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Title:
Genome Wide Admixture for Multiple Myeloma in Africian Americans. (Africian-American MM GWAS)
Protocol Number:
J1141
Phase:
NULL
Physician:
Carol Huff
Purpose:
Multiple myeloma is a malignancy consisting of a neoplastic clone of plasma cells, the terminally-differentiated B lymphocytes responsible for antibody production. In spite of recent therapeutic advances such as Bortezomib or Thalidomide resulting in some improved survival, especially for younger patients1, the overall five-year survival rate remains under 40% for men and women over all ages. MM has a poor survival rate and remains the second leading cause of death due to a hematologic malignancy. Causes are unknown but African Americans experience over two times the risk of Whites and there is strong evidence to suggest a genetic contribution to risk. The goal of this project is to identify genetic determinants of MM, which will lead to a better informed and more targeted approach to disease prevention and treatment.
Eligibility:
English speaking Self reported African American Age greater than 20 Physician diagnosed multiple myeloma (including smoldering) diagnosed after July 1, 2008.
Treatment:
Collect blood samples from African American men and women with clinically confirmed MM, and newly diagnosed MM patients after July 1 2008. This is an observational study (no intervention).
Population:
Adult
Last Update
09/23/2014 04:03 AM
 

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