Understanding Mechanisms of Response and Resistance to Androgen-Directed Therapies in Men with Advanced Prostate Cancer Through Interrogation of Tumor Biopsies
Sibley Memorial Hospital
Johns Hopkins Kimmel Cancer Center in Baltimore
To test the possibility of obtaining tumor biopsy samples from men with advanced prostate cancer before, during, and after treatment with a variety of androgen-directed therapies,To understand some of the mechanisms of response and resistance to androgen-directed therapies of tumors
Must have recurrent or advance prostate cancer, musst be about to begin treatment with an androgen-directed therapy, be at least 18 years of age, have at least one metastatic lesion that is readily able to be biopsed, willingness to have 3 blood collections and/or up to 3 image-guided tumor biopsies or metastatic tissue
Samples (blood and/or tumor) will be collected before starting androgen-directed therapy, at the time of a response to treatment and at the time of treatment resistence.
05/29/2016 05:03 AM