Understanding Mechanisms of Response and Resistance to Androgen-Directed Therapies in Men with Advanced Prostate Cancer Through Interrogation of Tumor Biopsies: A Pilot/Feasibility Study
To test the possibility of obtaining tumor biopsy samples from men with advanced prostate cancer before, during, and after treatment with a variety of androgen-directed therapies,To understand some of the mechanisms of response and resistance to androgen-directed therapies of tumors
Must have recurrent or advance prostate cancer, musst be about to begin treatment with an androgen-directed therapy, be at least 18 years of age, have at least one metastatic lesion that is readily able to be biopsed, willingness to have 3 blood collections and/or up to 3 image-guided tumor biopsies or metastatic tissue
Samples (blood and/or tumor) will be collected before starting androgen-directed therapy, at the time of a response to treatment and at the time of treatment resistence.
12/11/2013 04:02 AM