In This Section      
Print This Page

680.707 Experimental Design and Scientific Writing

SOM Graduate School course ME: 680.707 - Experimental Design and Scientific Writing

Instructors: Dr. Zink, MCP faculty, others.

Description: First Quarter. 2-330pm Mondays. Room to be announced.

Topics include:

  • Experimental design
  • Research protocols and practice
  • Data handling and research integrity
  • Publication: authorship, scientific writing, journal selection, peer�review, manuscript revision
  • Faculty are encouraged to discuss studies that entailed difficult decisions/conundrums.

2011 Lecture Schedule


Cory Brayton, DVM, DipACLAM, Dip ACVP, Associate Professor, MCP
The ARRIVE guidelines: Animal research: reporting in vivo experiments – international guidelines and recommendations to improve translatability of translational science in animal models
Suggested References/Resources

  1. ILAR-NRC, Guidance for the Description of Animal Research in Scientific Publications2011, Washington, D.C.: The National Academies Press.  National Academy of Sciences.
  2. Kilkenny, C., W. J. Browne, et al. (2010). Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8(6): e1000412
  3. Kilkenny, C., N. Parsons, et al. (2009). Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4(11): e7824.
  4. Workman, P., E. O. Aboagye, et al. (2010). Guidelines for the welfare and use of animals in cancer research. Br J Cancer 102(11): 1555-1577.


Chris Zink, DVM, PhD, Dip ACVP, Professor and Director, MCP 
Over 10 years from grant to publication – What took so long and what could have been done differently

  1. 1. The Grant – Establishing a New Collaboration
  2. The Grant Review
  3. The Studies
  4. The Writing Process

Weed M, Adams RJ, Hienz RD, Meulendyke KA, Linde ME, Clements JE, Mankowski JL, Zink MC. SIV/Macaque Model of HIV Infection in Cocaine Users: Minimal Effects of Cocaine on Behavior, Virus Replication, and CNS Inflammation


Pat Tarwater, PhD, Statistics
Study Designs and Analyses in Basic and Clinical Research

Objective: To present and motivate the association between epidemiologic concepts and statistical tools for the purpose of guiding quality research questions.


Pat Tarwater, PhD, Statistics 
Data Analysis in Basic and Clinical Research

Objective: To present and motivate the association between epidemiologic concepts and statistical tools for the purpose of guiding quality research questions


David Graham, PhD; Assistant Professor, MCP

Abstract: This class will cover all of the aspects of designing a project using a real example of a publication from the instructor. The goal of this class is to identify the experimental design process from start to finish highlighting what was done versus what "should" have been done. The manuscript will encompass appropriate experimental design, the use of power modeling for statistics and problems that arise based on the interpretation of date - project evolution. This class uses an animal model of hypertropic cardiomyopathy, proteomics, mass spectrometry and biochemistry. Practical considerations like authorship, funding, distribution of labor and managing collaborations will be discussed.


Bob Adams, DVM, DipACLAM; Associate Professor MCP; Director RAR
1. The Institutional Animal Care and Use Committee

  • Purpose and responsibility
  • Committee make up and review process
  • Protocol review form

2. R25 grant

  • RFA
  • Building on long success of T32 grant and existing residency training program

Handouts: IACUC review form; R 25 grant RFA; R 25 grant proposal


Janice Clements, PhD, Professor MCP; Vice Dean for Faculty


Joseph Mankowski, DVM, PhD, DipACVP; Associate Professor, MCP


Sarah Poynton, PhD, ASsociate Professor, MCP 
The transition from good to excellent writing


David Huso, DVM, PhD, DipACVP; Associate Professor, MCP


Kathleen Gabrielson, DVM, PhD, DipACVP; Associate Professor, MCP 
Hypothesis to publication: Why study erbb2 expression in the heart? Implications for therapy for breast cancer and for heart disease therapy


PDF of syllabus with additional detail