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Title:
Psychopharmacology of psilocybin in cancer patients
Protocol Number:
J0647
Phase:
Pilot
Physician:
Roland Griffiths
Purpose:
Johns Hopkins University School of Medicine is seeking volunteers with a diagnosis of cancer who are experiencing anxious or depressed mood to participate in a scientific study of states of consciousness brought about by the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting.
Eligibility:
- high school level of education - 21 to 70 years old - have a cancer diagnosis that is potentially life-threatening and with the disease progressing within 1 year prior to study entry, as judged by the referring physician. - have an ECOG performance status of 0, 1, or 2. - experiencing symptoms of depression or anxiety related to cancer diagnosis - be between cancer therapies or have independently decided to not undergo direct cancer treatments, such as chemotherapy and radiation, for at least an approximately 1 month duration - good liver function - no cancer with known CNS involvement, or other major CNS disease. - no major cardiovascular conditions or epilepsy - no females who are pregnant or nursing - other medical and psychiatric exclusions may apply
Treatment:
Questionnaires and interviews will be used to assess the effects of psilocybin on consciousness, mood, and behavior. Volunteers enrolled in the study will receive careful preparation and 2 outpatient sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences.
Population:
Adult
Last Update
09/22/2014 04:03 AM
 

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