduction to Phenotyping Part 1 (2.3MB) 
PDF Jan 10th Introduction to Phenotyping Part 2 (5.5MB) 

Poster handout 1 (PDF): Microbe related phenotypes
Poster handout 2 (PDF): Background strain phenotypes

Outline (PDF) of Spontaneous Diseases in Commonly Used Background Strains and Stocks
(note before you print, this is 75 pages long) 

INTERNET RESOURCES YOU SHOULD USE

Mouse/Gene Nomenclature

Search MGI for genes, markers, etc
(including current names, history, homologies, etc)

FIND YOUR MICE at:

Charles River (Crl)

Harlan (Hsd, Ola)

JAX (J)

NCI Frederick (N, Cr)

Taconic (Tac)

FIND GEM MICE at:

Deltagen and Lexicon Knockout Mice and Phenotypic Data

Jax IMSR (Induced Mutant Strain Resource)

MMRRC Mutant Mouse Regional Resource Centers

    
MORE useful internet resources

Edinburgh Mouse Atlas: Digital Atlas of Mouse Development

EUMORPHIA
EMPRESS (European Mouse Phenotyping Resource of Standardised Screens)
EUrophenome Mouse Phenotyping Resource
EUMODIC (European Mouse Disease Clinic) Phenotyping Initiative

Jax - The Jackson Laboratory - Community Resources 
JAX ES Cell lines & strains of origin
JAX Festings information on inbred strains
JAX Lee Silver's MOUSE GENETICS on line
JAX Mouse Phenome database (prioritized strains, protocols, data, more)
JAX Willys Silver's (1979) COAT COLORS OF MICE  

NCI MMHCC (Mouse Models of Human Cancer Consortium) Site
(Model information with links to Consensus papers, protocols, etc)

NIH KOMP (Knockout Mouse Project)

NorCOMM (North American Conditional Mutant Mouse Project)

Pathbase: European mutant mouse pathology database

Additional References

Barthold, S. W. (2002). "Muromics": genomics from the perspective of the laboratory mouse." Comp Med 52(3): 206-23.

Barthold, S. W. (2004). "Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes." Genetica 122(1): 75-88.

Brayton, C., M. Justice, Montgomery, C. (2001). "Evaluating mutant mice: anatomic pathology." Vet Pathol 38(1): 1-19.

Brayton C.  Spontaneous diseases in commonly used inbred mouse strains.  2006. In Fox.  J.G. & al. Ed’s.  In THE MOUSE IN BIOMEDICAL RESEARCH  2nd Ed.  ACLAM series.  Elsevier.

Hedrich H. Ed.  2004. THE HANDBOOK OF EXPERIMENTAL ANIMALS SERIES:  THE LABORATORY MOUSE. Elsevier. 

Hrabé de Angelis, M. & al. Eds. 2006. STANDARDS OF MOUSE MODEL PHENOTYPING. Wiley-VCH, Weinheim, ISBN 3-527-31031-2

Kaufman MH.  1992.  ATLAS OF MOUSE DEVELOPMENT.  Academic Press

Maronpot, R. & al., Eds. (1999). PATHOLOGY OF THE MOUSE: REFERENCE AND ATLAS. Cache River Press. Vienna, IL,

Papaioannou VE,  Behringer RR.  2004. MOUSE PHENOTYPES: A HANDBOOK OF MUTATION ANALYSIS.  Cold Spring Harbor Laboratory Press; Cold Spring Harbor, NY  (review in Nature)

Smith, R. S. (2001). Systemic Evaluation of the Mouse Eye, Anatomy, Pathology, and Biomethods. Boca Raton, FL., CRC Press, (Taylor & Francis, UK).

Suckow M, Danneman P, Brayton C.  2001. THE LABORATORY MOUSE. CRC Press, Boca Raton, FL, . (Taylor & Francis, UK).

Sundberg JP, Boggess D, Ed’s.  2002. Systematic Approach to Evaluation of Mouse Mutations.  CRC Press, Boca Raton, FL. (Taylor & Francis, UK)

Sundberg, J. and T. Ichiki (2005). Genetically Engineered Mice Handbook. CRC Press;  Boca Raton, FL (Taylor & Francis UK).

Ward JM, Maronpot RR, Sundberg JP.  2000.   PATHOLOGY OF GENETICALLY ENGINEERED MICE. Ames, IA, Iowa State University Press (Blackwell Publishing)