680.707 Experimental Design and Scientific Writing

8/29/2011

Cory Brayton, DVM, DipACLAM, Dip ACVP, Associate Professor, MCP
The ARRIVE guidelines: Animal research: reporting in vivo experiments – international guidelines and recommendations to improve translatability of translational science in animal models
Suggested References/Resources

1. ILAR-NRC, Guidance for the Description of Animal Research in Scientific Publications2011, Washington, D.C.: The National Academies Press.  National Academy of Sciences. http://dels.nas.edu/Report/Guidance-Description-Animal/13241.
2. Kilkenny, C., W. J. Browne, et al. (2010). Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8(6): e1000412 http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1000412
3. Kilkenny, C., N. Parsons, et al. (2009). Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4(11): e7824. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007824
4. Workman, P., E. O. Aboagye, et al. (2010). Guidelines for the welfare and use of animals in cancer research. Br J Cancer 102(11): 1555-1577. http://www.nature.com/bjc/journal/v102/n11/full/6605642a.html

9/12/2011

Chris Zink, DVM, PhD, Dip ACVP, Professor and Director, MCP 
Over 10 years from grant to publication – What took so long and what could have been done differently

1. 1. The Grant – Establishing a New Collaboration
2. The Grant Review
3. The Studies
4. The Writing Process

Weed M, Adams RJ, Hienz RD, Meulendyke KA, Linde ME, Clements JE, Mankowski JL, Zink MC. SIV/Macaque Model of HIV Infection in Cocaine Users: Minimal Effects of Cocaine on Behavior, Virus Replication, and CNS Inflammation

9/19/2011

Pat Tarwater, PhD, Statistics
Study Designs and Analyses in Basic and Clinical Research

Objective: To present and motivate the association between epidemiologic concepts and statistical tools for the purpose of guiding quality research questions.

 9/20/2011

Pat Tarwater, PhD, Statistics 
Data Analysis in Basic and Clinical Research

Objective: To present and motivate the association between epidemiologic concepts and statistical tools for the purpose of guiding quality research questions

9/26/2011

David Graham, PhD; Assistant Professor, MCP

Abstract: This class will cover all of the aspects of designing a project using a real example of a publication from the instructor. The goal of this class is to identify the experimental design process from start to finish highlighting what was done versus what "should" have been done. The manuscript will encompass appropriate experimental design, the use of power modeling for statistics and problems that arise based on the interpretation of date - project evolution. This class uses an animal model of hypertropic cardiomyopathy, proteomics, mass spectrometry and biochemistry. Practical considerations like authorship, funding, distribution of labor and managing collaborations will be discussed.

10/10/2011

Bob Adams, DVM, DipACLAM; Associate Professor MCP; Director RAR
1. The Institutional Animal Care and Use Committee

• Purpose and responsibility
• Committee make up and review process
• Protocol review form

2. R25 grant

• RFA
• Building on long success of T32 grant and existing residency training program

Handouts: IACUC review form; R 25 grant RFA; R 25 grant proposal

10/17/11

Janice Clements, PhD, Professor MCP; Vice Dean for Faculty

10/24/2011

Joseph Mankowski, DVM, PhD, DipACVP; Associate Professor, MCP

10/31/2011

Sarah Poynton, PhD, ASsociate Professor, MCP 
The transition from good to excellent writing

11/7/2011

David Huso, DVM, PhD, DipACVP; Associate Professor, MCP

11/14/2011

Kathleen Gabrielson, DVM, PhD, DipACVP; Associate Professor, MCP 
Hypothesis to publication: Why study erbb2 expression in the heart? Implications for therapy for breast cancer and for heart disease therapy

PDF of syllabus with additional detail

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