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The Analytical Pharmacology Core offers state-of-the-art and cost-effective analytical chemistry and clinical pharmacology services. It provides instrumentation and facilities to provide expertise in clinical trial and preclinical study design. The focus is:
- critical pharmacological endpoints,
- state-of-the-art, Good Laboratory Practice (GLP)-quality and cost-effective services to quantitate anticancer drugs and metabolites in biological fluids, and
- pharmacokinetic/pharmacodynamic data analysis and interpretation for drug development.
The Core houses four UPLC/HPLC instruments with a UV/fluorescence, a triple stage quadruple mass spectrometer, and a QTrap system with ion trap capabilities for more intricate drug metabolism studies. It analyzes more than 3,200 samples and develops 15 new methods per year. It is a critical component across the translational spectrum, providing services in analytical method development, drug discovery, preclinical studies, and clinical trials. This Core helped launch the Johns Hopkins Early Therapeutics Clinical Trials Network, AIDS Malignancy Consortium, and was a second laboratory for the Adult Brain Tumor Consortium.
Michelle A. Rudek, Pharm.D., Ph.D., Resource Director
Nicole Anders, M.S., Resource Manager