Skip Navigation
Print This Page
Share this page: More

Search Results

Phase 1B Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children With Neutropenia
Protocol Number:
Phase I
Patrick Brown
The primary objective of this study is to evaluate the blood levels of posaconazole administered orally at three dosage levels to immunocompromised children aged 3 months to less than 18 years with neutropenia or expected neutropenia.
Subjects enrolled will be immunocompromised children 3 months to less than 18 years of age with neutropenia or expected neutropenia. The study drug will be given following chemotherapy given for a diagnosis of leukemia (newly diagnosed or relapsed), myelodysplastic syndrome, advanced stage non-Hodgkinâ??s lymphoma, high risk neuroblastoma, and patients undergoing autologous or allogeneic HSCT during the pre-engraftment period.
Invasive fungal infections (IFIs) are a leading cause of infectious disease morbidity and mortality in immunocompromised patients. Like adults, the pediatric patient population at risk for developing IFIs is similar. Clinical studies in subjects (â?¥ 13 years of age) using posaconazole oral suspension support its use in the treatment of severely Immunocompromised patients, either for prevention or treatment of IFIs. While the data obtained thus far in pediatric subjects suggests posaconazole has been well tolerated and is therapeutic, there is limited information about this population.
Last Update
11/26/2014 04:10 AM

Read Our Blogs
Cancer Matters: timely topics
Our Cancer: for caregivers


Cancer Dictionary

NCI Dictionary of Cancer Terms, a resource with more than 6,000 terms related to cancer and medicine.

Traveling for care?

blue suitcase

Whether crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Maryland 410-955-5222
U.S. 410-955-5222
International +1-410-614-6424



© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.