Psychopharmacology of psilocybin in cancer patients
Johns Hopkins University School of Medicine is seeking volunteers with a diagnosis of cancer who are experiencing anxious or depressed mood to participate in a scientific study of states of consciousness brought about by the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting.
- high school level of education - 21 to 70 years old - have a cancer diagnosis that is potentially life-threatening and with the disease progressing within 1 year prior to study entry, as judged by the referring physician. - have an ECOG performance status of 0, 1, or 2. - experiencing symptoms of depression or anxiety related to cancer diagnosis - be between cancer therapies or have independently decided to not undergo direct cancer treatments, such as chemotherapy and radiation, for at least an approximately 1 month duration - good liver function - no cancer with known CNS involvement, or other major CNS disease. - no major cardiovascular conditions or epilepsy - no females who are pregnant or nursing - other medical and psychiatric exclusions may apply
Questionnaires and interviews will be used to assess the effects of psilocybin on consciousness, mood, and behavior. Volunteers enrolled in the study will receive careful preparation and 2 outpatient sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences.
09/30/2014 04:03 AM